By Professor Robert M Graham

Journal articles

Soetanto R; Hynes CJ; Patel HR; Humphreys DT; Evers M; Duan G; Parker BJ; Archer SK; Clancy JL; Graham RM; Beilharz TH; Smith NJ; Preiss T, 2016, 'Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1859, pp. 744 - 756, http://dx.doi.org/10.1016/j.bbagrm.2016.03.010

Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2016, 'Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity', Science Signaling, 9, http://dx.doi.org/10.1126/scisignal.aad1089

MacDiarmid JA; Langova V; Bailey D; Pattison ST; Pattison SL; Christensen N; Armstrong LR; Brahmbhatt VN; Smolarczyk K; Harrison MT; Costa M; Mugridge NB; Sedliarou I; Grimes NA; Kiss DL; Stillman B; Hann CL; Gallia GL; Graham RM; Brahmbhatt H, 2016, 'Targeted doxorubicin delivery to brain tumors via minicells: Proof of principle using dogs with spontaneously occurring tumors as a model', PLoS ONE, 11, http://dx.doi.org/10.1371/journal.pone.0151832

Constantine M; Liew CK; Lo V; MacMillan A; Cranfield CG; Sunde M; Whan R; Graham RM; Martinac B, 2016, 'Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer', Scientific Reports, 6, http://dx.doi.org/10.1038/srep19352

Harvey RP; Wystub-Lis K; del Monte-Nieto G; Graham RM; Tzahor E, 2016, 'Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling', Heart Lung and Circulation, 25, pp. 4 - 7, http://dx.doi.org/10.1016/j.hlc.2015.08.014

Ngo T; Kufareva I; Coleman JLJ; Graham RM; Abagyan R; Smith NJ, 2016, 'Identifying ligands at orphan GPCRs: current status using structure-based approaches', British Journal of Pharmacology, 173, pp. 2934 - 2951, http://dx.doi.org/10.1111/bph.13452

Li M; Tejada T; Lambert JP; Nicholson CK; Yahiro E; Ambai VT; Ali SF; Bradley EW; Graham RM; Dell'Italia LJ; Calvert JW; Naqvi N, 2016, 'Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ.', Am J Cardiovasc Dis, 6, pp. 118 - 128

Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038

Zhao X; Balaji P; Pachon R; Beniamen DM; Vatner DE; Graham RM; Vatner SF, 2015, 'Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling', Arteriosclerosis, Thrombosis, and Vascular Biology, 35, pp. 2451 - 2459, http://dx.doi.org/10.1161/ATVBAHA.115.305919

Dhital KK; Iyer A; Connellan M; Chew HC; Gao L; Doyle A; Hicks M; Kumarasinghe G; Soto C; Dinale A; Cartwright B; Nair P; Granger E; Jansz P; Jabbour A; Kotlyar E; Keogh A; Hayward C; Graham R; Spratt P; Macdonald P, 2015, 'Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: A case series', The Lancet, 385, pp. 2585 - 2591, http://dx.doi.org/10.1016/S0140-6736(15)60038-1

Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069

Coleman JLJ; Brennan K; Ngo T; Balaji P; Graham RM; Smith NJ, 2015, 'Rapid knockout and reporter mouse line generation and breeding colony establishment using EUCOMM conditional-ready embryonic stem cells: A case study', Frontiers in Endocrinology, 6, pp. 105, http://dx.doi.org/10.3389/fendo.2015.00105

Iyer A; Gao L; Doyle A; Rao P; Cropper JR; Soto C; Dinale A; Kumarasinghe G; Jabbour A; Hicks M; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; MacDonald PS, 2015, 'Normothermic Ex Vivo Perfusion Provides Superior Organ Preservation and Enables Viability Assessment of Hearts From DCD Donors', American Journal of Transplantation, 15, pp. 371 - 380, http://dx.doi.org/10.1111/ajt.12994

Zhao X; Pachon R; Yan L; Lee G; Sui X; Beniamen D; Balaji P; Ho D; Vatner DE; Graham RM; Vatner SF, 2014, 'Abstract 18134: Cardiomyocyte Overexpression of the alpha1A-Adrenergic Receptor in the Rat Protects Post-Infarct Heart Failure through Angiogenesis and the MEK-ERK Pathway', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.18134

Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001

Harvey RP; Graham RM; Pu WT, 2014, 'Introduction to the Special Issue on Heart Regeneration and Rejuvenation', Stem Cell Research, http://dx.doi.org/10.1016/j.scr.2014.10.003

Navarini AA; Simpson MA; Weale M; Knight J; Carlavan I; Reiniche P; Burden DA; Layton A; Bataille V; Allen M; Pleass R; Pink A; Creamer D; English J; Munn S; Walton S; Willis C; Akhras V; Alexandroff A; Anstey A; Azad J; Aziz O; Baudry D; Burrows N; Butt A; Cartwright P; Chapman A; Clayton T; Cliff S; Cunliffe W; Cutler T; Daly B; Damian E; Darvay A; DeGiovanni C; Downs A; Duckworth M; Dwyer C; Ferguson A; Fleming C; Fox Z; Frazer-Andrews E; Gonzalez J; Goodfield M; Graham R; Grattan C; Green N; Hazelwood-Smith S; Hempel H; Hood S; Hughes B; Ladoyanni E; Lyon C; Mahmud A; Malik M; Meggitt S; Messenger A; Moosa Y; Ormerod A; Patel V; Rallan D; Robertson S; Ross J; Salvary I; Wachsmuth R; Wahie S; Williamson D; Déret S; Voegel JJ; Spector T; Smith CH; Trembath RC; Barker JN, 2014, 'Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms5020

