By Professor Robert M Graham

Journal articles

Perez DM; Hwa J; Gaivin R; Mathur M; Brown F; Graham RM, 1996, 'Constitutive activation of a single effector pathway: Evidence for multiple activation states of a G protein-coupled receptor', Molecular Pharmacology, 49, pp. 112 - 122

Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, 'α1-Adrenergic Receptor Subtypes Molecular Structure, Function, and Signaling', Circulation Research, 78, pp. 737 - 749, http://dx.doi.org/10.1161/01.RES.78.5.737

Graham RM; Neubig R; Lynch KR, 1996, 'α2-Adrenoceptors take centre stage at Nashville meeting', Trends in Pharmacological Sciences, 17, pp. 90 - 94, http://dx.doi.org/10.1016/0165-6147(96)30004-7

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, '1-Adrenergic receptor subtypes: molecular structure, function and signalling', Circulation Research, pp. 737 - 749

Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, 271, pp. 32385 - 32391

Hwa J; Graham RM; Perez DM, 1996, 'Chimeras of 1-adrenergic receptor subtypes indentify critical residues that modulate active-state isomerization', The Journal of Biological Chemistry, pp. 7956 - 7964

Perez DM; Hwa J; Gaivin R; Mathur M; Brown F; Graham RM, 1996, 'Consitutive activity of a single transduction pathway due to a point-mutation in the 1B-adrenergic receptor', Molecular Pharmacology, pp. 112 - 122

Pollak MR; Delaney VB; Graham RM; Hebert SC, 1996, 'Gitelman`s syndrome (Bartters variant) maps to the thiazide-sensitive cotransporter gene locus on chromosone 16q13 in a large kindred', Journal of the American Society of Nephrology, pp. 2244 - 2248

Hwa J; Graham RM; Perez DM, 1995, 'Identification of critical determinants of α1-adrenergic receptor subtype selective agonist binding', Journal of Biological Chemistry, 270, pp. 23189 - 23195, http://dx.doi.org/10.1074/jbc.270.39.23189

Graham RM, 1995, 'Left handed GDP's and students.', British dental journal, 178, pp. 326, http://dx.doi.org/10.1038/sj.bdj.4808754

PEREZ DM; HWA J; GAIVIN R; GRAHAM RM, 1995, 'CONSTITUTIVE ACTIVATION OF A SINGLE EFFECTOR PATHWAY - EVIDENCE FOR INDUCED CONFORMATIONAL PLEIOTROPY OF G-PROTEIN-COUPLED RECEPTORS', FASEB JOURNAL, 9, pp. A849 - A849, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QM40601303&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HWA J; REIK RP; GRAHAM RM; PEREZ DM, 1995, 'EFFECTS OF MUTATING SPECIFIC AMINO-ACIDS ON THE LIGAND-BINDING CHARACTERISTICS OF ALPHA(1)-ADRENERGIC RECEPTOR SUBTYPES', FASEB JOURNAL, 9, pp. A104 - A104, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98700609&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Graham RM; Perez DM; Piascik MT; Riek RP; Hwa J, 1995, 'Characterisation of α1-adrenergic receptor subtypes', Pharmacology Communications, 6, pp. 15 - 22

Hasebe N; Hittinger L; Kohin S; Shen YT; Graham RM; Vatner SF, 1995, 'Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs', American Journal of Physiology - Heart and Circulatory Physiology, 268, http://dx.doi.org/10.1152/ajpheart.1995.268.2.h781

Kerr JR; Moore JE; Curran MD; Graham R; Web CH; Lowry KG; Murphy PG; Wilson TS; Ferguson WP, 1995, 'Investigation of a nosocomial outbreak of Pseudomonas aeruginosa pneumonia in an intensive care unit by random amplification of polymorphic DNA assay', Journal of Hospital Infection, 30, pp. 125 - 131, http://dx.doi.org/10.1016/0195-6701(95)90152-3

DeS Senanayake P; Denker J; Bravo EL; Graham RM, 1995, 'Production, characterization, and expression of neuropeptide Y by human pheochromocytoma', Journal of Clinical Investigation, 96, pp. 2503 - 2509, http://dx.doi.org/10.1172/JCI118310

