By Professor Peter Gunning

Journal articles

Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', Intravital, 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287

Lee ASJ; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture.', Bioarchitecture, 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966

Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489

Gunning P, 2013, 'Welcome to BioArchitecture 2013', BioArchitecture, 3, pp. 1 - 1, http://dx.doi.org/10.4161/bioa.24027

Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 Regulates Protein Partner Interactions and Ubiquitin-Mediated Degradation', Plos One, 7, http://dx.doi.org/10.1371/journal.pone.0049283

Desouza M; Gunning PW; Stehn JR, 2012, 'The actin cytoskeleton as a sensor and mediator of apoptosis.', Bioarchitecture, 2, pp. 75 - 87, http://dx.doi.org/10.4161/bioa.20975

Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan Y-KA; Yeo J-L; Adams M; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, http://dx.doi.org/10.1242/jcs.102798

Gunning P, 2012, 'BioArchitecture : A reflection on 2011 and looking forward to 2012.', Bioarchitecture, 2, pp. 1, http://dx.doi.org/10.4161/bioa.20320

Schevzov G; Coombes J; Hook J; Wang B; Kee A; Lucas C; Szokolai R; Sequeira V; Stehn J; Musgrove E; Hardeman E; Gunning P, 2012, 'Regulation of cell proliferation mediated by the actin filament stabilizing protein, Tropomyosin 5NM1.', MOLECULAR BIOLOGY OF THE CELL, 23, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601219&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gunning P, 2012, 'BioArchitecture: the organization and regulation of biological space.', Bioarchitecture, 2, pp. 200 - 203, http://dx.doi.org/10.4161/bioa.22726

Schevzov G; Curthoys NM; Gunning P; Fath T, 2012, 'Chapter Two – Functional Diversity of Actin Cytoskeleton in Neurons and its Regulation by Tropomyosin', International Review of Cell and Molecular Biology, 298, pp. 33 - 94, http://dx.doi.org/10.1016/B978-0-12-394309-5.00002-X

Angrisano F; Riglar D; Sturm A; Volz J; Delves MJ; Zuccala E; Turnbull L; Dekiwadia C; Olshina MA; Marapana DS; Wong W; Mollard V; Bradin CH; Tonkin CJ; Gunning P; Ralph SA; Whitchurch CB; Sinden RE; Cowman AF; McFadden GI; Baum J, 2012, 'Spatial localisation of actin filaments across developmental stages of the malaria parasite', PLoS ONE, 7, pp. Article number e32188, http://dx.doi.org/10.1371/journal.pone.0032188

Guven K; Gunning P; Fath T, 2011, 'TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses.', Bioarchitecture, 1, pp. 284 - 289, http://dx.doi.org/10.4161/bioa.1.6.19336

Lees JG; Bach CTT; Bradbury P; Paul A; Gunning PW; O'Neill GM, 2011, 'The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility', Oncogene, 30, pp. 1241 - 1251, http://dx.doi.org/10.1038/onc.2010.516

Gunning P, 2011, 'Welcome to the first issue of Bioarchitecture', Bioarchitecture, 1, pp. 1, http://dx.doi.org/10.4161/bioa.1.1.15419

Tojkander S; Gateva G; Schevzov G; Hotulainen P; Naumanen P; Martin C; Gunning PW; Lappalainen P, 2011, 'A Molecular Pathway for Myosin II Recruitment to Stress Fibers', Current Biology, 21, pp. 539 - 550, http://dx.doi.org/10.1016/j.cub.2011.03.007

Hook J; Lemckert F; Schevzov G; Fath T; Gunning P, 2011, 'Functional identity of the gamma tropomyosin gene: Implications for embryonic development, reproduction and cell viability.', Bioarchitecture, 1, pp. 49 - 59, http://dx.doi.org/10.4161/bioa.1.1.15172

Nguyen MA; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.', Brain, 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274

Creed S; Desouza M; Bamburg J; Gunning P; Stehn J, 2011, 'Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments', Experimental Cell Research, 317, pp. 249 - 261, http://dx.doi.org/10.1016/j.yexcr.2010.10.019

Schevzov G; Whittaker SP; Fath T; Lin JJ; Gunning PW, 2011, 'Tropomyosin isoforms and reagents.', Bioarchitecture, 1, pp. 135 - 164, http://dx.doi.org/10.4161/bioa.1.4.17897

Gallant C; Appel S; Graceffa P; Leavis P; Lin JJ-C; Gunning P; Schevzov G; Chaponnier C; DeGnore J; Lehman W; Morgan K, 2011, 'Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells', American Journal of Physiology - Cell Physiology, 300, pp. 1356 - 1365, http://dx.doi.org/10.1152/ajpcell.00450.2010

Shum MSY; Pasquier E; Po'uha ST; O'Neill GM; Chaponnier C; Gunning PW; Kavallaris M, 2011, 'γ-Actin regulates cell migration and modulates the ROCK signaling pathway', FASEB JOURNAL, 25, pp. 4423 - 4433, http://dx.doi.org/10.1096/fj.11-185447

Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Taylor KM; Tay ESE; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', Journal of Biological Chemistry, 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660

Hu M; Kramer B; Howden B; Zhang G; Wang YM; McCowage G; Alexander I; Gunning P; Alexander SI, 2010, 'ALLOGRAFT TOLERANCE IN MICE WITH MGMT CHIMERIC BONE MARROW ENGRAFTMENT', Transplantation Journal, 90, pp. 233 - 233, http://dx.doi.org/10.1097/00007890-201007272-00441

