By Professor Samuel Norbert Breit

Journal articles

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA; Hassanpour Golakani M, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144

Jiang L; Phang JM; Yu J; Harrop SJ; Sokolova AV; Duff AP; Wilk KE; Alkhamici H; Breit SN; Valenzuela SM; Brown LJ; Curmi PMG, 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, 1838, pp. 643 - 657, http://dx.doi.org/10.1016/j.bbamem.2013.05.025

Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown DA, 2014, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – The Sydney Memory and Aging Study', Neurology, Psychiatry and Brain Research, 20, pp. 9 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.145

Averaimo S; Abeti R; Savalli N; Brown LJ; Curmi PMG; Breit SN; Mazzanti M, 2013, 'Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties', PLoS ONE, 8, pp. e74523, http://dx.doi.org/10.1371/journal.pone.0074523

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown D, 2013, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study', Aging Cell, 12, pp. 882 - 889, http://dx.doi.org/10.1111/acel.12116

Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', Journal of Clinical Oncology, 31, pp. e22175 - e22175, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22175

Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA; Hassanpour Golakani M, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547

Tsai VW-W; Macia L; Johnen H; Kuffner T; Manadhar R; Jorgensen ; Lee-Ng KKM; Hong PZ; Wu L; Marquis C; Jiang L; Husaini Y; Lin S; Herzog H; Brown DA; Sainsbury-Salis A; Breit SN; Zhang H, 2013, 'TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator', PLoS ONE, 8, pp. e55174, http://dx.doi.org/10.1371/journal.pone.0055174

Tsai VW-W; Husaini Y; Manandhar R; Lee-ng KKM; Hong PZ; Harriott K; Jiang L; Lin S; Sainsbury-Salis A; Brown DA; Breit SN, 2012, 'Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, 3, pp. 239 - 243, http://dx.doi.org/10.1007/s13539-012-0082-6

Johnen H; Kuffner T; Brown DA; Wu L; Stocker R; Breit SN; Wu B; Southwell Keely P, 2012, 'Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE(-/-) mice from the development of atherosclerosis', Cardiovascular Pathology, 21, pp. 499 - 505, http://dx.doi.org/10.1016/j.carpath.2012.02.003

Jiang L; Salao K; Li H; Rybicka JM; Yates R; Luo X; Shi XX; Kuffner T; Tsai VW-W; Husaini Y; Wu L; Brown DA; Grewal T; Brown LJ; Curmi PM; Breit SN, 2012, 'Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification', Journal of Cell Science, 125, pp. 5479 - 5488, http://dx.doi.org/10.1242/jcs.110072

Macia L; Tsai VWW; Nguyen AD; Johnen H; Kuffner T; Shi Y; Lin S; Herzog H; Brown DA; Breit SN; Sainsbury-Salis A, 2012, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets', PLoS One, 7, pp. e34868, http://dx.doi.org/10.1371/journal.pone.0034868

Breit SN; Carrero JJ; Tsai VWW; Yagoutifam N; Luo XW; Kuffner T; Bauskin AR; Wu L; Jiang L; Baranyi P; Heimburer O; Murikami M; Apple F; Marquis C; Macia L; Lin S; Sainsbury-Salis A; Herzog H; Law MG; Stenvinkel P; Brown DA; Han A, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575

Husaini Y; Qiu MR; Lockwood G; Luo X; Shang P; Kuffner T; Tsai VW-W; Lele J; Russell PJ; Brown DA; Breit SN; Jiang L; Qiu M-R, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice', PLoS One, 7, pp. e43833, http://dx.doi.org/10.1371/journal.pone.0043833

Brown D; Hance KW; Rogers C; Sansbury ; Albert P; Murphy G; Laiyemo A; Wang Z; Cross A; Schatzkin A; Danta M; Srasu ; Amin J; Law MG; Breit SN; Lanza E; Brown , 2012, 'Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?', Cancer Epidemiology Biomarkers and Prevention, 21, pp. 337 - 346, http://dx.doi.org/10.1158/1055-9965.EPI-11-0786

Brown DA; Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, 17, pp. S344 - S344, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mahon KL; Chatfield MD; Lee-Ng M; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Sutherland RL; Horvath L, 2011, 'Cytokines' profiles to predict chemotherapy outcome in castration-resistant prostate cancer (CRPC).', JOURNAL OF CLINICAL ONCOLOGY, 29, http://dx.doi.org/10.1200/jco.2011.29.15_suppl.4598

Tsai VWW; Mohammad MG; Tolhurst O; Breit SN; Sawchenko P; Brown DA, 2011, 'CCAAT/enhancer binding protein-CEBPD, expression by dendritic cells regulates CNS autoimmune inflammatory disease', The Journal of Neuroscience, 31, pp. 17612 - 17621, http://dx.doi.org/10.1523/?JNEUROSCI.3449-11.2011

