By Professor Robert M Graham

Journal articles

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Chen S; Lin F; Xu M; Hwa J; Graham RM, 2000, 'Dominant-negative activity of an α(1β)-adrenergic receptor signal-inactivating point mutation', EMBO Journal, 19, pp. 4265 - 4271

Azurdia RM; Graham RM; Weismann K; Guerin DM; Parslew R, 2000, 'Acne keloidalis in caucasian patients on cyclosporin following organ transplantation [15]', British Journal of Dermatology, 143, pp. 465 - 466, http://dx.doi.org/10.1046/j.1365-2133.2000.03694.x

Corkill JE; Graham R; Hart CA; Stubbs S, 2000, 'Pulsed-field gel electrophoresis of degradation-sensitive DNAs from Clostridium difficile PCR ribotype 1 strains', Journal of Clinical Microbiology, 38, pp. 2791 - 2792, http://dx.doi.org/10.1128/jcm.38.7.2791-2792.2000

O'Rourke MF; Vlachopoulos C; Graham RM, 2000, 'Spurious systolic hypertension in youth', Vascular Medicine, 5, pp. 141 - 145, http://dx.doi.org/10.1177/1358836x0000500303

Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265

Semsarian C; Wu MJ; Ju YK; Marciniec T; Yeoh T; Allen DG; Harvey RP; Graham RM, 1999, 'Skeletal muscle hypertrophy involves a Ca2+/calcineurin/NF-AT2/c-dependent signalling pathway.', CIRCULATION, 100, pp. 354 - 354, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083417101857&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Xu M; Lin F; Lee D; Riek P; Graham RM, 1999, 'Phe310 in transmembrane VI of the α(1B)-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', Journal of Biological Chemistry, 274, pp. 16320 - 16330, http://dx.doi.org/10.1074/jbc.274.23.16320

Semsarian C; Sutrave P; Richmond DR; Graham RM, 1999, 'Insulin-like growth facor (IGF-1) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in skeletal muscle cell model', Biochemical Journal, pp. 443 - 451

Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156

Graham RM; Owens WA, 1999, 'Pathogenesis of inherited forms of dilated cardiomyopathy', New England Journal of Medicine, pp. 1759 - 1762

Chen S; Xu M; Lin F; Lee DJ; Riek RP; Graham RM, 1999, 'Phe310 in Transmembrane VI of the alpha1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', The Journal of Biological Chemistry, pp. 16320 - 16330

Semsarian C; Wu M; Ju Y; Marciniec T; Yeoh T; Allen D; Harvey RJ; Graham RM, 1999, 'Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway', Nature, pp. 576 - 581

Liu X; Hwang H; Cao L; Wen D; Liu N; Graham RM; Zhou M, 1998, 'Release of the neuregulin functional polypeptide requires its cytoplasmic tail', Journal of Biological Chemistry, 273, pp. 34335 - 34340, http://dx.doi.org/10.1074/jbc.273.51.34335

Frank J; McGrath J; Lam H; Graham RM; Hawk JLM; Christiano AM, 1998, 'Homozygous variegate porphyria: Identification of mutations on both alleles of the protoporphyrinogen oxidase gene in a severely affected proband', Journal of Investigative Dermatology, 110, pp. 452 - 455, http://dx.doi.org/10.1046/j.1523-1747.1998.00148.x

Cao LY; Zhang L; Ruiz-Lozano P; Yang Q; Chien KR; Graham RM; Zhou M, 1998, 'A novel putative protein-tyrosine phosphate contains a BRO1-like domain and suppresses Ha-ras-mediated transformation', The Journal of Biological Chemistry, pp. 21077 - 21083

Liu X; Hwang H; Cao LY; Buckland M; Cunningham AL; Chen JG; Chien KR; Graham RM; Zhou M, 1998, 'Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail', Proceedings of the National Academy of Sciences of the United States of America, pp. 13024 - 13029

