By Professor Peter Gunning

Journal articles

Desouza-Armstrong M; Gunning PW; Stehn JR, 2017, 'Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins', Cytoskeleton, 74, pp. 233 - 248, http://dx.doi.org/10.1002/cm.21367

Gateva G; Kremneva E; Reindl T; Kotila T; Kogan K; Gressin L; Gunning PW; Manstein DJ; Michelot A; Lappalainen P, 2017, 'Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro', Current Biology, 27, pp. 705 - 713, http://dx.doi.org/10.1016/j.cub.2017.01.018

Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154

Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033

Jeong SY; Lim SY; Schevzov G; Gunning PW; Helfman DM, 2017, 'Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling', Oncotarget, 8, pp. 33544 - 33559, http://dx.doi.org/10.18632/oncotarget.16825

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'Cover Image, Volume 74, Issue 10', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21413

Desouza‐Armstrong M; Gunning PW; Stehn JR, 2017, 'Cover Image, Volume 74, Issue 6', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21376

Desouza‐Armstrong M; Gunning PW; Stehn JR, 2017, 'Cover Image, Volume 74, Issue 6', Cytoskeleton, 74, http://dx.doi.org/10.1002/cm.21375

Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342

Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, 11, pp. e0168203, http://dx.doi.org/10.1371/journal.pone.0168203

Gunning P; Shivashankar GV, 2016, 'Letter from the editors', BioArchitecture, 6, pp. 105, http://dx.doi.org/10.1080/19490992.2016.1291050

Chen Y; Gu M; Gunning PW; Russell SM, 2016, 'Dense small molecule labeling enables activator-dependent STORM by proximity mapping', Histochemistry and Cell Biology, 146, pp. 255 - 266, http://dx.doi.org/10.1007/s00418-016-1451-6

Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', BioArchitecture, 6, pp. 61 - 75, http://dx.doi.org/10.1080/19490992.2016.1201619

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, pp. 19816, http://dx.doi.org/10.1038/srep19816

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342

Dugina V; Alieva I; Khromova N; Kireev I; Gunning PW; Kopnin P, 2016, 'Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and γ-actin in epithelial cells', Oncotarget, 7, pp. 72699 - 72715, http://dx.doi.org/10.18632/oncotarget.12236

Knothe Tate ML; Gunning PW; Sansalone V, 2016, 'Emergence of form from function: role of stem cell mechanoadaptation in sealing of cell fate', Bioarchitecture

Coombes JD; Schevzov G; Kan CY; Petti C; Maritz MF; Whittaker S; Mackenzie KL; Gunning PW, 2015, 'Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout', Cellular and Molecular Biology Letters, 20, pp. 626 - 646, http://dx.doi.org/10.1515/cmble-2015-0037

Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, 15, http://dx.doi.org/10.1186/s12885-015-1741-8

Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC; Yang Ai S, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282

Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188

Prunotto M; Bruschi M; Gunning P; Gabbiani G; Weibel F; Ghiggeri GM; Petretto A; Scaloni A; Bonello T; Schevzov G; Alieva I; Bochaton-Piallat ML; Candiano G; Dugina V; Chaponnier C, 2015, 'Stable incorporation of α-smooth muscle actin into stress fibers is dependent on specific tropomyosin isoforms', Cytoskeleton, 72, pp. 257 - 267, http://dx.doi.org/10.1002/cm.21230

Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, 10, pp. e0126214, http://dx.doi.org/10.1371/journal.pone.0126214

Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453

Geeves MA; Hitchcock-DeGregori SE; Gunning PW, 2015, 'A systematic nomenclature for mammalian tropomyosin isoforms', Journal of Muscle Research and Cell Motility, 36, pp. 147 - 153, http://dx.doi.org/10.1007/s10974-014-9389-6

Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hu M; Kramer B; Zhang GY; Wang YM; Watson D; Howden B; McCowage G; Alexander IE; Gunning P; Alexander SI, 2015, 'Methyl-guanine-methyl-transferase transgenic bone marrow transplantation allows N, N-bis (2-chloroethyl)-nitrosourea driven donor mixed-chimerism without graft-versus-host disease, and with donor-specific allograft tolerance', Transplantation, 99, pp. 2476 - 2484, http://dx.doi.org/10.1097/TP.0000000000000825

Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gunning PW; Ghoshdastider U; Whitaker S; Popp D; Robinson RC, 2015, 'The evolution of compositionally and functionally distinct actin filaments', Journal of Cell Science, 128, pp. 2009 - 2019, http://dx.doi.org/10.1242/jcs.165563

Lim CY; Bi X; Wu D; Kim JB; Gunning PW; Hong W; Han W, 2015, 'Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms6951

Pleines I; Woods J; Turro E; Foad N; Chappaz S; Lane RM; Manning H; Schevzov G; Westbury SK; Mumford AD; Favier R; Gunning P; Ouwehand WH; Tijssen MR; Kile BT, 2014, 'Mutations in Tropomyosin 4 Cause Macrothrombocytopenia in Mice and Humans', BLOOD, 124, http://dx.doi.org/10.1182/blood.V124.21.571.571

Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202

Stehn JR; Chen D; Currier MA; Eaves D; Desouza M; Moosavian M; Cripe TP; Gunning PW, 2014, 'Synergistic anti-neuroblastoma efficacy using combinatorial cytoskeletal inhibitors', CANCER RESEARCH, 74, http://dx.doi.org/10.1158/1538-7445.PEDCAN-B50

Vindin H; Bischof L; Gunning P; Stehn J, 2014, 'Validation of an algorithm to quantify changes in actin cytoskeletal organization', Journal of Biomolecular Screening, 19, pp. 354 - 368, http://dx.doi.org/10.1177/1087057113503494

Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293

Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011

Desouza M; Nguyen M; Gunning PW; Stehn JR, 2013, 'Targeting the actin cytoskeleton of neuroblastoma: Elucidating the mechanism by which a novel class of anti-cancer compounds induces tumor cell death.', MOLECULAR CANCER THERAPEUTICS, 12, http://dx.doi.org/10.1158/1535-7163.TARG-13-C208

Koestler SA; Steffen A; Nemethova M; Winterhoff M; Luo N; Holleboom JM; Krupp J; Jacob S; Vinzenz M; Schur F; Schlüter K; Gunning PW; Winkler C; Schmeiser C; Faix J; Stradal TEB; Small JV; Rottner K, 2013, 'Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin', Molecular Biology of the Cell, 24, pp. 2861 - 2875, http://dx.doi.org/10.1091/mbc.E12-12-0857

Vindin H; Gunning P, 2013, 'Cytoskeletal tropomyosins: Choreographers of actin filament functional diversity', Journal of Muscle Research and Cell Motility, 34, pp. 261 - 274, http://dx.doi.org/10.1007/s10974-013-9355-8

Pleines I; Chappaz S; Lane R; Kostadima MA; Schevzov G; Ghevaert C; Gunning P; Ouwehand WH; Kile BT, 2013, 'Tropomyosin 4 is a novel regulator of platelet production in mice and humans', JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 11, pp. 159 - 160, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331833601360&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287

Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501

Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture', BioArchitecture, 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966

Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489

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