Mynott A; Harrop SJ; Brown LJ; Breit SN; Kobe B; Curmi PM, 2011, 'Crystal structure of importin-$B&AB bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4', FEBS Journal, 278, pp. 1662 - 1675, http://www.ncbi.nlm.nih.gov/pubmed/21388519

Breit SN; Johnen H; Cook AD; Tsai VWW; Mohammad MG; Tamara K; Hong PZ; Marquis C; Lele J; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137

Goodchild SC; Angstmann CN; Breit SN; Curmi PM; Brown LJ, 2011, 'Transmembrane extension and oligomerization of the CLIC1 chloride intracellular channel protein upon membrane interaction', Biochemistry, 50, pp. 10887 - 10897, http://dx.doi.org/10.1021/bi2012564

Goodchild SC; Howell MW; Littler DR; Mandyam RA; Sale KL; Mazzanti M; Breit SN; Curmi PMG; Brown LJ, 2010, 'Metamorphic response of the CLIC1 chloride intracellular ion channel protein upon membrane interaction', Biochemistry, 49, pp. 5278 - 5289, http://dx.doi.org/10.1021/bi100111c

Qiu MR; Jiang L; Matthaei KI; Schoenwaelder SM; Kuffner T; Mangin P; Joseph JE; Low J; Connor D; Valenzuela SM; Curmi PMG; Brown LJ; Mahaut-Smith M; Jackson SP; Breit SN, 2010, 'Erratum: Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene', Genesis, 48, pp. 351 - 351, http://dx.doi.org/10.1002/dvg.20616

Roth P; Junker M; Tritschler I; Mittelbronn M; Dombrowski Y; Breit SN; Tabatabai G; Wick W; Weller M; Wischhusen J, 2010, 'GDF-15 contributes to proliferation and immune escape of malignant gliomas', Clinical Cancer Research, 16, pp. 3559 - 3851

Qiu MR; Jiang L; Matthaei KI; Schoenwaelder S; Kuffner T; Mangin P; Joseph JE; Low J; Connor DE; Valenzuela SM; Curmi P; Brown LJ; Mahaut-Smith MP; Jackson S; Breit SN, 2010, 'Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene', Genesis, 48, pp. 127 - 136

Wiklund F; Bennet AM; Magnusson PKE; Eriksson UK; Lindmark F; Wu L; Yaghoutyfam N; Marquis C; Stattin P; Pedersen NL; Adami H; Gronberg H; Breit SN; Brown DA, 2010, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality', Aging Cell, 9, pp. 1057 - 1064, http://dx.doi.org/10.1111/j.1474-9726.2010.00629.x

Skipworth R; Deans DAC; Tan BHL; Sangster K; Paterson-Brown S; Brown DA; Hunter M; Breit SN; Ross JA; Fearson KCH; Hunter M, 2010, 'Plasma MIC-1 corelates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer', British Journal of Cancer, 102, pp. 665 - 672

Littler DR; Harrop SJ; Goodchild SC; Phang J; Mynott AV; Jiang L; Valenzuela SM; Mazzanti M; Brown LJ; Breit SN; Curmi PM, 2010, 'The enigma of the CLIC proteins: Ion channels,redox proteins,enzymes,scaffolding proteins?', FEBS Letters, 584, pp. 2093 - 2101

Bauskin AR; Jiang L; Luo X; Brown DA; Breit SN, 2010, 'The TGF-b superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores', Journal of Interferon and Cytokine Research, 30, pp. 389 - 397

Shnaper S; Desbaillets I; Brown DA; Murat A; Migliavacca E; Schluep M; Ostermann S; Hamou MF; Stupp R; Breit SN; De Tribolet N; Hegi ME, 2009, 'Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome', International Journal of Cancer, 125, pp. 2624 - 2630, http://dx.doi.org/10.1002/ijc.24639

Brown DA; Lindmark F; Stattin P; Bälter K; Adami HO; Zheng SL; Xu J; Isaacs WB; Grönberg H; Breit SN; Wiklund FE, 2009, 'Macrophage inhibitory cytokine 1: A new prognostic marker in prostate cancer', Clinical Cancer Research, 15, pp. 6658 - 6664, http://dx.doi.org/10.1158/1078-0432.CCR-08-3126

Horvath L; Zhao L; Lee B; Brown D; Molloy M; Marx G; Boyer M; Breit S; Sutherland R; Henshall S, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel in hormone-refractory prostate cancer by proteomic profiling.', J Clin Oncol, 27, pp. 11010, http://www.ncbi.nlm.nih.gov/pubmed/27963974

Wakchoure S; Swain T; Hentunen T; Bauskin AR; Brown DA; Breit SN; Vuopala K; Harris K; Selander K, 2009, 'Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss', Prostate, 69, pp. 652 - 661

