By Professor Robert M Graham

Journal articles

Chaulet H; Guo J; Owens WA; Michalicek J; Kesteven SH; Guan Z; Prall OW; Mearns BM; Feneley MP; Steinberg S; Graham RM, 2006, 'Sustained augmentation of cardiac alpha(1A)-adrenergic drive results in pathological remodeling with contractile dysfunction, progressive fibrosis and reactivation of matricellular protein genes', Journal of Molecular and Cellular Cardiology, 40, pp. 540 - 552

Finch A; Graham RM, 2006, 'The alpha(1D)-adrenergic receptor: Cinderella or ugly stepsister', Molecular Pharmacology, 69, pp. 1 - 4

Du X; Gao X; Kiriazis H; Moore X; Ming Z; Su Y; Finch A; Hannan R; Dart A; Graham RM, 2006, 'Transgenic alpha(1A)-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival', Cardiovascular Research, 71, pp. 735 - 743

D.F. D; Kovacic JC; Dodds A; Tao H; McDonald P; Feneley MP; Muller DW; Fruend J; Milliken S; Moore J; Itescu S; Graham RM, 2005, 'Granulocyte-Colony Stimulating Factor Decreases Angina and Improves Exercise Capacity in Patients with Chronic Refractory ‘No Option' Ischemic Heart Disease.', Blood, 106, pp. 4215, http://dx.doi.org/10.1182/blood.v106.11.4215.4215

James M; Hoff T; Davis J; Graham R, 2005, 'Grant watch report: Leveraging the power of the media to combat HIV/AIDS: The Kaiser Family Foundation's partnerships with media and others to help educate the public about HIV/AIDS, here and abroad', Health Affairs, 24, pp. 854 - 857, http://dx.doi.org/10.1377/hlthaff.24.3.854

Kovacic JC; Graham RM, 2005, 'Are improvements in cardiac function due to stem cell uptake and engraftment?', American Journal of Cardiology, 95, pp. 159, http://dx.doi.org/10.1016/j.amjcard.2004.07.138

Byrne A; Graham G; Hallinan R; Murnion B; Hulse GK; Arnold-Reed DE; Wodak A; Graham R; Hulse GK, 2005, 'Naltrexone implants as treatment for heroin dependence: Part I (multiple letters)', Addiction Biology, 10, pp. 201, http://dx.doi.org/10.1080/13556210500155789

Begg G; Iismaa S; Carrington L; Holman S; Graham RM; Holman , 2005, 'Allosteric inactivation of transglutaminase 2 by GTP involves stabilisation of a conformational substate and formation of a critical Cys/Tyr H-bond', Biophysical Journal, 88, pp. 15A - 15A

Begg G; Iismaa SE; Carrington L; Holman S; Husain A; Graham RM; Holman , 2005, 'Allosteric regulation of the transamidase activity of transglutaminase 2 by guanine nucleotide', FEBS Journal, 272, pp. 408 - 408

Naqvi N; Liu K; Graham RM; Husain A; Husain A, 2005, 'Evolutionary origins of exopeptidase activity in the C-domain of human angiotensin I-converting enzyme', Federation of American Societies for Experimantal Biology Journal, 19, pp. A293 - A293

Ma DD; Kovacic JC; Dodds AJ; Tao H; Mcdonald PS; Feneley MP; Muller DW; Fruend J; Milliken ST; Moore JJ; Itescu S; Graham RM, 2005, 'Granulocyte-colony stimulating factor decreases angina and improves exercise capacity in patients with chronic refractory `no option` ischemic heart disease', Blood, 106, pp. 134B - 134B

Naqvi N; Liu KH; Graham RM; Husain A, 2005, 'Molecular basis of exopeptidase activity in the C-terminal domain ofhuman angiotensin I-converting enzyme - Insights into the origins ofits exopeptidase activity', The Journal of Biological Chemistry, 280, pp. 6669 - 6675

Wodak AD; Graham RM, 2005, 'Naltrexone implants as treatment for heroin dependence: Part II', Addiction Biology, 10, pp. 202 - 202

Graham RM, 2005, 'Transglutaminases in perspective', Journal of Neurochemistry, 94, pp. 82 - 82

Kovacic JC; Muller DW; Harvey RJ; Graham RM, 2005, 'Update on the use of stem cells for cardiac disease', Internal Medicine Journal, 35, pp. 348 - 356

