By Professor Robert M Graham

Journal articles

Du X; Gao X; Kiriazis H; Hannan R; MacCallum P; Graham RM, 2004, 'Cardiac-restricted overexpression of the alpha(1A)-adrenergic receptor preserves contractile function and limits ventricular remodeling after myocardial infarction', Circulation, 110, pp. 300 - 300

Cocks HJ; Kevans P; Graham RM; Brien JE, 2004, 'Evaluation of Therapeutic Drug Monitoring Services and Comparison of Two Models of Service Provision', Journal of Pharmacy Practice and Research, 34, pp. 109 - 113

Du X; Fang L; Gao X; Kiriazis H; Feng X; Hotchkin E; Finch AM; Chaulet H; Graham RM, 2004, 'Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction', Journal of Molecular and Cellular Cardiology, 37, pp. 979 - 987

Li M; Michalicek J; Angus JA; Hunt JE; Dell Italia L; Feneley MP; Graham RM; Husain A, 2004, 'Involvement of chymase-mediated angiotensin II generation in blood pressure regulation', Journal of Clinical Investigation, 114, pp. 112 - 120

Hwang K; Lim S; Kwon H; Bae Y; Kang S; Chung K; Graham RM; Rhee S; Jang Y, 2004, 'Phospholipase C-[delta]1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes', Journal of Steroid Biochemistry and Molecular Biology, 91, pp. 131 - 138, http://www.sciencedirect.com/science/article/B6T8X-4CSYKH2-1/2/ddae75a5eacab1a819c826961b301a29

Kovacic JC; Graham RM, 2004, 'Stem-cell therapy for myocardial diseases', The Lancet, 363, pp. 1735 - 1736, http://www.sciencedirect.com/science/article/B6T1B-4CF51H5-16/2/5af11943dcf04c84ca831fb4b99586df

Ju YK; Wu MJ; Chaulet H; Marciniec T; Graham RM; Allen DG, 2003, 'IGF-1 Enhances a Store-Operated Ca2+ Channel in Skeletal Muscle Myoblasts: Involvement of a CD20-Like Protein', Journal of Cellular Physiology, 197, pp. 53 - 60, http://dx.doi.org/10.1002/jcp.10347

Sharpe IA; Thomas L; Loughnan M; Motin L; Palant E; Croker DE; Alewood D; Chen S; Graham RM; Alewood P; Adams DJ; Lewis RA, 2003, 'Allosteric á1-adrenoceptor antagonism by the conopeptide ñ-TIA', The Journal of Biological Chemistry, 278, pp. 34451 - 34457, http://dx.doi.org/10.1074/jbc.M305410200

Lin F; Owens AW; Kesteven SH; Michalicek J; Chen S; Graham RM; Feneley MP, 2003, 'Cardiac-targeted overexpression of the α1A-AR results in premature death: A potential model of electromechanical dissociation', Heart, Lung and Circulation, 12, pp. A59 - A59, http://dx.doi.org/10.1046/j.1443-9506.2003.02393.x

Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, 92, pp. 1059 - 1061

Johnson K; Van Elten D; Nanda N; Graham RM; Terkeltaub R, 2003, 'Distinct transglutaminase II/TG2-independent and TG2-dependent pathways mediate articular chondrocyte hypertrophy', The Journal of Biological Chemistry, 21, pp. 18824 - 18832

Husain A; Li M; Graham RM, 2003, 'Do studies with ACE N- and C-Fomain-Selective Inhibitors provide evidence for a non-ACE, non-chymase Angiotensin II-forming pathway?', Circ Res, 93, pp. 91 - 93

Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641

Ju Y; Wu M; Chaulet H; Graham RM; Allen DG, 2003, 'IGF-1 enhances store-operated Ca2+ channel activity in skeletal myoblasts : possible involvement of a CD20-like protein', Journal of Cell Physiol, 197, pp. 53 - 60

Rigoutsos I; Riek RP; Graham RM; Novotny J, 2003, 'Structural details (kinks and non-a-helical conformations) in transmembrane helices are intrahelically determined and can be predicted by sequence pattern descriptors.', Nucleic Acids Research, 15, pp. 4625 - 4631

Lorand L; Graham RM, 2003, 'Transglutaminases: crosslinking enzymes with pleiotropic functions.', Nature Reviews Molecular Cell Biology, 4, pp. 140 - 156

Bailey CD; Graham RM; Nanda N; Davies PJ; Johnson GV, 2003, 'Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases', Molecular and Cellular Neuroscience, 25, pp. 493 - 503

Graham R; Wodak AD; Whelan G, 2002, 'New pharmacotherapies for alcohol dependence', Medical Journal of Australia, 177, pp. 103 - 107, http://dx.doi.org/10.5694/j.1326-5377.2002.tb04683.x

Khumalo NP; Loo WJ; Hollowood K; Salvary I; Graham RM; Dawber RPR, 2002, 'Keratosis pilaris atrophicans in mother and daughter', Journal of the European Academy of Dermatology and Venereology, 16, pp. 397 - 400, http://dx.doi.org/10.1046/j.1468-3083.2002.00472.x

Chen S; Lin FF; Xu M; Riek RP; Novotny J; Graham RM, 2002, 'Mutation of a single TMVI residue, Phe282, in the β2-adrenergic receptor results in structurally distinct activated receptor conformations', Biochemistry, 41, pp. 6045 - 6053, http://dx.doi.org/10.1021/bi012189c

Lin F; Chen SH; Cunningham A; Graham RM, 2002, 'Identification of distinct domains reciprocally regulating subtype-specific differences in [alpha](1)-adrenergic receptor phosphorylation and internalisation', FASEB JOURNAL, 16, pp. A564 - A564, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174533603134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Lin F; Xu M; Graham RM, 2002, 'Phe303 in TMVI of the α1B-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation', Biochemistry, 41, pp. 588 - 596, http://dx.doi.org/10.1021/bi011868k

