By Professor Peter Gunning

Conference Abstracts

Ghosh A; Janco M; Bocking T; Gunning PW; Lehman W; Rynkiewicz MJ, 2019, 'Structure of the Tpm3.1 N-Terminus: A New Target for Anti-Cancer Treatment', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 116, pp. 253A - 254A, presented at 63rd Annual Meeting of the Biophysical-Society, MD, Baltimore, 02 March 2019 - 06 March 2019, http://dx.doi.org/10.1016/j.bpj.2018.11.1382

Wang Y; Swain A; Stear JH; Bryce NS; Dugina VB; Alieva IB; Cripe TP; Stehn JR; Hardeman EC; Gunning PW, 2017, 'Synergy between anti-tropomyosin and anti-microtubule drugs reveals an interaction between actin and microtubule networks.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 28, presented at Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO), PA, Philadelphia, 02 December 2017 - 06 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426664301293&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Meiring JC; Bryce NS; Stear JH; Hardeman EC; Gunning PW, 2017, 'The tropomyosin isoform composition of cellular actin filaments is not a simple function of relative isoform abundance.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 28, presented at Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO), PA, Philadelphia, 02 December 2017 - 06 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426664301286&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Rynkiewicz M; Stehn J; Gunning P; Lehman W, 2017, 'Structure of the Anti-Cancer Compound TR100 Target-Sites on Tpm3.1 Tropomyosin', in Biophysical Journal, Elsevier, Vol. 112, pp. 560a, http://dx.doi.org/10.1016/j.bpj.2016.11.3019

Stehn JR; Stevenson A; Spoerri L; Daignault SM; Gabrielli B; Eiffe E; Gunning PW; Haass N, 2016, 'Developing a new melanoma drug', in AUSTRALASIAN JOURNAL OF DERMATOLOGY, WILEY-BLACKWELL, Vol. 57, pp. 11 - 12, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000374686200029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Stehn J; Currier M; Chen D; Eiffe E; Heaton A; Hook J; Gunning P; Cripe T, 2015, 'First-in-class cytoskeletal targeting drug, Anisina, enhances effectiveness of microtubule inhibitors in a preclinical model of neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, FL, Fort Lauderdale, Vol. 76, presented at AACR Special Conference on Advances in Pediatric Cancer Research - From Mechanisms and Models to Treatment and Survivorship, FL, Fort Lauderdale, 09 November 2015 - 12 November 2015, http://dx.doi.org/10.1158/1538-7445.PEDCA15-B27

Fath T; Brettle M; Janitz M; Gunning P, 2015, 'Manipulation of the actin cytoskeleton promotes neurite outgrowth on inhibitory substrates', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, Vol. 134, pp. 311 - 311, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300790&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin Tropomyosin Assembly Intermediates', in BIOPHYSICAL JOURNAL., CELL PRESS, Vol. 108, pp. 298A - 298A, presented at AACR Special Conference on Advances in Pediatric Cancer Research

Kee AJ; Tran L; Yang L; Genel F; Weigert R; Gunning P; Hardeman E, 2013, 'Identification of a novel Golgi-associated actin filament population that is important for maintaining Golgi morphology', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Stehn JR; Haass NK; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Han MH; Hill TA; McCluskey A; Palmer S; Hardeman EC; Weninger W; Cripe TR; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1827

Segueira VB; Stehn JR; Haass N; Bonello T; Guven K; Desouza M; Schevzov G; Kottyan G; McCluskey A; Bischof L; Palmer S; Hardeman EC; Allanson M; Reeve V; Weninger W; Cripe TP; Gunning P, 2012, 'Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-5230

Maytum R; Gunning P; Lin J; Copeland O; Bayliss C; Marston S, 2011, 'Analysis of Tropomyosin (Tm) Isoforms in Heart Muscle by LC/MS and Western Blotting Demonstrates Previously Uncharacterised High-Level Expression of gamma Tm', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 100, pp. 371 - 371, presented at 55th Annual Meeting of the Biophysical-Society, MD, Baltimore, 05 March 2011 - 09 March 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000306288603140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gunning P; Weinberger R; Schevzov G; Percival J; Hannan A; Dufour C; Qin H; Ferguson V; Jeffrey P, 1996, 'Spatial segregation of microfilament isoforms in neurons and cycling fibroblasts.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 7, pp. 1972 - 1972, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996WB01801969&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Gunning P; Stehn J; McCluskey A; Butler T; Dixon I, 2007, Compounds for treating Cancer, Australia, Patent No. Australian Provisional Patent Application No 2007906570

Gunning P; Stehn J; Schevzov G, 2005, Identification of compounds for the treatment of proliferative disorders, Australia, Patent No. Australian Provisional Patent Application No 2004906888

Preprints

Mann Z; Verma S; Chen O; Dunbabin P; Ju RJ; Hu C; Lim Kam Sian TCC; Hardeman EC; Gunning PW; Daly RJ; Duszyc K; Poole K; Yap AS, 2026, The way less obvious: PIEZO1 supports apoptotic cell extrusion by optimizing tissue mechanical tension for homeostasis, http://dx.doi.org/10.64898/2026.06.01.729446

