By Professor Samuel Norbert Breit

Journal articles

Brown DA; Stephan C; Ward RL; Law MG; Hunter M; Bauskin AR; Amin J; Jung K; Diamandis E; Hampton GM; Russell PJ; Giles GG; Breit SN, 2006, 'Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis', Clinical Cancer Research, 12, pp. 89 - 96

Bauskin AR; Brown DA; Kuffner T; Johnen H; Luo X; Hunter M; Breit SN, 2006, 'Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer', Cancer research, 66, pp. 4983 - 4986

Koopmann J; Rosenzweig C; Zhang ZP; Canto M; Brown DA; Hunter M; Yeo CB; Chan DJ; Breit SN; Goggins M; Hunter M, 2006, 'Serum markers in patients with resectable pancreatic adenocarcinoma: Macrophage inhibitory cytokine 1 versus CA19-9', Clinical Cancer Research, 12, pp. 442 - 446

Stephan C; Xu C; Brown DA; Breit SN; Michael AW; Nakamura T; Diamandis E; Meyer H; Cammann H; Jung K, 2006, 'Three new serum markers for prostate cancer detection within a percent free PSA-based artificial neural network', Prostate, 66, pp. 651 - 659

Littler DR; Assaad NN; Harrop SJ; Brown LJ; Pankhurst G; Luciani P; Aguilar M; Mazzanti M; Berryman M; Breit SN; Curmi PM, 2005, 'Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4', FEBS Journal, 272, pp. 4996 - 5007

Saeki K; Yasugi E; Okuma E; Breit SN; Nakamura M; Toda T; Kaburagi Y; Yuo A, 2005, 'Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin', American Journal of Physiology - Endocrinology and Metabolism, 289, pp. 419 - 428

Liu T, 2005, 'The propeptide mediates formation of stromal stores of ProMIC-1: role in determining prostate cancer outcome', Cancer Research, 65, pp. 2330 - 2336, http://dx.doi.org/10.1158/0008-5472.CAN-04-3827

Weber F; Byrne S; Le S; Brown DA; Breit SN; Scolyer R; Halliday GM, 2005, 'Transforming growth factor-beta(1) immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system', Cancer Immunology and Immunotherapy, 54, pp. 898 - 906

Marjono B; Manuelpillai U; Dimitriadis E; Salamonsen L; Breit S; Wallace E, 2004, '270.Macrophage inhibitory cytokine-1 at the maternal - fetal interface in early pregnancy', Reproduction, Fertility and Development, 16, pp. 270 - 270, http://dx.doi.org/10.1071/srb04abs270

Wallace EM; Marjono B; Brown DA; Crossley J; Aitken DK; Tong S; Breit SN, 2004, 'Maternal serum and amniotic fluid levels of macrophage inhibitorycytokine 1 in Down syndrome and chromosomally normal pregnancies', Prenatal Diagnosis, 24, pp. 224 - 226

Tong S; Marjono B; Brown DA; Mulvey S; Breit SN; Manuelpillai U; Wallace EM, 2004, 'Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as apredictor of miscarriage', Lancet, 363, pp. 129 - 130

Koopmann J; Buckhaults P; Brown DA; Zahurak M; Sato N; Fukushima N; Sokoll L; Chan DW; Yeo C; Hruban R; Breit SN; Kinzler KW; Vogelstein B; Goggins M, 2004, 'Serum macrophage inhibitory cytokine 1 as a marker of pancreatic andother periampullary cancers', Clinical Cancer Research, 10, pp. 2386 - 2392

Littler DR; Fairlie WD; Brown LJ; Pankhurst G; Pankhurst SM; Demaere MZ; Campbell TJ; Bauskin AR; Tonini R; Mazzanti M; Breit SN; Curmi PM; Harrop SJ, 2004, 'The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition', The Journal of Biological Chemistry, 279, pp. 9298 - 9305

Singarayar SB; Bursill JA; Wyse KR; Bauskin AR; Wu WM; Vandenberg JI; Breit SN; Campbell TJ, 2003, 'Extracellular acidosis modulates drug block of Kv4.3 currents by flecainide and quinidine', Journal of Cardiovascular Electrophysiology, 14, pp. 641 - 650

Liu T, 2003, 'Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum', Proceedings of the National Academy of Sciences of the United States of America, 100, pp. 3410 - 3415, http://dx.doi.org/10.1073/pnas.0530278100

Liu T; Bauskin AR; Zaunders J; Brown DA; Pankhurst S; Russell PJ; Breit SN, 2003, 'Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells', Cancer research, 63, pp. 5034 - 5040

Marjono AB; Brown DA; Horton KE; Wallace EM; Breit SN; Manuelpillai U, 2003, 'Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy', Placenta, 24, pp. 100 - 106

