By Professor Robert M Graham

Journal articles

Serrano RL; Yu W; Graham RM; Liu- Bryan R; Terkeltaub R, 2019, 'A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia', Plos One, 14, http://dx.doi.org/10.1371/journal.pone.0212235

Figtree GA; Jennings G; Nicholls S; Graham RM, 2019, 'The Australian Cardiovascular Alliance–Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden', Heart Lung and Circulation, 28, pp. 198 - 203, http://dx.doi.org/10.1016/j.hlc.2018.12.002

Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Olin JW; Gulati RMD; Tweet MS; Hayes SN; Samani NJ; Graham RM; Motreff P; Bouatia-Naji N; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S; Ford I; Franceschini N; Gieger C; Grace C; Gustafsson S; Huang J; Hwang SJ; Kim YK; Kleber ME; Lau KW; Lu X; Lu Y; Lyytikäinen LP; Mihailov E; Morrison A; Pervjakova N; Qu L; Rose LM; Salfati E; Saxena R; Scholz M; Smith AV; Tikkanen E; Uitterlinden A; Yang X; Zhang W; Zhao W; de Andrade M; de Vries PS; van Zuydam NR; Anand SS; Bertram L; Beutner F; Dedoussis G; Frossard P; Gauguier D; Goodall AH; Gottesman O; Haber M; Han BG; Huang J, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085

McGrath-Cadell L; Hesselson S; Iismaa S; Mishra K; Wong C; Fatkin D; Dunwoodie S; Harvey R; Holloway C; Muller D; Giannoulatou E; Graham R, 2019, 'Familial Clustering of Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 28, pp. s330, http://dx.doi.org/10.1016/j.hlc.2019.06.454

Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, 8, pp. 6114, http://dx.doi.org/10.1038/s41598-018-24525-6

Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', Npj Regenerative Medicine, 3, pp. 6, http://dx.doi.org/10.1038/s41536-018-0044-5

Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y

Graham RM; McGrath-Cadell L; Muller DWM; Holloway CJ, 2018, 'The Mystery and Enigma of Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 27, pp. 401 - 405, http://dx.doi.org/10.1016/S1443-9506(18)30060-X

Szot JO; Cuny H; Blue GM; Humphreys DT; Ip E; Harrison K; Sholler GF; Giannoulatou E; Leo P; Duncan EL; Sparrow DB; Ho JWK; Graham RM; Pachter N; Chapman G; Winlaw DS; Dunwoodie SL, 2018, 'A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data', Circulation Genomic and Precision Medicine, 11, pp. e001978, http://dx.doi.org/10.1161/CIRCGEN.117.001978

Thavapalachandran S; Grieve S; Le L; Figtree G; Pouliopoulos J; Barry A; Brown P; Lu J; Raguram K; Kovoor P; Denniss R; Sindone A; Kizana E; Feneley M; Graham R; Harvey R; Chong J, 2018, 'Recombinant Human Platelet-Derived Growth Factor AB Improves Cardiac Function and Decreases Ventricular Arrhythmias by Modulating Scar and Angiogenesis After Myocardial Infarction', Heart, Lung and Circulation, 27, pp. S41 - S41, http://dx.doi.org/10.1016/j.hlc.2018.06.002

Ngo T; Ilatovskiy AV; Stewart AG; Coleman JLJ; McRobb FM; Riek RP; Graham RM; Abagyan R; Kufareva I; Smith NJ, 2017, 'Orphan receptor ligand discovery by pickpocketing pharmacological neighbors', Nature Chemical Biology, 13, pp. 235 - 242, http://dx.doi.org/10.1038/nchembio.2266

Guers J; Yoon S; Zhang J; Zhao X; Vatner DE; Graham R; Vatner SF, 2017, 'A1A-ADRENERGIC RECEPTOR OVEREXPRESSION PROTECTS AGAINST THE DEVELOPMENT OF ARRHYTHMIAS FOLLOWING CORONARY ARTERY OCCLUSION', Journal of the American College of Cardiology, 69, pp. 465, http://dx.doi.org/10.1016/s0735-1097(17)33854-8

Iyer A; Chew HC; Gao L; Villanueva J; Hicks M; Doyle A; Kumarasinghe G; Jabbour A; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; Macdonald PS, 2016, 'Pathophysiological Trends during Withdrawal of Life Support: Implications for Organ Donation after Circulatory Death', Transplantation, 100, pp. 2621 - 2629, http://dx.doi.org/10.1097/TP.0000000000001396

Tay EM; Graham RI; Day RO, 2016, 'Severe GHB withdrawal delirium managed with dexmedetomidine.', Med J Aust, 205, pp. 251 - 252, http://dx.doi.org/10.5694/mja16.00269

Graham RM, 2016, 'The Victor Chang cardiac research institute: Australia's premier organization addressing cardiovascular diseases at the cellular and molecular level', European Heart Journal, 37, pp. 2566 - 2567, http://dx.doi.org/10.1093/eurheartj/ehw317