Martin C; Schevzov G; Gunning P, 2010, 'Alternatively spliced N-terminal exons in tropomyosin isoforms do not act as autonomous targeting signals', Journal of Structural Biology, 170, pp. 286 - 293

Irimia M; Gunning P; Maeso I; Garcia-Fernandez J; Roy SW, 2010, 'Internal and external paralogy in the evolution of Tropomyosin genes in metazoans', Molecular Biology and Evolution, 27, pp. 1504 - 1517, http://dx.doi.org/10.1093/molbev/msq018

Fath T; Agnes Chan Y-K; Vrhovski B; Clarke H; Curthoys N; Hook J; Lemckert F; Schevzov G; Tam P; Watson CM; Khoo P-L; Gunning P, 2010, 'New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2', European Journal of Cell Biology, 89, pp. 489 - 498, http://dx.doi.org/10.1016/j.ejcb.2009.11.028

Bach CTT; Schevzov G; Bryce NS; Gunning PW; O'Neill GM, 2010, 'Tropomyosin isoform modulation of focal adhesion structure and cell migration', Cell Adhesion & Migration, 4, pp. 226 - 234, http://dx.doi.org/10.4161/cam.4.2.10888

Bach CTT; Creed S; Zhong J; Mahmassani M; Schevzov G; Stehn J; Cowell LN; Naumanen P; Lappalainen P; Gunning PW; O'Neill GM, 2009, 'Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction', Molecular and Cellular Biology, 29, pp. 1506 - 1514, http://dx.doi.org/10.1128/MCB.00857-08

Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, 66, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400

Vlahovich N; Kee AJ; Van der Poel C; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, 20, pp. 400 - 409, http://www.molbiolcell.org/cgi/content/abstract/E08-06-0616v1

Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, 30, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x

Schevzov G; Fath T; Gunning P, 2009, 'Intracellular structural compartments, disease and tropomyosins', Current Topics in Pharmacology, 13, pp. 1 - 15

Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28

Bonello T; Stehn J; Gunning P, 2009, 'New approaches to targeting the actin cytoskeleton for chemotherapy.', Future Medicinal Chemistry, pp. 1311 - 1331

Fath T; Ke YD; Gunning P; Götz J; Ittner LM, 2009, 'Primary support cultures of hippocampal and substantia nigra neurons', Nature Protocols, 4, pp. 78 - 85, http://dx.doi.org/10.1038/nprot.2008.199

Gunning P, 2008, 'Emerging issues for tropomyosin structure, regulation, function and pathology', Advances in Experimental Medicine and Biology, 644, pp. 293 - 298, http://dx.doi.org/10.1007/978-0-387-85766-4_22

Gunning P, 2008, 'Introduction and historical perspective', Advances in Experimental Medicine and Biology, 644, pp. 1 - 5, http://dx.doi.org/10.1007/978-0-387-85766-4_1

Martin C; Gunning P, 2008, 'Isoform sorting of tropomyosins', Advances in Experimental Medicine and Biology, 644, pp. 187 - 200, http://dx.doi.org/10.1007/978-0-387-85766-4_15

Creed SJ; Bryce N; Naumanen P; Weinberger R; Lappalainen P; Stehn J; Gunning P, 2008, 'Tropomyosin isoforms define distinct microfilament populations with different drug susceptibility', European Journal of Cell Biology, 87, pp. 709 - 720, http://dx.doi.org/10.1016/j.ejcb.2008.03.004

O'Neill GM; Stehn J; Gunning PW, 2008, 'Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton', Seminars in Cancer Biology, 18, pp. 35 - 44, http://dx.doi.org/10.1016/j.semcancer.2007.08.004

Vlahovich N; Schevzov G; Nair-Shaliker V; Ilkovski B; Artap ST; Joya JE; Kee AJ; North KN; Gunning PW; Hardeman EC, 2008, 'Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle', Cell Motility and the Cytoskeleton, 65, pp. 73 - 85, http://dx.doi.org/10.1002/cm.20245

Gunning P; O'Neill G; Hardeman E, 2008, 'Tropomyosin-based regulation of the actin cytoskeleton in time and space', Physiological Reviews, 88, pp. 1 - 35, http://dx.doi.org/10.1152/physrev.00001.2007

Thoms J; Loch H; Bamburg J; Gunning P; Weinberger R, 2008, 'A tropomyosin 1 induced defect in cytokinesis can be rescued by elevated expression of cofilin', Cell Motility and the Cytoskeleton, 65, pp. 979 - 990

MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380

Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJ-C; Hardeman EC; Wieczorek DF; O'Neill GM; Gunning PW, 2008, 'Divergent Regulation of the Sarcomere and the Cytoskeleton', Journal of Biological Chemistry, 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.m704392200

Ke YD; Ittner LM; Gunning P; Gotz J; Fath T, 2008, 'P1‐142: A new neurotrophic support culture technique for primary neurons', Alzheimer's & Dementia, 4, http://dx.doi.org/10.1016/j.jalz.2008.05.729

Ittner LM; Ke YD; Fath T; Schonrock N; Gunning P; Gotz J, 2008, 'P2‐129: Parkinsonism and memory impairment in tau transgenic mice with axonal transport defects', Alzheimer's & Dementia, 4, http://dx.doi.org/10.1016/j.jalz.2008.05.1202

Ittner LM; Fath T; Ke YD; Bi M; van Eersel J; Li KM; Gunning P; Gotz J, 2008, 'Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia', Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 15997 - 16002, http://dx.doi.org/10.1073/pnas.0808084105

Chang AC; Hook J; Lemckert FA; McDonald M; Nguyen MA; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219

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