Yang H; Filipovic Z; Brown DA; Breit SN; Vassilev LT, 2003, 'Macrophage inhibitory cytokine-1: a novel biomarker for p53 pathway activation', Molecular Cancer Therapeutics, 2, pp. 1023 - 1029

Keelan JA; Wang K; Chaiworapongsa T; Romero R; Mitchell MD; Sato TA; Brown DA; Fairlie WD; Breit SN, 2003, 'Macrophase hihibitory cytokine 1 (MIC-1) in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes', Molecular Human Reproduction, 9, pp. 535 - 540

Brown DA; Ward RL; Buckhaults P; Liu T; Romans KE; Hawkins NJ; Bauskin AR; Kinzler KW; Vogelstein B; Breit SN, 2003, 'MIC 1 serum level and genotype: Associations with progress and prognosis of colorectal carcinoma', Clinical Cancer Research, 9, pp. 2642 - 2650

Torres M; Bansal PS; Sunde M; Clarke CE; Bursill JA; Smith DG; Bauskin AR; Breit SN; Campbell TJ; Alewood P; Kuchel PW; Vandenberg JI, 2003, 'Structure of the HERGK+ channel S5P extracellulal linker: Role of an amphipathic a-helix in C-type inactivation.', Journal of Biochemistry, 278, pp. 42136 - 42148

Albertoni M; Shaw PH; Nozaki M; Sophie G; Tenan M; Hamou MF; Fairlie DW; Breit SN; Paralkar VM; De Tribolet N; Van Meir EG; Hegi ME, 2002, 'Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1', Oncogene, 21, pp. 4212 - 4219, http://dx.doi.org/10.1038/sj.onc.1205610

Qiu MR; Campbell TJ; Breit SN, 2002, 'Erratum: A potassium ion channel is involved in cytokine production by activated human macrophages (Clinical and Experimental Immunology (2002) 130 (67-74))', Clinical and Experimental Immunology, 130, pp. 559 - 561, http://dx.doi.org/10.1046/j.1365-2249.2002.02041.x

Parson D; Schlieder B; Beatty P, 2002, 'Extension language automation of embedded system debugging', Automated Software Engineering, 9, pp. 7 - 39, http://dx.doi.org/10.1023/A:1013276002164

Qiu MR; Campbell TJ; Breit SN, 2002, 'A potassium ion channel is involved in cytokine production by activated human macrophages', Clinical and Experimental Immunology, 130, pp. 67 - 74

Min D; Moore AG; Breit SN; Bain MA; Lyons JG, 2002, 'Activation of Macrophage Promatrix metalloproteinase-9 by Lipopolysaccharide-Associated Proteinases', Journal of Immunology, 168, pp. 2449 - 2455

Liu T, 2002, 'Antibody-based approach to high-volume genotyping for MIC-1 polymorphism', BioTechniques, 33, pp. 118 - 120

Liu T, 2002, 'Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study', Lancet, 359, pp. 2159 - 2163, http://dx.doi.org/10.1016/S0140-6736(02)09093-1

Singarayar SB; Singleton CB; Tie H; Wyse KR; Bursill JA; Bauskin AR; Wu WM; Valenzuela SM; Breit SN; Campbell TJ, 2002, 'Effects of components of ischemia on the Kv4.3 current stably expressed in chinese hamster ovary cells', Journal of Mol Cell Caridiol, 34, pp. 197 - 207

Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PM; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese Hamster Ovary cells expressing CLIC1', The Journal of Biological Chemistry, 277, pp. 26003 - 26011

Tie H; Walker BD; Singleton CB; Bursill JA; Wyse KR; Campbell TJ; Valenzuela SM; Breit SN, 2001, 'Clozapine and sudden death [10]', Journal of Clinical Psychopharmacology, 21, pp. 630 - 632, http://dx.doi.org/10.1097/00004714-200112000-00023

Christofi FL; Zhang H; Yu JG; Guzman J; Xue J; Kim M; Wang YZ; Cooke HJ, 2001, 'Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system', Journal of Comparative Neurology, 439, pp. 46 - 64, http://dx.doi.org/10.1002/cne.1334

Harrop SJ; Demaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A resolution', The Journal of Biological Chemistry, pp. 44993 - 45000

Fairlie WD; Russell PK; Wu WM; Moore AG; Zhang H; Brown PK; Bauskin AR; Breit SN, 2001, 'Epitope mapping of the transforming growth factor-beta superfamily protein macrophage inhibitory cytokine-1 (MIC-1): indentification of at least five distinct epitope specificities', Biochemistry, pp. 65 - 73