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, 9, pp. e99024, http://dx.doi.org/10.1371/journal.pone.0099024

Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035

Iyer A; Gao L; Doyle A; Rao P; Jayewardene D; Wan B; Kumarasinghe G; Jabbour A; Hicks M; Jansz PC; Feneley MP; Harvey RP; Graham RM; Dhital KK; Macdonald PS, 2014, 'Increasing the Tolerance of DCD Hearts to Warm Ischemia by Pharmacological Postconditioning', American Journal of Transplantation, 14, pp. 1744 - 1752, http://dx.doi.org/10.1111/ajt.12782

Costa MW; Guo G; Wolstein O; Vale M; Castro ML; Wang L; Otway R; Riek P; Cochrane N; Furtado M; Semsarian C; Weintraub RG; Yeoh T; Hayward C; Keogh A; Macdonald P; Feneley M; Graham RM; Seidman JG; Seidman CE; Rosenthal N; Fatkin D; Harvey RP, 2013, 'Functional Characterization of a Novel Mutation in NKX2-5 Associated With Congenital Heart Disease and Adult-Onset Cardiomyopathy', Circulation: Cardiovascular Genetics, 6, pp. 238 - 247, http://dx.doi.org/10.1161/CIRCGENETICS.113.000057

Chalmers J; Angus J; Graham R; Carmody J; Dampney R; Jennings G; Korner N, 2013, 'Paul Ivan Korner 1925-2012', HISTORICAL RECORDS OF AUSTRALIAN SCIENCE, 24, pp. 251 - 282, http://dx.doi.org/10.1071/HR13008

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Mohl MC; Graham RM, 2012, 'α1-Adrenergic Receptors', , pp. 51 - 54, http://dx.doi.org/10.1016/B978-0-12-386525-0.00009-3

Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96

Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011

Mohl M; Xiao X-H; Balaji P; Issmaa S; Feneley M; Graham R, 2012, 'The α1A‐adrenergic receptor mediates cardiac hypertrophy through the Gαq‐PI3K‐Rac1 signaling pathway', The FASEB Journal, 26, http://dx.doi.org/10.1096/fasebj.26.1_supplement.663.4

Graham RM; Harvey RP, 2011, 'The ontogeny of cardiac regeneration', Circulation Research, 108, pp. 1304 - 1305, http://dx.doi.org/10.1161/RES.0b013e318222ba1a

Skellett A; Gibbs S; Handfield-Jones S; Graham R; Tan E; Garioch J, 2011, 'Management of melanomas in primary care', British Journal of Dermatology, 164, pp. 680 - 682, http://dx.doi.org/10.1111/j.1365-2133.2010.10106.x

Jabbour A; Gao L; Kwan JC; Watson A; Sun L; Qiu ; Liu X; Zhou MD; Graham RM; Hicks M; Macdonald PS, 2011, 'A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage', Transplantation, 91, pp. 961 - 967, http://dx.doi.org/10.1097/TP.0b013e3182115b4b

Cannon L; Marciniec T; Mearns B; Vale M; Nikolova-Krstevski V; Kesteven S; Raynor S; Feneley M; Graham R; Fatkin D, 2011, 'A Regulatable Model of Mutant α-Myosin Heavy Chain Overexpression to Study the Structural and Functional Consequences of Hypertrophy Regression', Heart, Lung and Circulation, 20, pp. S1 - S1, http://dx.doi.org/10.1016/j.hlc.2011.05.004

Riek RP; Graham RM, 2011, 'The elusive π-helix', Journal of Structural Biology, 173, pp. 153 - 160, http://dx.doi.org/10.1016/j.jsb.2010.09.001

Macbeth AE; James A; Rhodes M; Igali L; Mcgibbon D; Graham RM, 2010, 'Necrolytic migratory erythema with the absence of necrolysis', Clinical and Experimental Dermatology, 35, pp. 810 - 811, http://dx.doi.org/10.1111/j.1365-2230.2010.03824.x

Mohl M; Xiao X-H; Prosser H; Iismaa S; Feneley M; Graham R, 2010, 'Involvement of a Novel a1A-Adrenergic Receptor-Coupled Signaling Pathway in Cardiac Contractility', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506325&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zhao X; Vatner DE; Park M; Yan L; IIsmaa S; Graham R; Vatner SF, 2010, 'Transgenic Rats with Cardiac Overexpression of alpha1A Adrenergic Receptors are protected from Myocardial Ischemia by a Nitric Oxide Mechanism', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675500791&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Kirby A; Graham R; Williams NJ; Wootton M; Broughton CM; Alanazi M; Anson J; Neal TJ; Parry CM, 2010, 'Staphylococcus aureus with reduced glycopeptide susceptibility in Liverpool, UK', Journal of Antimicrobial Chemotherapy, 65, pp. 721 - 724, http://dx.doi.org/10.1093/jac/dkq009

