By Professor Robert M Graham

Journal articles

Iismaa SE; Hesselson S; McGrath-Cadell L; Muller DW; Fatkin D; Giannoulatou E; Kovacic J; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women', Heart Lung and Circulation, 30, pp. 27 - 35, http://dx.doi.org/10.1016/j.hlc.2020.05.110

Bax M; Junday K; Hesselson S; Iismaa S; Tarr I; McGrath-Cadell L; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham R, 2021, 'Modelling Spontaneous Coronary Artery Dissection With iPSC-Derived Vascular Cells', Heart, Lung and Circulation, 30, pp. S131 - S131, http://dx.doi.org/10.1016/j.hlc.2021.06.089

McGrath-Cadell L; Iismaa SE; Hesselson S; Muller DW; Fatkin D; Giannoulatou E; Kovacic JC; Graham RM, 2021, 'Recent Updates on Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia', International Journal of Integrative Cardiology, 3, http://dx.doi.org/10.47275/2690-862x-121

Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, 2020, 'DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling', Scientific Reports, 10, pp. 21918, http://dx.doi.org/10.1038/s41598-020-78825-x

Nicks AM; Kesteven SH; Li M; Wu J; Chan AY; Naqvi N; Husain A; Feneley MP; Smith NJ; Iismaa SE; Graham RM, 2020, 'Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-72273-3

Carss KJ; Baranowska AA; Armisen J; Webb TR; Hamby SE; Premawardhana D; Al-Hussaini A; Wood A; Wang Q; Deevi SVV; Vitsios D; Lewis SH; Kotecha D; Bouatia-Naji N; Hesselson S; Iismaa SE; Tarr I; McGrath-Cadell L; Muller DW; Dunwoodie SL; Fatkin D; Graham RM; Giannoulatou E; Samani NJ; Petrovski S; Haefliger C; Adlam D, 2020, 'Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing', Circulation: Genomic and Precision Medicine, 13, pp. E003030, http://dx.doi.org/10.1161/CIRCGEN.120.003030

Coleman JLJ; Ngo T; Smythe RE; Cleave AJ; Jones NM; Graham RM; Smith NJ, 2020, 'The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-76384-9

Suzuki AS; Yagi R; Kimura MY; Iwamura C; Shinoda K; Onodera A; Hirahara K; Tumes DJ; Koyama-Nasu R; Iismaa SE; Graham RM; Motohashi S; Nakayama T, 2020, 'Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation', Frontiers in Immunology, 11, http://dx.doi.org/10.3389/fimmu.2020.01536

Thavapalachandran S; Grieve SM; Hume RD; Le TYL; Raguram K; Hudson JE; Pouliopoulos J; Figtree GA; Dye RP; Barry AM; Brown P; Lu J; Coffey S; Kesteven SH; Mills RJ; Rashid FN; Taran E; Kovoor P; Thomas L; Denniss AR; Kizana E; Asli NS; Xaymardan M; Feneley MP; Graham RM; Harvey RP; Chong JJH, 2020, 'Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction', Science Translational Medicine, 12, http://dx.doi.org/10.1126/scitranslmed.aay2140

Situ Y; Baric J; Han W; Law M; Fatkin D; Graham R, 2020, '055 Prevalence and Patient Awareness of Cardiovascular Risk Factors in a Community-Based Australian Cohort', Heart, Lung and Circulation, 29, pp. S62 - S62, http://dx.doi.org/10.1016/j.hlc.2020.09.062

Coleman J; Ngo T; Smythe R; Cleave A; Jones N; Graham R; Smith N, 2020, 'The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases', , http://dx.doi.org/10.1101/2020.06.27.174847

Tan L; Bogush N; Naqvi E; Calvert J; Graham R; Taylor R; Naqvi N; Husain A, 2020, 'Thyroid hormone (T3) plus dual-specificity phosphatase-5 siRNA therapy regenerates the myocardium lost as a result of doxorubicin cardiotoxicity', , http://dx.doi.org/10.21203/rs.3.rs-59095/v1

Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2019, 'Retraction: Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity (Science Signaling (2016) 9 (ra36) DOI: 10.1126/scisignal.aad1089)', Science Signaling, 12, http://dx.doi.org/10.1126/scisignal.aba2063

Mishra K; Junday K; Wong CMY; Chan AY; Hesselson S; Muller DW; Iismaa SE; Mehta A; Graham RM, 2019, 'Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection', Stem Cell Research, 41, http://dx.doi.org/10.1016/j.scr.2019.101584

Tan L; Bogush N; Naib H; Perry J; Calvert JW; Martin DIK; Graham RM; Naqvi N; Husain A, 2019, 'Redox activation of JNK2α2 mediates thyroid hormone-stimulated proliferation of neonatal murine cardiomyocytes', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-53705-1

McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'P5540Familial clustering of spontaneous coronary artery dissection', European Heart Journal, 40, http://dx.doi.org/10.1093/eurheartj/ehz746.0486

Altosaar K; Balaji P; Bond RA; Bylund DB; Cotecchia S; Devost D; Doze VA; Eikenburg DC; Gora S; Goupil E; Graham RM; Hébert T; Hieble JP; Hills R; Kan S; Machkalyan G; Michel MC; Minneman KP; Parra S; Perez D; Sleno R; Summers R; Zylbergold P, 2019, 'Adrenoceptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database', IUPHAR/BPS Guide to Pharmacology CITE, 2019, http://dx.doi.org/10.2218/gtopdb/f4/2019.4

Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', Circulation Research, 125, http://dx.doi.org/10.1161/res.125.suppl_1.579

Alankarage D; Ip E; Szot JO; Munro J; Blue GM; Harrison K; Cuny H; Enriquez A; Troup M; Humphreys DT; Wilson M; Harvey RP; Sholler GF; Graham RM; Ho JWK; Kirk EP; Pachter N; Chapman G; Winlaw DS; Giannoulatou E; Dunwoodie SL, 2019, 'Identification of clinically actionable variants from genome sequencing of families with congenital heart disease', Genetics in Medicine, 21, pp. 1111 - 1120, http://dx.doi.org/10.1038/s41436-018-0296-x

Chew HC; Iyer A; Connellan M; Scheuer S; Villanueva J; Gao L; Hicks M; Harkness M; Soto C; Dinale A; Nair P; Watson A; Granger E; Jansz P; Muthiah K; Jabbour A; Kotlyar E; Keogh A; Hayward C; Graham R; Spratt P; Macdonald P; Dhital K, 2019, 'Outcomes of Donation After Circulatory Death Heart Transplantation in Australia', Journal of the American College of Cardiology, 73, pp. 1447 - 1459, http://dx.doi.org/10.1016/j.jacc.2018.12.067

Serrano RL; Yu W; Graham RM; Liu- Bryan R; Terkeltaub R, 2019, 'A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia', PLoS ONE, 14, http://dx.doi.org/10.1371/journal.pone.0212235

Figtree GA; Jennings G; Nicholls S; Graham RM, 2019, 'The Australian Cardiovascular Alliance–Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden', Heart Lung and Circulation, 28, pp. 198 - 203, http://dx.doi.org/10.1016/j.hlc.2018.12.002

Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Motreff P; Belle L; Dupouy P; Barnay P; Meneveau N; Gilard M; Rioufol G; Range G; Brunel P; Delarche N; Filippi E; Le Bivic L; Harbaoui B; Benamer H; Cayla G; Varenne O; Manzo-Silberman SP; Silvain J; Spaulding C; Caussin C; Gerbaud E; Valy Y; Koning R; Lhermusier T; Champin S; Salengro E; Fluttaz A; Zabalawi A; Cottin Y; Teiger E; Saint-Etienne C; Ducrocq G; Marliere S; Boiffard E; Aubry P; Georges JL; Bresson D; De Poli F; Karrillon G; Roule V; Bali L; Valla M; Gerbay A; Houpe D; Dubreuil O; Monnier A; Mayaud N; Manchuelle A; Commeau P; Bedossa M; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085