Schober A; Bottner M; Strelau J; Kinscherf R; Bonaterra GA; Barth M; Schilling L; Fairlie WD; Breit SN; Unisicker K, 2001, 'Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (CDF-15/MIC-1) in the perinatal adult and injured rat brain', Journal of Comparative Neurology, pp. 32 - 45

Fairlie WD; Zhang H; Wu WM; Pankhurst S; Bauskin AR; Russell PK; Brown PK; Breit SN, 2001, 'The propeptide of the transforming growth factor beta superfamily member macrophage inhibitory cytokine-1 (MIC-1) Is a multifunctional domain that can facilitate protein folding and secretion', The Journal of Biological Chemistry, pp. 16911 - 16918

Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Warton K; Musgrove EA; Campbell TJ; Breit SN, 2000, 'The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle', Journal of Physiology, 529, pp. 541 - 552, http://dx.doi.org/10.1111/j.1469-7793.2000.00541.x

Gilmour TK; Wilkinson B; Breit SN; Kossard S, 2000, 'Analysis of dendritic cell populations using a revised histological staging of morphoea', British Journal of Dermatology, 143, pp. 1183 - 1192, http://dx.doi.org/10.1046/j.1365-2133.2000.03886.x

Moore AG; Brown DA; Fairlie WD; Bauskin AR; Brown PK; Munier MLC; Russell PK; Salamonsen LA; Wallace EM; Breit SN, 2000, 'The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women', Journal of Clinical Endocrinology and Metabolism, 85, pp. 4781 - 4788, http://dx.doi.org/10.1210/jc.85.12.4781

Warton K; Valenzuela S; Tonini R; Mazzanti M; Breit S, 2000, 'Intracellular Ion Channel NCC27 Moves between a Soluble and a Transmembrane State', Biochemical Society Transactions, 28, pp. A471 - A471, http://dx.doi.org/10.1042/bst028a471c

Fairlie WD; Zhang HP; Brown PK; Russell PK; Bauskin AR; Breit SN, 2000, 'Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris', Gene, 254, pp. 67 - 76, http://dx.doi.org/10.1016/S0378-1119(00)00295-X

Tie H; Walker BD; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'The heart of psychotropic drug therapy.', Lancet, 355, pp. 1825, http://dx.doi.org/10.1016/S0140-6736(05)73083-X

Walker BD; Singleton CB; Tie H; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell LV, 2000, 'Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel', Cardiovascular Research, pp. 44 - 58

Tonini R; Ferroni A; Valenzuela SM; Warton K; Campbell TJ; Breit SN; Mazzanti M, 2000, 'Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells', Federation of American Societies for Experimantal Biology Journal, 14, pp. 1171 - 1178

Walker BD; Tie H; Singleton CB; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'Hyperkalaemia and acidosis modify HERG channel biophysical properties and antagonise inhibition by sotalol', Heart, Lung and Circulation, 9, pp. A131 - A131, http://dx.doi.org/10.1046/j.1443-9506.2000.07650.x

Tie H; Walker BD; Singleton CB; Valenzuela SM; Bursill JA; Wyse KR; Breit SN; Campbell TJ, 2000, 'Inhibiton of HERG potassium channels by the antimalarial agent halofantrine', British Journal of Pharmacology, 130, pp. 1967 - 1975

Singleton CB; Walker BD; Tie H; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell TJ, 2000, 'Potent blockade by quinidine of the Kv4.3 current: Significance with regard to treatment of the brugada syndrome', Heart, Lung and Circulation, 9, pp. A92 - A92, http://dx.doi.org/10.1046/j.1443-9506.2000.06115.x

Tie H; Walker BD; Singleton CB; Bursill J; Wyse K; Valenzuela S; Breit SN; Campbell TJ, 2000, 'The antipsychotic agents thioridazine, chlorpromazine and clozapine block the human-ether-a-go-go-related gene (HERG) potassium channel: Cellular mechanism for proarrhythmia', Heart, Lung and Circulation, 9, pp. A109 - A109, http://dx.doi.org/10.1046/j.1443-9506.2000.06796.x

Bauskin AR; Zhang H; Fairlie WD; He XY; Russell PJ; Moore A; Brown DM; Stanley K; Breit SN, 2000, 'The Propeptide of macrophage inhibitory cytokine (MIC-1) , a TGF-b superfamily member, act as a quality control determinant for correctly folded MIC-1.', European Molecular Biology Organization, 19, pp. 2212 - 2220

Breit S; Kolb HA; Häussinger D; Lang F, 1999, 'Effects of tetrabutylhydroperoxide on hepatocyte ion channels', Cellular Physiology and Biochemistry, 9, pp. 133 - 138, http://dx.doi.org/10.1159/000016310

Back to profile page