By Professor Robert M Graham

Journal articles

Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641

Ju Y; Wu M; Chaulet H; Graham RM; Allen DG, 2003, 'IGF-1 enhances store-operated Ca2+ channel activity in skeletal myoblasts : possible involvement of a CD20-like protein', Journal of Cell Physiol, 197, pp. 53 - 60

Rigoutsos I; Riek RP; Graham RM; Novotny J, 2003, 'Structural details (kinks and non-a-helical conformations) in transmembrane helices are intrahelically determined and can be predicted by sequence pattern descriptors.', Nucleic Acids Research, 15, pp. 4625 - 4631

Lorand L; Graham RM, 2003, 'Transglutaminases: crosslinking enzymes with pleiotropic functions.', Nature Reviews Molecular Cell Biology, 4, pp. 140 - 156

Bailey CD; Graham RM; Nanda N; Davies PJ; Johnson GV, 2003, 'Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases', Molecular and Cellular Neuroscience, 25, pp. 493 - 503

Graham R; Wodak AD; Whelan G, 2002, 'New pharmacotherapies for alcohol dependence', Medical Journal of Australia, 177, pp. 103 - 107, http://dx.doi.org/10.5694/j.1326-5377.2002.tb04683.x

Khumalo NP; Loo WJ; Hollowood K; Salvary I; Graham RM; Dawber RPR, 2002, 'Keratosis pilaris atrophicans in mother and daughter', Journal of the European Academy of Dermatology and Venereology, 16, pp. 397 - 400, http://dx.doi.org/10.1046/j.1468-3083.2002.00472.x

Chen S; Lin FF; Xu M; Riek RP; Novotny J; Graham RM, 2002, 'Mutation of a single TMVI residue, Phe²⁸², in the β2-adrenergic receptor results in structurally distinct activated receptor conformations', Biochemistry, 41, pp. 6045 - 6053, http://dx.doi.org/10.1021/bi012189c

Lin F; Chen SH; Cunningham A; Graham RM, 2002, 'Identification of distinct domains reciprocally regulating subtype-specific differences in [alpha](1)-adrenergic receptor phosphorylation and internalisation', FASEB JOURNAL, 16, pp. A564 - A564, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174533603134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Lin F; Xu M; Graham RM, 2002, 'Phe³⁰³ in TMVI of the α1B-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation', Biochemistry, 41, pp. 588 - 596, http://dx.doi.org/10.1021/bi011868k

Fatkin D; Graham RM, 2002, 'Molecular mechanisms of inherited cardiomyopathies', Physiological Reviews, 82, pp. 945 - 980, http://dx.doi.org/10.1152/physrev.00012.2002

Graham GG; Graham RM; Day RO, 2002, 'Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)', Current Pharmaceutical Design, 8, pp. 1063 - 1075

Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Identification of Phe303 in transmembrane segment VI of the alpha1B-adrenergic receptor as a key switch residue for isomerization of receptor to multiple conformers', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Mutations of a single TMVI residue, Phe282, in the beta2-adrenergic receptor result in structurally distinct activated receptor-conformations.', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101255&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-α-helical elements modulate polytopic membrane protein architecture', Journal of Molecular Biology, 306, pp. 349 - 362, http://dx.doi.org/10.1006/jmbi.2000.4402

Fatkin D; Graham RM; Spirito P; Maron BJ, 2001, 'Prognostic value of left ventricular hypertrophy in hypertrophic cardiomyopathy', New England Journal of Medicine, 344, pp. 63 - 65, http://dx.doi.org/10.1056/NEJM200101043440115

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-a-helical elements drive diversity of polytopic membrane protein architecture', Journal of Molecular Biology, pp. 349 - 362

Chen S; Lin F; Xu M; Graham RM, 2001, 'Phe303 in transmembrane segment VI of the a1B-adrenergic receptor is a key switchresidue coupling transmembrane helical movements to G protein activation', Biochemistry, pp. 588 - 596

Lin F; Owens WA; Chen S; Stevens ME; Kesteven S; Arthur JF; Woodcock EA; Feneley MP; Graham RM, 2001, 'Targeted a1A-Adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy.', Circ Res, pp. 343 - 350

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

Chen S; Lin F; Xu M; Hwa J; Graham RM, 2000, 'Dominant-negative activity of an α(1β)-adrenergic receptor signal-inactivating point mutation', EMBO Journal, 19, pp. 4265 - 4271

Azurdia RM; Graham RM; Weismann K; Guerin DM; Parslew R, 2000, 'Acne keloidalis in caucasian patients on cyclosporin following organ transplantation [15]', British Journal of Dermatology, 143, pp. 465 - 466, http://dx.doi.org/10.1046/j.1365-2133.2000.03694.x

Corkill JE; Graham R; Hart CA; Stubbs S, 2000, 'Pulsed-field gel electrophoresis of degradation-sensitive DNAs from Clostridium difficile PCR ribotype 1 strains', Journal of Clinical Microbiology, 38, pp. 2791 - 2792, http://dx.doi.org/10.1128/jcm.38.7.2791-2792.2000

O'Rourke MF; Vlachopoulos C; Graham RM, 2000, 'Spurious systolic hypertension in youth', Vascular Medicine, 5, pp. 141 - 145, http://dx.doi.org/10.1177/1358836x0000500303

Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265

Semsarian C; Wu MJ; Ju YK; Marciniec T; Yeoh T; Allen DG; Harvey RP; Graham RM, 1999, 'Skeletal muscle hypertrophy involves a Ca2+/calcineurin/NF-AT2/c-dependent signalling pathway.', CIRCULATION, 100, pp. 354 - 354, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000083417101857&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Xu M; Lin F; Lee D; Riek P; Graham RM, 1999, 'Phe³¹⁰ in transmembrane VI of the α(1B)-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', Journal of Biological Chemistry, 274, pp. 16320 - 16330, http://dx.doi.org/10.1074/jbc.274.23.16320

Semsarian C; Sutrave P; Richmond DR; Graham RM, 1999, 'Insulin-like growth facor (IGF-1) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in skeletal muscle cell model', Biochemical Journal, pp. 443 - 451

Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156

Graham RM; Owens WA, 1999, 'Pathogenesis of inherited forms of dilated cardiomyopathy', New England Journal of Medicine, pp. 1759 - 1762

Chen S; Xu M; Lin F; Lee DJ; Riek RP; Graham RM, 1999, 'Phe310 in Transmembrane VI of the alpha1B-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding', The Journal of Biological Chemistry, pp. 16320 - 16330

Semsarian C; Wu M; Ju Y; Marciniec T; Yeoh T; Allen D; Harvey RJ; Graham RM, 1999, 'Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway', Nature, pp. 576 - 581

Liu X; Hwang H; Cao L; Wen D; Liu N; Graham RM; Zhou M, 1998, 'Release of the neuregulin functional polypeptide requires its cytoplasmic tail', Journal of Biological Chemistry, 273, pp. 34335 - 34340, http://dx.doi.org/10.1074/jbc.273.51.34335

Frank J; McGrath J; Lam H; Graham RM; Hawk JLM; Christiano AM, 1998, 'Homozygous variegate porphyria: Identification of mutations on both alleles of the protoporphyrinogen oxidase gene in a severely affected proband', Journal of Investigative Dermatology, 110, pp. 452 - 455, http://dx.doi.org/10.1046/j.1523-1747.1998.00148.x

Cao LY; Zhang L; Ruiz-Lozano P; Yang Q; Chien KR; Graham RM; Zhou M, 1998, 'A novel putative protein-tyrosine phosphate contains a BRO1-like domain and suppresses Ha-ras-mediated transformation', The Journal of Biological Chemistry, pp. 21077 - 21083

Liu X; Hwang H; Cao LY; Buckland M; Cunningham AL; Chen JG; Chien KR; Graham RM; Zhou M, 1998, 'Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail', Proceedings of the National Academy of Sciences of the United States of America, pp. 13024 - 13029

Grayson TH; Ellis JM; Chen SH; Graham RM; Brown RD; Hill CE, 1998, 'Immunohistochemical localisation of alpha(1B)-adrenergic receptors in the rat iris', Cell and Tissue Research, 293, pp. 435 - 444, http://dx.doi.org/10.1007/s004410051135

Graham RM, 1997, 'More supernumeraries?', British dental journal, 183, pp. 49

McGrath JA; Hawk JLM; Graham RM; Christiano AM, 1997, 'Lack of the R59W South African founder effect mutation in protoporphyrinogen oxidase in a British patient with homozygous variegate porphyria [7]', British Journal of Dermatology, 136, pp. 292, http://dx.doi.org/10.1111/j.1365-2133.1997.tb14923.x

Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, 36, pp. 11655 - 11664

Karnik SS; Husain A; Graham RM, 1996, 'Molecular determinants of peptide and non-peptide binding to the AT1 receptor', Clinical and Experimental Pharmacology and Physiology, 23

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, 'alpha(1)-Adrenergic receptor subtypes - Molecular structure, function, and signaling', CIRCULATION RESEARCH, 78, pp. 737 - 749, http://dx.doi.org/10.1161/01.RES.78.5.737

Graham RM, 1996, 'An unusual radiograph finding.', British dental journal, 180, pp. 448, http://dx.doi.org/10.1038/sj.bdj.4809119

Graham RM; Macleod SP; Hamilton MP, 1996, 'Burning mouth syndrome.', British dental journal, 180, pp. 407, http://dx.doi.org/10.1038/sj.bdj.4809101

Perez DM; Hwa J; Gaivin R; Mathur M; Brown F; Graham RM, 1996, 'Constitutive activation of a single effector pathway: Evidence for multiple activation states of a G protein-coupled receptor', Molecular Pharmacology, 49, pp. 112 - 122

Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385

Graham RM; Perez DM; Hwa J; Piascik MT, 1996, 'α1-Adrenergic Receptor Subtypes Molecular Structure, Function, and Signaling', Circulation Research, 78, pp. 737 - 749, http://dx.doi.org/10.1161/01.RES.78.5.737

Graham RM; Neubig R; Lynch KR, 1996, 'α2-Adrenoceptors take centre stage at Nashville meeting', Trends in Pharmacological Sciences, 17, pp. 90 - 94, http://dx.doi.org/10.1016/0165-6147(96)30004-7

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