McGrath-Cadell L; Hesselson S; Iismaa S; Mishra K; Wong C; Fatkin D; Dunwoodie S; Harvey R; Holloway C; Muller D; Giannoulatou E; Graham R, 2019, 'Familial Clustering of Spontaneous Coronary Artery Dissection', Heart, Lung and Circulation, 28, pp. S330 - S330, http://dx.doi.org/10.1016/j.hlc.2019.06.454

Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, 8, pp. 6114, http://dx.doi.org/10.1038/s41598-018-24525-6

Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', npj Regenerative Medicine, 3, pp. 6, http://dx.doi.org/10.1038/s41536-018-0044-5

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y

Graham RM; McGrath-Cadell L; Muller DWM; Holloway CJ, 2018, 'The Mystery and Enigma of Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 27, pp. 401 - 405, http://dx.doi.org/10.1016/S1443-9506(18)30060-X

Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation. Genomic and precision medicine, 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978

Thavapalachandran S; Grieve S; Le L; Figtree G; Pouliopoulos J; Barry A; Brown P; Lu J; Raguram K; Kovoor P; Denniss R; Sindone A; Kizana E; Feneley M; Graham R; Harvey R; Chong J, 2018, 'Recombinant Human Platelet-Derived Growth Factor AB Improves Cardiac Function and Decreases Ventricular Arrhythmias by Modulating Scar and Angiogenesis After Myocardial Infarction', Heart, Lung and Circulation, 27, pp. S41 - S41, http://dx.doi.org/10.1016/j.hlc.2018.06.002

Ngo T; Ilatovskiy AV; Stewart AG; Coleman JLJ; McRobb FM; Riek RP; Graham RM; Abagyan R; Kufareva I; Smith NJ, 2017, 'Orphan receptor ligand discovery by pickpocketing pharmacological neighbors', Nature Chemical Biology, 13, pp. 235 - 242, http://dx.doi.org/10.1038/nchembio.2266

Guers J; Yoon S; Zhang J; Zhao X; Vatner DE; Graham R; Vatner SF, 2017, 'A1A-ADRENERGIC RECEPTOR OVEREXPRESSION PROTECTS AGAINST THE DEVELOPMENT OF ARRHYTHMIAS FOLLOWING CORONARY ARTERY OCCLUSION', Journal of the American College of Cardiology, 69, pp. 465 - 465, http://dx.doi.org/10.1016/s0735-1097(17)33854-8

Asli N; Xaymardan M; Patrick R; Farbehi N; Cornwell J; Forte E; Waardenberg A; Janbandhu V; Kesteven S; Chandrakanthan V; Malinowska H; Reinhard H; Schofield P; Christ D; Ahmed I; Bouveret R; Srivastava S; Mishra R; Dhawan J; Chong JJH; Nordon R; Macdonald P; Graham R; Feneley M; Harvey R, 2017, 'PDGFRα signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair', , http://dx.doi.org/10.1101/225979

Iyer A; Chew HC; Gao L; Villanueva J; Hicks M; Doyle A; Kumarasinghe G; Jabbour A; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; Macdonald PS, 2016, 'Pathophysiological Trends during Withdrawal of Life Support: Implications for Organ Donation after Circulatory Death', Transplantation, 100, pp. 2621 - 2629, http://dx.doi.org/10.1097/TP.0000000000001396

Tay EMY; Graham RI; Day RO, 2016, 'Severe GHB withdrawal delirium managed with dexmedetomidine', Medical Journal of Australia, 205, pp. 251 - 252.e1, http://dx.doi.org/10.5694/MJA16.00269

Graham RM, 2016, 'The Victor Chang cardiac research institute: Australia's premier organization addressing cardiovascular diseases at the cellular and molecular level', European Heart Journal, 37, pp. 2566 - 2567, http://dx.doi.org/10.1093/eurheartj/ehw317