Shi H; O’Reilly VC; Moreau JLM; Bewes TR; Yam MX; Chapman BE; Grieve SM; Stocker R; Graham RM; Chapman G; Sparrow DB; Dunwoodie SL, 2016, 'Gestational stress induces the unfolded protein response, resulting in heart defects', Development Cambridge, 143, pp. 2561 - 2572, http://dx.doi.org/10.1242/dev.136820

Tejada T; Tan L; Torres RA; Calvert JW; Lambert JP; Zaidi M; Husain M; Berce MD; Naib H; Pejler G; Abrink M; Graham RM; Lefer DJ; Naqvi N; Husain A, 2016, 'IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 6949 - 6954, http://dx.doi.org/10.1073/pnas.1603127113

McNamara JW; Li A; Smith NJ; Lal S; Graham RM; Kooiker KB; van Dijk SJ; Remedios CGD; Harris SP; Cooke R, 2016, 'Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes', Journal of Molecular and Cellular Cardiology, 94, pp. 65 - 71, http://dx.doi.org/10.1016/j.yjmcc.2016.03.009

Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010

Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2016, 'Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity', Science Signaling, 9, http://dx.doi.org/10.1126/scisignal.aad1089

MacDiarmid JA; Langova V; Bailey D; Pattison ST; Pattison SL; Christensen N; Armstrong LR; Brahmbhatt VN; Smolarczyk K; Harrison MT; Costa M; Mugridge NB; Sedliarou I; Grimes NA; Kiss DL; Stillman B; Hann CL; Gallia GL; Graham RM; Brahmbhatt H, 2016, 'Targeted doxorubicin delivery to brain tumors via minicells: Proof of principle using dogs with spontaneously occurring tumors as a model', Plos One, 11, http://dx.doi.org/10.1371/journal.pone.0151832

Constantine M; Liew CK; Lo V; MacMillan A; Cranfield CG; Sunde M; Whan R; Graham RM; Martinac B, 2016, 'Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19352

Harvey RP; Wystub-Lis K; del Monte-Nieto G; Graham RM; Tzahor E, 2016, 'Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling', Heart Lung and Circulation, 25, pp. 4 - 7, http://dx.doi.org/10.1016/j.hlc.2015.08.014

Ngo T; Kufareva I; Coleman JLJ; Graham RM; Abagyan R; Smith NJ, 2016, 'Identifying ligands at orphan GPCRs: current status using structure-based approaches', British Journal of Pharmacology, 173, pp. 2934 - 2951, http://dx.doi.org/10.1111/bph.13452

Li M; Tejada T; Lambert JP; Nicholson CK; Yahiro E; Ambai VT; Ali SF; Bradley EW; Graham RM; Dell'Italia LJ; Calvert JW; Naqvi N, 2016, 'Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.', Am J Cardiovasc Dis, 6, pp. 118 - 128

McGrath-Cadell L; McKenzie P; Emmanuel S; Muller DWM; Graham RM; Holloway CJ, 2016, 'Outcomes of patients with spontaneous coronary artery dissection', Open Heart, 3, pp. e000491, http://dx.doi.org/10.1136/openhrt-2016-000491

Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038

Zhao X; Balaji P; Pachon R; Beniamen DM; Vatner DE; Graham RM; Vatner SF, 2015, 'Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling', Arteriosclerosis Thrombosis and Vascular Biology, 35, pp. 2451 - 2459, http://dx.doi.org/10.1161/ATVBAHA.115.305919

Dhital KK; Iyer A; Connellan M; Chew HC; Gao L; Doyle A; Hicks M; Kumarasinghe G; Soto C; Dinale A; Cartwright B; Nair P; Granger E; Jansz P; Jabbour A; Kotlyar E; Keogh A; Hayward C; Graham R; Spratt P; Macdonald P, 2015, 'Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: A case series', Lancet, 385, pp. 2585 - 2591, http://dx.doi.org/10.1016/S0140-6736(15)60038-1

Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069

Coleman JLJ; Brennan K; Ngo T; Balaji P; Graham RM; Smith NJ, 2015, 'Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: A case study', Frontiers in Endocrinology, 6, pp. 105, http://dx.doi.org/10.3389/fendo.2015.00105

Iyer A; Gao L; Doyle A; Rao P; Cropper JR; Soto C; Dinale A; Kumarasinghe G; Jabbour A; Hicks M; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; MacDonald PS, 2015, 'Normothermic Ex Vivo Perfusion Provides Superior Organ Preservation and Enables Viability Assessment of Hearts From DCD Donors', American Journal of Transplantation, 15, pp. 371 - 380, http://dx.doi.org/10.1111/ajt.12994