Grayson TH; Ellis JM; Chen S; Graham RM; Brown RD; Hill CE, 1998, 'Immunohistochemical localisation of alpha1B-adrenergic receptors in the rat iris.', Cell Tissue Res, 293, pp. 435 - 444, http://dx.doi.org/10.1007/s004410051135

Graham RM, 1997, 'More supernumeraries?', British Dental Journal, 183, pp. 49

McGrath JA; Hawk JLM; Graham RM; Christiano AM, 1997, 'Lack of the R59W South African founder effect mutation in protoporphyrinogen oxidase in a British patient with homozygous variegate porphyria [7]', British Journal of Dermatology, 136, pp. 292, http://dx.doi.org/10.1111/j.1365-2133.1997.tb14923.x

Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, 36, pp. 11655 - 11664

Karnik SS; Husain A; Graham RM, 1996, 'Molecular determinants of peptide and non-peptide binding to the AT1 receptor', Clinical and Experimental Pharmacology and Physiology, 23, pp. S58 - S66

Graham RM, 1996, 'An unusual radiograph finding.', British Dental Journal, 180, pp. 448, http://dx.doi.org/10.1038/sj.bdj.4809119

Graham RM; Macleod SP; Hamilton MP, 1996, 'Burning mouth syndrome.', British Dental Journal, 180, pp. 407, http://dx.doi.org/10.1038/sj.bdj.4809101

Perez DM; Hwa J; Gaivin R; Mathur M; Brown F; Graham RM, 1996, 'Constitutive activation of a single effector pathway: Evidence for multiple activation states of a G protein-coupled receptor', Molecular Pharmacology, 49, pp. 112 - 122, http://dx.doi.org/10.1016/s0026-895x(25)08677-8

Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, 'α1-Adrenergic Receptor Subtypes Molecular Structure, Function, and Signaling', Circulation Research, 78, pp. 737 - 749, http://dx.doi.org/10.1161/01.RES.78.5.737

Graham RM; Neubig R; Lynch KR, 1996, 'α2-Adrenoceptors take centre stage at Nashville meeting', Trends in Pharmacological Sciences, 17, pp. 90 - 94, http://dx.doi.org/10.1016/0165-6147(96)30004-7

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, '1-Adrenergic receptor subtypes: molecular structure, function and signalling', Circulation Research, pp. 737 - 749

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, 'alpha(1)-Adrenergic receptor subtypes - Molecular structure, function, and signaling', CIRCULATION RESEARCH, 78, pp. 737 - 749, http://dx.doi.org/10.1161/01.RES.78.5.737

Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, 271, pp. 32385 - 32391

Hwa J; Graham RM; Perez DM, 1996, 'Chimeras of 1-adrenergic receptor subtypes indentify critical residues that modulate active-state isomerization', The Journal of Biological Chemistry, pp. 7956 - 7964

Perez DM; Hwa J; Gaivin R; Mathur M; Brown F; Graham RM, 1996, 'Consitutive activity of a single transduction pathway due to a point-mutation in the 1B-adrenergic receptor', Molecular Pharmacology, pp. 112 - 122

Pollak MR; Delaney VB; Graham RM; Hebert SC, 1996, 'Gitelman`s syndrome (Bartters variant) maps to the thiazide-sensitive cotransporter gene locus on chromosone 16q13 in a large kindred', Journal of the American Society of Nephrology, pp. 2244 - 2248

Hwa J; Graham RM; Perez DM, 1995, 'Identification of critical determinants of α1-adrenergic receptor subtype selective agonist binding', Journal of Biological Chemistry, 270, pp. 23189 - 23195, http://dx.doi.org/10.1074/jbc.270.39.23189

Graham RM, 1995, 'Left handed GDP's and students.', British Dental Journal, 178, pp. 326, http://dx.doi.org/10.1038/sj.bdj.4808754