Heydecker M; Chen D; Masedunskas A; Mikolaj M; Narayan K; Chen J; Vishwasrao H; Meckel T; Hardeman E; Gunning P; Weigert R, 2026, Intravital single-molecule imaging reveals cytoskeletal turnover as a driver of membrane remodeling in live animals., http://dx.doi.org/10.64898/2026.02.25.708035

Heydecker M; Shitara A; Chen D; Tran D; Masedunskas A; Tora M; Ebrahim S; Appaduray MA; Galeano Niño JL; Bhardwaj A; Narayan K; Hardeman EC; Gunning PW; Weigert R, 2023, Spatial and Temporal Coordination of Force-generating Actin-based Modules Drives Membrane Remodeling In Vivo., http://dx.doi.org/10.1101/2023.12.04.569944

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2019, Tropomyosin Tpm3.1 is Required to Maintain the Structure and Function of the Axon Initial Segment, http://dx.doi.org/10.2139/ssrn.3448139

Latham SL; O’Donnell YE; Girgis-Cook O; Clearwater MS; Bryce NS; Mok ET; Lynn SA; Ni J; Alfred S; Leong H; Quek L-E; Murphy KJ; Pantarelli C; Dragutinovic I; Naeini MM; Thiel C; Cadell A; Phimmachanh M; Sharma R; Millar E; Han JZ; Hastings JF; Köhler M; Brummer T; Young A; O’Toole S; Oakes SR; Hardeman E; Lock J; Kolch W; Taft MH; Nobis M; Goldstein L; Timpson P; Parker BL; Holst J; Gunning PW; Cox TR; Morris JC; Croucher DR, A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade, http://dx.doi.org/10.1101/2025.04.16.649243

Gan WJ; Giri R; Begun J; Abud HE; Hardeman EC; Gunning PW; Yap AS; Noordstra I, A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension, http://dx.doi.org/10.1101/2024.03.06.583801

Rae J; Ferguson C; Ariotti N; Webb RI; Cheng H-H; Mead JL; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Hardeman EC; Gunning PW; Gambin Y; Hall T; Parton RG, APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy, http://dx.doi.org/10.1101/2020.10.06.328831

Zhao X; Alibhai D; Walsh T; Tarassova N; Englert M; Birol S; Li Y; Williams C; Neal C; Burkard P; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Nieswandt B; Hers I; Ghevaert C; Poole A, Highly efficient platelet generation in lung vasculature reproduced by microfluidics, http://dx.doi.org/10.21203/rs.3.rs-2306404/v1

Genoud S; Chaichim C; Porto RR; Tomanic T; Stefen H; Paric E; Sarkar S; Yoo D; Gao W; Hardeman EC; Gunning PW; Karl T; Power J; Fath T, Knock-out of Tpm4.2/actin filaments alters neuronal signaling, neurite outgrowth and behavioral phenotypes in mice, http://dx.doi.org/10.1101/2025.04.10.648285

Zhao X; Alibhai D; Walsh TG; Tarassova N; Birol SZ; Williams CM; Neil CR; Aitken EW; Waller AK; Ballester-Beltran J; Gunning PW; Hardeman EC; Agbani EO; Hers I; Ghevaert C; Poole AW, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.1101/2021.11.01.466743

Zhao X; Alibhai D; Walsh T; Tarassova N; Birol S; Williams C; Neil C; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Hers I; Ghevaert C; Poole A, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.21203/rs.3.rs-690639/v1

Mann Z; Lim F; Verma S; Nanavati BN; Davies JM; Begun J; Hardeman EC; Gunning PW; Subramanyam D; Yap AS; Duszyc K, Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia, http://dx.doi.org/10.1101/2023.08.31.555652

Redpath GMI; Rae J; Yao Y; Ruan J; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti N, Precision Super-Resolution Cryo-Correlative Light and Electron Microscopy for Rapid <i>in situ</i> Structural Analyses of Optogenetically-Positioned Organelles, http://dx.doi.org/10.2139/ssrn.4309027

Redpath GMI; Rae J; Yao Y; Ruan J; Cagigas ML; Whan R; Hardeman EC; Gunning PW; Ananthanarayanan V; Parton RG; Ariotti NA, Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles, http://dx.doi.org/10.1101/2022.11.22.516823

Kumari R; Ven K; Chastney M; Peränen J; Aaron J; Almeida-Souza L; Kremneva E; Poincloux R; Chew T-L; Gunning PW; Ivaska J; Lappalainen P, Specialized actin nanoscale layers control focal adhesion turnover, http://dx.doi.org/10.1101/2023.02.15.528622

Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, Tropomyosin Tpm3.1 is required to maintain the structure and function of the axon initial segment, http://dx.doi.org/10.1101/711614

Kokkinos J; Sharbeen G; Ignacio RMC; Pandzic E; Youkhana J; Boyer C; Haghighi KS; Gunawarman M; Goldstein D; Gebski V; Pajic M; Pitiyarachchi O; Davis ME; Schulstad G; Arkell OSM; Kopecky C; Gonzales-Aloy E; Erkan M; Morton JP; Kavallaris M; Gunning PW; Hardeman EC; Johns A; Gill AJ; Whan RM; Mawson A; Initiative APCG; McCarroll JA; Phillips PA, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, http://dx.doi.org/10.1101/2022.09.29.510034

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