McGrath-Cadell L; McKenzie P; Emmanuel S; Muller DWM; Graham RM; Holloway CJ, 2016, 'Outcomes of patients with spontaneous coronary artery dissection', OPEN HEART, 3, http://dx.doi.org/10.1136/openhrt-2016-000491

Shi H; O’Reilly VC; Moreau JLM; Bewes TR; Yam MX; Chapman BE; Grieve SM; Stocker R; Graham RM; Chapman G; Sparrow DB; Dunwoodie SL, 2016, 'Gestational stress induces the unfolded protein response, resulting in heart defects', Development (Cambridge), 143, pp. 2561 - 2572, http://dx.doi.org/10.1242/dev.136820

Tejada T; Tan L; Torres RA; Calvert JW; Lambert JP; Zaidi M; Husain M; Berce MD; Naib H; Pejler G; Abrink M; Graham RM; Lefer DJ; Naqvi N; Husain A, 2016, 'IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 6949 - 6954, http://dx.doi.org/10.1073/pnas.1603127113

McNamara JW; Li A; Smith NJ; Lal S; Graham RM; Kooiker KB; van Dijk SJ; Remedios CGD; Harris SP; Cooke R, 2016, 'Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes', Journal of Molecular and Cellular Cardiology, 94, pp. 65 - 71, http://dx.doi.org/10.1016/j.yjmcc.2016.03.009

Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010

Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2016, 'Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity', Science Signaling, 9, http://dx.doi.org/10.1126/scisignal.aad1089

MacDiarmid JA; Langova V; Bailey D; Pattison ST; Pattison SL; Christensen N; Armstrong LR; Brahmbhatt VN; Smolarczyk K; Harrison MT; Costa M; Mugridge NB; Sedliarou I; Grimes NA; Kiss DL; Stillman B; Hann CL; Gallia GL; Graham RM; Brahmbhatt H, 2016, 'Targeted doxorubicin delivery to brain tumors via minicells: Proof of principle using dogs with spontaneously occurring tumors as a model', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0151832

Constantine M; Liew CK; Lo V; MacMillan A; Cranfield CG; Sunde M; Whan R; Graham RM; Martinac B, 2016, 'Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19352

Harvey RP; Wystub-Lis K; del Monte-Nieto G; Graham RM; Tzahor E, 2016, 'Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling', Heart Lung and Circulation, 25, pp. 4 - 7, http://dx.doi.org/10.1016/j.hlc.2015.08.014

Ngo T; Kufareva I; Coleman JLJ; Graham RM; Abagyan R; Smith NJ, 2016, 'Identifying ligands at orphan GPCRs: current status using structure-based approaches', British Journal of Pharmacology, 173, pp. 2934 - 2951, http://dx.doi.org/10.1111/bph.13452

Li M; Tejada T; Lambert JP; Nicholson CK; Yahiro E; Ambai VT; Ali SF; Bradley EW; Graham RM; Dell'Italia LJ; Calvert JW; Naqvi N, 2016, 'Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.', Am J Cardiovasc Dis, 6, pp. 118 - 128

Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038

Zhao X; Balaji P; Pachon R; Beniamen DM; Vatner DE; Graham RM; Vatner SF, 2015, 'Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling', Arteriosclerosis, Thrombosis, and Vascular Biology, 35, pp. 2451 - 2459, http://dx.doi.org/10.1161/ATVBAHA.115.305919

Dhital KK; Iyer A; Connellan M; Chew HC; Gao L; Doyle A; Hicks M; Kumarasinghe G; Soto C; Dinale A; Cartwright B; Nair P; Granger E; Jansz P; Jabbour A; Kotlyar E; Keogh A; Hayward C; Graham R; Spratt P; Macdonald P, 2015, 'Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: A case series', The Lancet, 385, pp. 2585 - 2591, http://dx.doi.org/10.1016/S0140-6736(15)60038-1

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