Hwa J; Graham RM; Perez DM, 1995, 'Critical determinants of a -adrenergic receptor subtype-selective ahonist binding', The Journal of Biological Chemistry, pp. 23189 - 23195

Riek RP; Handschumacher MK; Sung S; Tan M; Glynias MJ; Schluchter MD; Novotny J; Graham RM, 1995, 'Evolutionary conservation of both the hydrophilic and hydrophobic nature of transmembrance residues', Journal of Theoretical Biology, 172, pp. 245 - 258

Vincan E; Neylon CB; Graham RM; Woodcock EA, 1995, 'Isolatin of neonatal cardiomyocytes reduces the expression of the GTP-binding protein Gh', Journal of Molecular and Cellular Cardiology, pp. 2393 - 2396

Noda K; Saad YM; Kinoshita A; Graham RM; Boyle T; Husain A; Karnik S, 1995, 'Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms', The Journal of Biological Chemistry, pp. 2284 - 2289

Des Senanayake P; Denker J; Bravo EL; Graham RM, 1995, 'The distribution and release of neuropeptide Y from adrenal and extraadrenal pheochromocytomas', Journal of Clinical Investigation, pp. 2503 - 2509

De Young MB; Kincade-Denker J; Boehm CA; Riek RP; Mamone JA; McSwiggen JA; Graham RM, 1994, 'Functional Characterization of Ribozymes Expressed Using U1 and T7 Vectors for the Intracellular Cleavage of ANF mRNA', Biochemistry, 33, pp. 12127 - 12138, http://dx.doi.org/10.1021/bi00206a016

Casale PN; Fifer MA; Graham RM; Palacios IF, 1994, 'Relation of atrial pressure and plasma level of atrial natriuretic factor in cardiac tamponade', The American Journal of Cardiology, 73, pp. 610 - 613, http://dx.doi.org/10.1016/0002-9149(94)90346-8

Noda K; Saad Y; Graham RM; Karnik SS, 1994, 'The high affinity state of the β2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines', Journal of Biological Chemistry, 269, pp. 6743 - 6752

De Young MB; Keller JC; Graham RM; Wildey GM, 1994, 'Brefeldin A defines distinct pathways for atrial natriuretic factor secretion in neonatal rat atrial and ventricular myocytes', Circulation Research, 74, pp. 33 - 40

Perez DM; Piascik MT; Malik N; Gaivin R; Graham RM, 1994, 'Cloning, expression, and tissue distribution of the rat homolog of the bovine α1C-adrenergic receptor provide evidence for its classification as the α1A subtype', Molecular Pharmacology, 46, pp. 823 - 831

Graham RM, 1994, 'Cyclosporine: Mechanisms of action and toxicity', Cleveland Clinic Journal of Medicine, 61, pp. 308 - 313, http://dx.doi.org/10.3949/ccjm.61.4.308

Nakaoka H; Perez DM; Baek KJ; Das T; Husain A; Misono K; Im MJ; Graham RM, 1994, 'Gh: A GTP-Binding protein with transglutaminase activity and receptor signaling function', Science, 264, pp. 1593 - 1596, http://dx.doi.org/10.1126/science.7911253

Urata H; Karnik SS; Graham RM; Husain A, 1993, 'Dipeptide processing activates recombinant human prochymase', Journal of Biological Chemistry, 268, pp. 24318 - 24322

Perez DM; DeYoung MB; Graham RM, 1993, 'Coupling of expressed α1B- and α1D-adrenergic receptors to multiple signaling pathways is both G protein and cell type specific', Molecular Pharmacology, 44, pp. 784 - 795

Graham RM, 1993, 'F. Merlin Bumpus, PhD.', Cleveland Clinic journal of medicine, 60, pp. 417 - 418

Ramarao CS; Denker JMK; Perez DM; Gaivin RJ; Riek RP; Graham RM, 1992, 'Genomic organization and expression of the human α(1B)-adrenergic receptor', Journal of Biological Chemistry, 267, pp. 21936 - 21945

Kiuchi K; Vatner DE; Uemura N; Bigaud M; Hasebe N; Hempel DM; Graham RM; Vatner SF, 1992, 'Mechanisms of α1-adrenergic vascular desensitization in conscious dogs', Circulation Research, 71, pp. 1185 - 1199