Zaunders J; Munier ML; Seddiki N; Pett SL; Ip S; Bailey M; Xu Y; Brown KJ; Dyer W; Kim MS; De Rose R; Kent SJ; Jiang L; Breit SN; Emery S; Cunningham AL; Cooper DA; Kelleher AD, 2009, 'High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40)', Journal of Immunology, 183, pp. 2827 - 2836, http://dx.doi.org/10.4049/jimmunol.0803548

Zhao L; Lee BY; Brown DA; Molloy M; Marx GM; Pavlakis N; Boyer MJ; Stockler M; Kaplan W; Breit SN; Sutherland RL; Henshall SM; Horvath LG, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling', Cancer research, 69, pp. 7696 - 7703

Boyle G; Pedley J; Martyn A; Banducci K; Strutton G; Brown DA; Breit SN; Parsons PG, 2009, 'Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity', Journal of Investigative Dermatology, 129, pp. 383 - 391

Goodchild SC; Howell M; Cordina NM; Littler DR; Breit SN; Curmi PM; Brown LJ, 2009, 'Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane', European Biophysics Journal With Biophysics Letters, 39, pp. 129 - 138, http://dx.doi.org/10.1007/s00249-009-0450-0

Littler D; Brown LJ; Breit SN; Perrakis A; Curmi PM, 2009, 'Structure of human CLIC3 at 2 A resolution', Proteins - Structure Function and Bioinformatics, 78, pp. 1594 - 1600, http://dx.doi.org/10.1002/prot.22675

Paradisi S; Matteucci A; Fabrizi C; Denti M; Abeti R; Breit SN; Malchiodi-Albedi F; Mazzanti M, 2008, 'Blockade of chloride intracellular ion channel 1 stimulates a beta phagocytosis', Journal of Neuroscience Research, 86, pp. 2488 - 2498

Milton RH; Abeti R; Averaimo S; De Biasi S; Vitellaro L; Jiang L; Curmi PM; Breit SN; Duchen MR; Mazzanti M, 2008, 'CLIC1 function is required for B-amyloid-induced generation of reactive oxygen species by microglia', Journal of Neuroscience, 28, pp. 11488 - 11499

Littler DR; Luciani P; Pankhurst G; Mandyam R; Mazzanti M; Tanda S; Berryman M; Breit SN; Curmi PM; Brown LJ; Mynott AV; Harrop SJ, 2008, 'Comparison of vertebrate and invertebrate CLIC proteins: The crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC', Proteins - Structure Function and Bioinformatics, 71, pp. 364 - 378, http://dx.doi.org/10.1002/prot.21704

Selander KS; Brown DA; Sequeiros GB; Hunter M; Desmond R; Parpala T; Risteli J; Breit SN; Jukkola-Vuorinen A, 2007, 'Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases', Cancer Epidemiology Biomarkers and Prevention, 16, pp. 532 - 537, http://dx.doi.org/10.1158/1055-9965.EPI-06-0841

Brown DA; Moore JJ; Johnen H; Smeets TJ; Bauskin AR; Kuffner T; Weedon H; Milliken ST; Tak PP; Smith MD; Breit SN, 2007, 'Serum macrophage inhibitory cytokine 1 in rheumatoid arthritis - A potential marker of erosive joint destruction', Arthritis Care & Research, 56, pp. 753 - 764

Cromer B; Gorman M; Hansen G; Adams J; Coggan M; Littler DR; Brown LJ; Mazzanti M; Breit SN; Curmi PM; Dulhunty A; Board P; Parker M, 2007, 'Structure of the Janus protein human CLIC2', Journal of Molecular Biology, 374, pp. 719 - 731

Johnen H; Lin S; Kuffner T; Brown DA; Tsai V; Bauskin AR; Wu L; Pankhurst G; Jiang L; Junankar S; Hunter M; Fairlie WD; Lee NJ; Enriquez R; Baldock P; Corey E; Apple F; Murakami M; Lin E; Wang CC; During M; Sainsbury A; Herzog H; Breit SN, 2007, 'Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1', Nature Medicine, 13, pp. 1333 - 1340

Agarwal MK; Hastak K; Jackson MW; Breit SN; Stark GR; Agarwal ML, 2006, 'Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 16278 - 16283, http://dx.doi.org/10.1073/pnas.0607210103

Rasiah KK; Kench JG; Gardiner-Garden M; Biankin AV; Golovsky D; Brenner PC; Kooner R; O Neill G; Turner J; Delprado W; Lee CS; Brown DA; Breit SN; Grygiel JJ; Horvath LG; Stricker PD; Sutherland RL; Henshall SM, 2006, 'Aberrant neuropepticle Y and macrophage inhibitory cytokine-1 expression are early events in prostate cancer development and are associated with poor prognosis', Cancer epidemiology biomarkers and prevention, 15, pp. 711 - 716

Xu J; Kimball T; Lorenz J; Brown DA; Bauskin AR; Klevitsky R; Hewett T; Breit SN; Molkentin J, 2006, 'GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation', Circulation Research, 98, pp. 342 - 350

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