PEREZ DM; HWA J; GAIVIN R; GRAHAM RM, 1995, 'CONSTITUTIVE ACTIVATION OF A SINGLE EFFECTOR PATHWAY - EVIDENCE FOR INDUCED CONFORMATIONAL PLEIOTROPY OF G-PROTEIN-COUPLED RECEPTORS', FASEB JOURNAL, 9, pp. A849 - A849, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QM40601303&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HWA J; REIK RP; GRAHAM RM; PEREZ DM, 1995, 'EFFECTS OF MUTATING SPECIFIC AMINO-ACIDS ON THE LIGAND-BINDING CHARACTERISTICS OF ALPHA(1)-ADRENERGIC RECEPTOR SUBTYPES', FASEB JOURNAL, 9, pp. A104 - A104, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QL98700609&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Graham RM; Perez DM; Piascik MT; Riek RP; Hwa J, 1995, 'Characterisation of α1-adrenergic receptor subtypes', Pharmacology Communications, 6, pp. 15 - 22

Hasebe N; Hittinger L; Kohin S; Shen YT; Graham RM; Vatner SF, 1995, 'Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs', American Journal of Physiology Heart and Circulatory Physiology, 268, pp. H781 - H787, http://dx.doi.org/10.1152/ajpheart.1995.268.2.h781

Kerr JR; Moore JE; Curran MD; Graham R; Web CH; Lowry KG; Murphy PG; Wilson TS; Ferguson WP, 1995, 'Investigation of a nosocomial outbreak of Pseudomonas aeruginosa pneumonia in an intensive care unit by random amplification of polymorphic DNA assay', Journal of Hospital Infection, 30, pp. 125 - 131, http://dx.doi.org/10.1016/0195-6701(95)90152-3

DeS Senanayake P; Denker J; Bravo EL; Graham RM, 1995, 'Production, characterization, and expression of neuropeptide Y by human pheochromocytoma', Journal of Clinical Investigation, 96, pp. 2503 - 2509, http://dx.doi.org/10.1172/JCI118310

Hwa J; Graham RM; Perez DM, 1995, 'Critical determinants of a -adrenergic receptor subtype-selective ahonist binding', The Journal of Biological Chemistry, pp. 23189 - 23195

Riek RP; Handschumacher MK; Sung S; Tan M; Glynias MJ; Schluchter MD; Novotny J; Graham RM, 1995, 'Evolutionary conservation of both the hydrophilic and hydrophobic nature of transmembrance residues', Journal of Theoretical Biology, 172, pp. 245 - 258

Vincan E; Neylon CB; Graham RM; Woodcock EA, 1995, 'Isolatin of neonatal cardiomyocytes reduces the expression of the GTP-binding protein Gh', Journal of Molecular and Cellular Cardiology, pp. 2393 - 2396

Noda K; Saad YM; Kinoshita A; Graham RM; Boyle T; Husain A; Karnik S, 1995, 'Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms', The Journal of Biological Chemistry, pp. 2284 - 2289

Des Senanayake P; Denker J; Bravo EL; Graham RM, 1995, 'The distribution and release of neuropeptide Y from adrenal and extraadrenal pheochromocytomas', Journal of Clinical Investigation, pp. 2503 - 2509

De Young MB; Kincade-Denker J; Boehm CA; Riek RP; Mamone JA; McSwiggen JA; Graham RM, 1994, 'Functional Characterization of Ribozymes Expressed Using U1 and T7 Vectors for the Intracellular Cleavage of ANF mRNA', Biochemistry, 33, pp. 12127 - 12138, http://dx.doi.org/10.1021/bi00206a016

Casale PN; Fifer MA; Graham RM; Palacios IF, 1994, 'Relation of atrial pressure and plasma level of atrial natriuretic factor in cardiac tamponade', American Journal of Cardiology, 73, pp. 610 - 613, http://dx.doi.org/10.1016/0002-9149(94)90346-8

Noda K; Saad Y; Graham RM; Karnik SS, 1994, 'The high affinity state of the β2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines', Journal of Biological Chemistry, 269, pp. 6743 - 6752, http://dx.doi.org/10.1016/s0021-9258(17)37438-0

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