Palmieri C; Vigushin D; Coombes RC; Kim HS; Kang HJ; Park YB; Kovacic JC; Graham RM, 2004, 'Stem-cell therapy for myocardial diseases [4] (multiple letters)', Lancet, 363, pp. 1734 - 1735, http://dx.doi.org/10.1016/s0140-6736(04)16268-5

Tan JC; McMahon A; Graham RM; Feneley MP, 2004, 'Cardiac myocyte intracellular calcium handling and contractility inalpha1(A)-adrenergic receptor overexpressing', Journal of Molecular and Cellular Cardiology, 37, pp. 301 - 301

Du X; Gao X; Kiriazis H; Hannan R; MacCallum P; Graham RM, 2004, 'Cardiac-restricted overexpression of the alpha(1A)-adrenergic receptor preserves contractile function and limits ventricular remodeling after myocardial infarction', Circulation, 110, pp. 300 - 300

Cocks HJ; Kevans P; Graham RM; Brien JE, 2004, 'Evaluation of Therapeutic Drug Monitoring Services and Comparison of Two Models of Service Provision', Journal of Pharmacy Practice and Research, 34, pp. 109 - 113

Du X; Fang L; Gao X; Kiriazis H; Feng X; Hotchkin E; Finch AM; Chaulet H; Graham RM, 2004, 'Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction', Journal of Molecular and Cellular Cardiology, 37, pp. 979 - 987

Li M; Liu K; Michalicek J; Angus JA; Hunt JE; Dell'Italia LJ; Feneley MP; Graham RM; Husain A, 2004, 'Involvement of chymase-mediated angiotensin II generation in blood pressure regulation.', J Clin Invest, 114, pp. 112 - 120, http://dx.doi.org/10.1172/JCI20805

Hwang K; Lim S; Kwon H; Bae Y; Kang S; Chung K; Graham RM; Rhee S; Jang Y, 2004, 'Phospholipase C-[delta]1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes', Journal of Steroid Biochemistry and Molecular Biology, 91, pp. 131 - 138, http://www.sciencedirect.com/science/article/B6T8X-4CSYKH2-1/2/ddae75a5eacab1a819c826961b301a29

Kovacic JC; Graham RM, 2004, 'Stem-cell therapy for myocardial diseases', The Lancet, 363, pp. 1735 - 1736, http://www.sciencedirect.com/science/article/B6T1B-4CF51H5-16/2/5af11943dcf04c84ca831fb4b99586df

Ju YK; Wu MJ; Chaulet H; Marciniec T; Graham RM; Allen DG, 2003, 'IGF-1 Enhances a Store-Operated Ca2+ Channel in Skeletal Muscle Myoblasts: Involvement of a CD20-Like Protein', Journal of Cellular Physiology, 197, pp. 53 - 60, http://dx.doi.org/10.1002/jcp.10347

Sharpe IA; Thomas L; Loughnan M; Motin L; Palant E; Croker DE; Alewood D; Chen S; Graham RM; Alewood P; Adams DJ; Lewis RA, 2003, 'Allosteric á1-adrenoceptor antagonism by the conopeptide ñ-TIA', The Journal of Biological Chemistry, 278, pp. 34451 - 34457, http://dx.doi.org/10.1074/jbc.M305410200

Lin F; Owens AW; Kesteven SH; Michalicek J; Chen S; Graham RM; Feneley MP, 2003, 'Cardiac-targeted overexpression of the α1A-AR results in premature death: A potential model of electromechanical dissociation', Heart, Lung and Circulation, 12, pp. A59 - A59, http://dx.doi.org/10.1046/j.1443-9506.2003.02393.x

Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, 92, pp. 1059 - 1061

Johnson K; Van Elten D; Nanda N; Graham RM; Terkeltaub R, 2003, 'Distinct transglutaminase II/TG2-independent and TG2-dependent pathways mediate articular chondrocyte hypertrophy', The Journal of Biological Chemistry, 21, pp. 18824 - 18832

Husain A; Li M; Graham RM, 2003, 'Do studies with ACE N- and C-Fomain-Selective Inhibitors provide evidence for a non-ACE, non-chymase Angiotensin II-forming pathway?', Circ Res, 93, pp. 91 - 93

Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641

Ju Y; Wu M; Chaulet H; Graham RM; Allen DG, 2003, 'IGF-1 enhances store-operated Ca2+ channel activity in skeletal myoblasts : possible involvement of a CD20-like protein', Journal of Cell Physiol, 197, pp. 53 - 60

Rigoutsos I; Riek RP; Graham RM; Novotny J, 2003, 'Structural details (kinks and non-a-helical conformations) in transmembrane helices are intrahelically determined and can be predicted by sequence pattern descriptors.', Nucleic Acids Research, 15, pp. 4625 - 4631

Lorand L; Graham RM, 2003, 'Transglutaminases: crosslinking enzymes with pleiotropic functions.', Nature Reviews Molecular Cell Biology, 4, pp. 140 - 156

Bailey CD; Graham RM; Nanda N; Davies PJ; Johnson GV, 2003, 'Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases', Molecular and Cellular Neuroscience, 25, pp. 493 - 503

Graham R; Wodak AD; Whelan G, 2002, 'New pharmacotherapies for alcohol dependence', Medical Journal of Australia, 177, pp. 103 - 107, http://dx.doi.org/10.5694/j.1326-5377.2002.tb04683.x

Khumalo NP; Loo WJ; Hollowood K; Salvary I; Graham RM; Dawber RPR, 2002, 'Keratosis pilaris atrophicans in mother and daughter', Journal of the European Academy of Dermatology and Venereology, 16, pp. 397 - 400, http://dx.doi.org/10.1046/j.1468-3083.2002.00472.x

Chen S; Lin FF; Xu M; Riek RP; Novotny J; Graham RM, 2002, 'Mutation of a single TMVI residue, Phe282, in the β2-adrenergic receptor results in structurally distinct activated receptor conformations', Biochemistry, 41, pp. 6045 - 6053, http://dx.doi.org/10.1021/bi012189c

Lin F; Chen SH; Cunningham A; Graham RM, 2002, 'Identification of distinct domains reciprocally regulating subtype-specific differences in [alpha](1)-adrenergic receptor phosphorylation and internalisation', FASEB JOURNAL, 16, pp. A564 - A564, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174533603134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen S; Lin F; Xu M; Graham RM, 2002, 'Phe303 in TMVI of the α1B-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation', Biochemistry, 41, pp. 588 - 596, http://dx.doi.org/10.1021/bi011868k

Fatkin D; Graham RM, 2002, 'Molecular mechanisms of inherited cardiomyopathies', Physiological Reviews, 82, pp. 945 - 980, http://dx.doi.org/10.1152/physrev.00012.2002

Graham GG; Graham RM; Day RO, 2002, 'Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)', Current Pharmaceutical Design, 8, pp. 1063 - 1075

Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Identification of Phe303 in transmembrane segment VI of the alpha1B-adrenergic receptor as a key switch residue for isomerization of receptor to multiple conformers', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101258&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chen SH; Lin F; Xu M; Graham RM, 2001, 'Mutations of a single TMVI residue, Phe282, in the beta2-adrenergic receptor result in structurally distinct activated receptor-conformations.', FASEB JOURNAL, 15, pp. A220 - A220, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000167438101255&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-α-helical elements modulate polytopic membrane protein architecture', Journal of Molecular Biology, 306, pp. 349 - 362, http://dx.doi.org/10.1006/jmbi.2000.4402

Fatkin D; Graham RM; Spirito P; Maron BJ, 2001, 'Prognostic value of left ventricular hypertrophy in hypertrophic cardiomyopathy', New England Journal of Medicine, 344, pp. 63 - 65, http://dx.doi.org/10.1056/NEJM200101043440115

Riek RP; Rigoutsos I; Novotny J; Graham RM, 2001, 'Non-a-helical elements drive diversity of polytopic membrane protein architecture', Journal of Molecular Biology, pp. 349 - 362

Chen S; Lin F; Xu M; Graham RM, 2001, 'Phe303 in transmembrane segment VI of the a1B-adrenergic receptor is a key switchresidue coupling transmembrane helical movements to G protein activation', Biochemistry, pp. 588 - 596

Lin F; Owens WA; Chen S; Stevens ME; Kesteven S; Arthur JF; Woodcock EA; Feneley MP; Graham RM, 2001, 'Targeted a1A-Adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy.', Circ Res, pp. 343 - 350

Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678

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