Franke RR, 1992, 'Structure and function in rhodopsin: Studies of the interaction between the rhodopsin cytoplasmic domain and transducin', Journal of Biological Chemistry, 267, pp. 14767 - 14774

Urata H; Kinoshita A; Perez DM; Misono KS; Bumpus FM; Graham RM; Husain A, 1991, 'Cloning of the gene and cDNA for human heart chymase', Journal of Biological Chemistry, 266, pp. 17173 - 17179

Shen YT; Graham RM; Vatner SF, 1991, 'Effects of atrial natriuretic factor on blood flow distribution and vascular resistance in conscious dogs', American Journal of Physiology - Heart and Circulatory Physiology, 260, http://dx.doi.org/10.1152/ajpheart.1991.260.6.h1893

Shannon RP; Gelpi RJ; Hittinger L; Vatner DE; Homcy CJ; Graham RM; Vatner SF, 1991, 'Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension', Circulation Research, 68, pp. 543 - 554, http://dx.doi.org/10.1161/01.RES.68.2.543

Kaye SB; Graham R; McCarthy K; Green JR; Damjanovic V; Austin M, 1991, 'Reducing disinfectant wastage', Eye (Basingstoke), 5, pp. 120 - 123, http://dx.doi.org/10.1038/eye.1991.22

Perez DM; Piascik MT; Graham RM, 1991, 'Solution-phase library screening for the identification of rare clones: Isolation of an α1D-adrenergic receptor cDNA', Molecular Pharmacology, 40, pp. 876 - 883

Im MJ; Graham RM, 1990, 'A novel guanine nucleotide-binding protein coupled to the α1-adrenergic receptor: I. Identification by photolabeling of membrane and ternary complex preparations', Journal of Biological Chemistry, 265, pp. 18944 - 18951

Im MJ; Riek RP; Graham RM, 1990, 'A novel guanine nucleotide-binding protein coupled to the α1-adrenergic receptor: II. Purification, characterization, and reconstitution', Journal of Biological Chemistry, 265, pp. 18952 - 18960

Graham RM, 1990, 'Adrenergic receptors: Structure and function', Cleveland Clinic Journal of Medicine, 57, pp. 481 - 492, http://dx.doi.org/10.3949/ccjm.57.5.481

Shen YT; Young MA; Ohanian J; Graham RM; Vatner SF, 1990, 'Atrial natriuretic factor-induced systemic vasoconstriction in conscious dogs, rats, and monkeys', Circulation Research, 66, pp. 647 - 661, http://dx.doi.org/10.1161/01.RES.66.3.647

Terman BI; Riek RP; Grodski A; Hess HJ; Graham RM, 1990, 'Identification and structural characterization of α1-adrenergic receptor subtypes', Molecular Pharmacology, 37, pp. 526 - 534

Wildey GM; Fischman AJ; Margolies MN; Graham RM; Homcy CJ, 1990, 'Phosphorylation state of pro-atrial natriuretic factor in rat atrial secretory granules', Endocrinology, 127, pp. 2839 - 2848

Graham RM, 1989, 'Selective alpha1-adrenergic blockade, lipids, and coronary heart disease risk. Considerations in the treatment of mild hypertension', The American Journal of Medicine, 87, http://dx.doi.org/10.1016/0002-9343(89)90114-9

Forbes AM; Woodrow JC; Verbov JL; Graham RM, 1989, 'Carcinoma of breast and scleroderma: Four further cases and a literature review', Rheumatology, 28, pp. 65 - 69, http://dx.doi.org/10.1093/rheumatology/28.1.65

Parini A; Graham RM, 1989, 'Glycerol, sodium phosphate, and sodium chloride permit the solubilization and partial purification of rat hepatic α1-receptors by 3-(3-cholamidylpropyl)-dimethylammonio-1-propanesulfonate', Analytical Biochemistry, 176, pp. 375 - 381, http://dx.doi.org/10.1016/0003-2697(89)90327-8

Karge WH; Weiner EJ; Kowala MC; Graham RM; Nicolosi RJ, 1989, 'Effects of prazosin on hemodynamics, hemostasis, and serum lipid and lipoprotein levels in normal and hypercholesterolemic monkeys', The American Journal of Medicine, 86, pp. 19 - 23, http://dx.doi.org/10.1016/0002-9343(89)90123-X

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