Williams H; Pease RJ; Newell LM; Cordell PA; Graham RM; Kearney TK; Jackson CL; Grant PJ, 2010, 'Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse', Atherosclerosis, 210, pp. 94 - 99, http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.014

Chih SS; Macdonald P; McCrohon JA; Ma D; John M; Law M; Feneley MP; Herbert A; Kovacic JC; Graham RM; Victor Chang Cardiac Research Institute , 2010, 'GRANULOCYTE-COLONY STIMULATING FACTOR IN ANGINA PATIENTS WITH ISCHAEMIC HEART DIESASE TO STIMULATE NEOVASCULARISATION (GAIN II TRIAL)', Journal of the American College of Cardiology, 55, pp. A126.E1184 - A126.E1184, http://dx.doi.org/10.1016/s0735-1097(10)61185-0

Jabbour A; Hayward CS; Keogh AM; Kotlyar E; Mccrohon JA; England JF; Amor R; Liu X; Zhou MD; Graham RM; Macdonald PS, 2010, 'Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses', European Journal of Heart Failure, 13, pp. 83 - 92, http://dx.doi.org/10.1093/eurjhf/hfq152

Riek RP; Graham RM, 2010, 'The elusive pi-helix', Journal of Structural Biology, 173, pp. 153 - 160, http://dx.doi.org/10.1016/j.jsb.2010.09.001

Almaani N; Liu L; Dopping-Hepenstal PJC; Lovell PA; Lai-Cheong JE; Graham RM; Mellerio JE; McGrath JA, 2009, 'Autosomal dominant junctional epidermolysis bullosa', British Journal of Dermatology, 160, pp. 1094 - 1097, http://dx.doi.org/10.1111/j.1365-2133.2008.08977.x

Kovacic JC; Macdonald P; Feneley MP; Graham RM, 2009, 'Granulocyte-colony stimulating factor in refractory ischemic heart disease: Throwing stones from glass houses', American Heart Journal, 157, http://dx.doi.org/10.1016/j.ahj.2009.02.009

Jabbour A; Gao L; Kwan J; Watson A; Sun L; Liu X; Zhou M; Graham RM; Hicks M; Macdonald P, 2009, 'A Recombinant Human Neuregulin-1 Peptide Improves Preservation of the Transplanted Rat Heart After Prolonged Hypothermic Storage', Heart, Lung and Circulation, 18, pp. S168 - S168, http://dx.doi.org/10.1016/j.hlc.2009.05.382

Chih S; McCrohon J; Macdonald P; Feneley M; Graham RM, 2009, 'Exercise and Endothelial Progenitor Cells in Patients with Severe Coronary Artery Disease', Heart, Lung and Circulation, 18, pp. S112 - S113, http://dx.doi.org/10.1016/j.hlc.2009.05.255

Kovacic J; Macdonald PS; Feneley MP; Graham RM, 2009, 'Granulocyte-colony stimulating factor in refractory ischemic heart disease: Throwing stones from glass houses', American Heart Journal, 157, pp. e39, http://dx.doi.org/10.1016/j.aucc.2009.06.001

Naqvi N; Li M; Yahiro E; Graham RM; Husain A, 2009, 'Insights into the characteristics of mammalian cardiomyocyte terminal differentiation shown through the study of mice with a dysfunctional c-kit', Pediatric Cardiology, 30, pp. 651 - 658, http://dx.doi.org/10.1007/s00246-008-9366-1

Tatsukawa H; Fukaya Y; Frampton G; Martinez-Fuentes A; Suzuki K; Kuo T; Nagatsuma K; Shimokado K; Okuno M; Wu J; Iismaa SE; Matsuura T; Tsukamoto H; Zern M; Graham RM; Kojima S, 2009, 'Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1', Gastroenterology, 136, pp. 1783 - 1795, http://dx.doi.org/10.1053/j.gastro.2009.01.007

MacDiarmid J; Amaro-Mugridge N; Madrid-Weiss J; Sedliarou I; Wetzel S; Kochar K; Brahmbhatt V; Phillips LN; Pattison S; Petti C; Stillman B; Graham RM; Brahmbhatt H, 2009, 'Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug', Nature Biotechnology, 27, pp. 643 - 651, http://dx.doi.org/10.1038/nbt.1547

Jabbour A; Hayward CS; Keogh AM; Kotlyar E; McCrohon J; England JF; Amor R; Liu X; Graham RM; Macdonald PS, 2009, 'The Safety and Efficacy of Recombinant Human Neuregulin-1 in Patients with Stable Chronic Heart Failure', Heart, Lung and Circulation, 18, pp. S192 - S192, http://dx.doi.org/10.1016/j.hlc.2009.05.436

Iismaa SE; Mearns BM; Lorand L; Graham RM, 2009, 'Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders', Physiological Reviews, 89, pp. 991 - 1023

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