Fatkin D; Graham RM, 2002, 'Molecular mechanisms of inherited cardiomyopathies', Physiological Reviews, 82, pp. 945 - 980, http://dx.doi.org/10.1152/physrev.00012.2002

Graham GG; Graham RM; Day RO, 2002, 'Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)', Current Pharmaceutical Design, 8, pp. 1063 - 1075

Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Identification of Phe303 in transmembrane segment VI of the alpha1B-adrenergic receptor as a key switch residue for isomerization of receptor to multiple conformers', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Mutations of a single TMVI residue, Phe282, in the beta2-adrenergic receptor result in structurally distinct activated receptor-conformations.', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101255&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-α-helical elements modulate polytopic membrane protein architecture', Journal of Molecular Biology, 306, pp. 349 - 362, http://dx.doi.org/10.1006/jmbi.2000.4402

Fatkin D; Graham RM; Spirito P; Maron BJ, 2001, 'Prognostic value of left ventricular hypertrophy in hypertrophic cardiomyopathy', New England Journal of Medicine, 344, pp. 63 - 65, http://dx.doi.org/10.1056/NEJM200101043440115

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-a-helical elements drive diversity of polytopic membrane protein architecture', Journal of Molecular Biology, pp. 349 - 362

Chen S; Lin F; Xu M; Graham RM, 2001, 'Phe303 in transmembrane segment VI of the a1B-adrenergic receptor is a key switchresidue coupling transmembrane helical movements to G protein activation', Biochemistry, pp. 588 - 596

Lin F; Owens WA; Chen S; Stevens ME; Kesteven S; Arthur JF; Woodcock EA; Feneley MP; Graham RM, 2001, 'Targeted a1A-Adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy.', Circ Res, pp. 343 - 350

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Chen S; Lin F; Xu M; Hwa J; Graham RM, 2000, 'Dominant-negative activity of an α(1β)-adrenergic receptor signal-inactivating point mutation', EMBO Journal, 19, pp. 4265 - 4271

Azurdia RM; Graham RM; Weismann K; Guerin DM; Parslew R, 2000, 'Acne keloidalis in caucasian patients on cyclosporin following organ transplantation [15]', British Journal of Dermatology, 143, pp. 465 - 466, http://dx.doi.org/10.1046/j.1365-2133.2000.03694.x

Corkill JE; Graham R; Hart CA; Stubbs S, 2000, 'Pulsed-field gel electrophoresis of degradation-sensitive DNAs from Clostridium difficile PCR ribotype 1 strains', Journal of Clinical Microbiology, 38, pp. 2791 - 2792, http://dx.doi.org/10.1128/jcm.38.7.2791-2792.2000

O'Rourke MF; Vlachopoulos C; Graham RM, 2000, 'Spurious systolic hypertension in youth', Vascular Medicine, 5, pp. 141 - 145, http://dx.doi.org/10.1177/1358836x0000500303

Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265

Semsarian C; Wu MJ; Ju YK; Marciniec T; Yeoh T; Allen DG; Harvey RP; Graham RM, 1999, 'Skeletal muscle hypertrophy involves a Ca2+/calcineurin/NF-AT2/c-dependent signalling pathway.', CIRCULATION, 100, pp. 354 - 354, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083417101857&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Xu M; Lin F; Lee D; Riek P; Graham RM, 1999, 'Phe310 in transmembrane VI of the α(1B)-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', Journal of Biological Chemistry, 274, pp. 16320 - 16330, http://dx.doi.org/10.1074/jbc.274.23.16320

Semsarian C; Sutrave P; Richmond DR; Graham RM, 1999, 'Insulin-like growth facor (IGF-1) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in skeletal muscle cell model', Biochemical Journal, pp. 443 - 451

Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156

Graham RM; Owens WA, 1999, 'Pathogenesis of inherited forms of dilated cardiomyopathy', New England Journal of Medicine, pp. 1759 - 1762

Chen S; Xu M; Lin F; Lee DJ; Riek RP; Graham RM, 1999, 'Phe310 in Transmembrane VI of the alpha1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', The Journal of Biological Chemistry, pp. 16320 - 16330

Semsarian C; Wu M; Ju Y; Marciniec T; Yeoh T; Allen D; Harvey RJ; Graham RM, 1999, 'Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway', Nature, pp. 576 - 581

Liu X; Hwang H; Cao L; Wen D; Liu N; Graham RM; Zhou M, 1998, 'Release of the neuregulin functional polypeptide requires its cytoplasmic tail', Journal of Biological Chemistry, 273, pp. 34335 - 34340, http://dx.doi.org/10.1074/jbc.273.51.34335

Frank J; McGrath J; Lam H; Graham RM; Hawk JLM; Christiano AM, 1998, 'Homozygous variegate porphyria: Identification of mutations on both alleles of the protoporphyrinogen oxidase gene in a severely affected proband', Journal of Investigative Dermatology, 110, pp. 452 - 455, http://dx.doi.org/10.1046/j.1523-1747.1998.00148.x

Cao LY; Zhang L; Ruiz-Lozano P; Yang Q; Chien KR; Graham RM; Zhou M, 1998, 'A novel putative protein-tyrosine phosphate contains a BRO1-like domain and suppresses Ha-ras-mediated transformation', The Journal of Biological Chemistry, pp. 21077 - 21083

Liu X; Hwang H; Cao LY; Buckland M; Cunningham AL; Chen JG; Chien KR; Graham RM; Zhou M, 1998, 'Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail', Proceedings of the National Academy of Sciences of the United States of America, pp. 13024 - 13029

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