Zhao X; Pachon R; Yan L; Lee G; Sui X; Beniamen D; Balaji P; Ho D; Vatner DE; Graham RM; Vatner SF, 2014, 'Abstract 18134: Cardiomyocyte Overexpression of the alpha1A-Adrenergic Receptor in the Rat Protects Post-Infarct Heart Failure through Angiogenesis and the MEK-ERK Pathway', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.18134

Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001

Harvey RP; Graham RM; Pu WT, 2014, 'Introduction to the Special Issue on Heart Regeneration and Rejuvenation', Stem Cell Research, http://dx.doi.org/10.1016/j.scr.2014.10.003

Navarini AA; Simpson MA; Weale M; Knight J; Carlavan I; Reiniche P; Burden DA; Layton A; Bataille V; Allen M; Pleass R; Pink A; Creamer D; English J; Munn S; Walton S; Willis C; Akhras V; Alexandroff A; Anstey A; Azad J; Aziz O; Baudry D; Burrows N; Butt A; Cartwright P; Chapman A; Clayton T; Cliff S; Cunliffe W; Cutler T; Daly B; Damian E; Darvay A; DeGiovanni C; Downs A; Duckworth M; Dwyer C; Ferguson A; Fleming C; Fox Z; Frazer-Andrews E; Gonzalez J; Goodfield M; Graham R; Grattan C; Green N; Hazelwood-Smith S; Hempel H; Hood S; Hughes B; Ladoyanni E; Lyon C; Mahmud A; Malik M; Meggitt S; Messenger A; Moosa Y; Ormerod A; Patel V; Rallan D; Robertson S; Ross J; Salvary I; Wachsmuth R; Wahie S; Williamson D; Déret S; Voegel JJ; Spector T; Smith CH; Trembath RC; Barker JN, 2014, 'Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms5020

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', Plos One, 9, pp. e99024, http://dx.doi.org/10.1371/journal.pone.0099024

Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035

Iyer A; Gao L; Doyle A; Rao P; Jayewardene D; Wan B; Kumarasinghe G; Jabbour A; Hicks M; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; Macdonald PS, 2014, 'Increasing the Tolerance of DCD Hearts to Warm Ischemia by Pharmacological Postconditioning', American Journal of Transplantation, 14, pp. 1744 - 1752, http://dx.doi.org/10.1111/ajt.12782

Chalmers J; Angus J; Graham R; Carmody J; Dampney R; Jennings G; Korner N, 2013, 'Paul Ivan Korner 1925-2012', HISTORICAL RECORDS OF AUSTRALIAN SCIENCE, 24, pp. 251 - 282, http://dx.doi.org/10.1071/HR13008

Costa MW; Guo G; Wolstein O; Vale M; Castro ML; Wang L; Otway R; Riek P; Cochrane N; Furtado M; Semsarian C; Weintraub RG; Yeoh T; Hayward C; Keogh A; Macdonald P; Feneley M; Graham RM; Seidman JG; Seidman CE; Rosenthal N; Fatkin D; Harvey RP, 2013, 'Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.', Circ Cardiovasc Genet, 6, pp. 238 - 247, http://dx.doi.org/10.1161/CIRCGENETICS.113.000057

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Mohl MC; Graham RM, 2012, 'α1-Adrenergic Receptors', , pp. 51 - 54, http://dx.doi.org/10.1016/B978-0-12-386525-0.00009-3

Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96

Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011

Mohl M; Xiao X-H; Balaji P; Issmaa S; Feneley M; Graham R, 2012, 'The α 1A‐adrenergic receptor mediates cardiac hypertrophy through the G α q‐PI3K‐Rac1 signaling pathway', The FASEB Journal, 26, http://dx.doi.org/10.1096/fasebj.26.1_supplement.663.4

Graham RM; Harvey RP, 2011, 'The ontogeny of cardiac regeneration', Circulation Research, 108, pp. 1304 - 1305, http://dx.doi.org/10.1161/RES.0b013e318222ba1a

Jabbour A; Gao L; Kwan J; Watson A; Sun L; Qiu MR; Liu X; Zhou MD; Graham RM; Hicks M; MacDonald PS, 2011, 'A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage.', Transplantation, 91, pp. 961 - 967, http://dx.doi.org/10.1097/TP.0b013e3182115b4b

Skellett A; Gibbs S; Handfield-Jones S; Graham R; Tan E; Garioch J, 2011, 'Management of melanomas in primary care', British Journal of Dermatology, 164, pp. 680 - 682, http://dx.doi.org/10.1111/j.1365-2133.2010.10106.x

Cannon L; Marciniec T; Mearns B; Vale M; Nikolova-Krstevski V; Kesteven S; Raynor S; Feneley M; Graham R; Fatkin D, 2011, 'A Regulatable Model of Mutant α-Myosin Heavy Chain Overexpression to Study the Structural and Functional Consequences of Hypertrophy Regression', Heart, Lung and Circulation, 20, pp. S1 - S1, http://dx.doi.org/10.1016/j.hlc.2011.05.004

Back to profile page