By Dr Jason Ciril Kovacic

Conference Abstracts

Namasivayam M; Meredith T; Muller DWM; Roy DA; Roy AK; Kovacic JC; Hayward CS; Feneley MP, 2023, 'MACHINE LEARNING PREDICTION OF PROGRESSIVE SUBCLINICAL MYOCARDIAL DYSFUNCTION IN MODERATE AORTIC STENOSIS', in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER SCIENCE INC, LA, New Orleans, Vol. 81, pp. 1398 - 1398, presented at 72nd Annual Scientific Session (ACC), LA, New Orleans, 04 March 2023 - 06 March 2023

Shah NA; Choi H; Khan S; Kovacic J; Kim-Schulze S; Mani V; Suarez-Farinas M, 2021, 'Nasal Inflammatory Proteomics Before and After Obstructive Sleep Apnea (OSA) Treatment', in American Journal of Respiratory and Critical Care Medicine, Oxford University Press (OUP), Vol. 203, pp. a4718 - a4718, presented at TP132. TP132 EPIDEMIOLOGY AND GENETICS OF SLEEP DISORDERS: EXAMINE THE LATEST ADVANCES!, http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4718

Georges A; Albuisson J; Berrandou T; Dupré D; Lorthioir A; Amar L; Januszewicz A; Motreff P; Adlam D; Azizi M; Gornik H; Ganesh S; Kovacic J; Jeunemaitre X; Bouatia-Naji N, 2021, 'RARE LOSS-OF-FUNCTION MUTATIONS OF PTGIR IDENTIFIED IN FIBROMUSCULAR DYSPLASIA AND SPONTANEOUS CORONARY ARTERY DISSECTION', in Journal of Hypertension, Wolters Kluwer, Vol. 39, pp. e262 - e263, http://dx.doi.org/10.1097/01.hjh.0000747460.58287.84

McGrath-Cadell L; Hesselson S; Tarr I; Iismaa SE; Bax M; Junday K; Dunwoodie SE; Fatkin D; Kovacic J; Muller DWM; Giannoulatou E; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a family history of aortic artery dissection, a case series', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Vol. 42, pp. 2787 - 2787

Shah NA; Choi H; Khan S; Kovacic J; Kim-Schulze S; Mani V; Suarez-Farinas M, 2021, 'Targeted Plasma Inflammatory Proteomics Before and After Obstructive Sleep Apnea (OSA) Treatment', in American Journal of Respiratory and Critical Care Medicine, Oxford University Press (OUP), Vol. 203, pp. a4714 - a4714, presented at TP132. TP132 EPIDEMIOLOGY AND GENETICS OF SLEEP DISORDERS: EXAMINE THE LATEST ADVANCES!, http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4714

Cao D; Mehran R; Dangas GD; Chandiramani R; Sartori S; Roumeliotis A; Goel R; Nicolas J; Baber U; Stefanini GG; Kovacic J; Sweeny J; Krishnan P; Barman N; Sharma SK; Kini AS, 2020, 'FEASIBILITY, SAFETY AND OUTCOMES OF ORBITAL ATHERECTOMY FOR CORONARY IN-STENT RESTENOSIS: ACUTE PROCEDURAL AND LONG-TERM OUTCOMES', in Journal of the American College of Cardiology, Elsevier, Vol. 75, pp. 1505, http://dx.doi.org/10.1016/s0735-1097(20)32132-x

Chandiramani R; Mehran R; Cao D; Goel R; Roumeliotis A; Nicolas J; Blum M; Sartori S; Chen H; Bedekar R; Kesanakurthy S; Kovacic J; Sweeny J; Krishnan P; Barman N; Baber U; Dangas GD; Sharma SK; Kini AS, 2020, 'HIGH BLEEDING RISK AFTER PERCUTANEOUS CORONARY INTERVENTION: IMPACT OF RACE/ETHNICITY', in Journal of the American College of Cardiology, Elsevier, Vol. 75, pp. 1157, http://dx.doi.org/10.1016/s0735-1097(20)31784-8

Cao D; Mehran R; Chandiramani R; Sartori S; Dangas GD; Nicolas J; Goel R; Roumeliotis A; Baber U; Stefanini GG; Kovacic J; Sweeny J; Krishnan P; Barman N; Sharma SK; Kini AS, 2020, 'PERFORMANCE OF THE ACADEMIC RESEARCH CONSORTIUM FOR HIGH BLEEDING RISK CRITERIA ACCORDING TO SEX', in Journal of the American College of Cardiology, Elsevier, Vol. 75, pp. 1414, http://dx.doi.org/10.1016/s0735-1097(20)32041-6

Yu J, 2013, 'Impact of vascular closure with the pre-closure technique on adverse events in patients undergoing transfemoral balloon aortic valvuloplasty: Results from a 2-centre registry', in Journal of the American College of Cardiology, Elsevier Science Inc, Vol. 59, pp. e234 - e234

Yu J, 2012, 'IMPACT OF BIVALIRUDIN ON ACCESS AND NON-ACCESS RELATED BLEEDING IN PATIENTS UNDERGOING BALLOON AORTIC VALVULOPLASTY: RESULTS FROM A 2-CENTER REGISTRY', in Journal of the American College of Cardiology, Elsevier Science Inc, http://dx.doi.org/10.1016/s0735-1097(12)60267-8

Working Papers

Hodonsky CJ; Turner AW; Khan MD; Barrientos NB; Methorst R; Ma L; Lopez NG; Mosquera JV; Auguste G; Farber E; Feng W; Wong D; Onengut-Gumuscu S; Kavousi M; Peyser PA; van der Laan SW; Leeper NJ; Kovacic JC; Björkegren JLM; Miller CL, Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/2023.02.09.23285622

Preprints

Schaniel C; Dhanan P; Hu B; Xiong Y; Raghunandan T; Gonzalez DM; Dariolli R; D’Souza SL; Yadaw AS; Hansen J; Jayaraman G; Mathew B; Machado M; Berger SI; Tripodi J; Najfeld V; Garg J; Miller M; Lynch CS; Michelis KC; Tangirala NC; Weerahandi H; Thomas DC; Beaumont KG; Sebra R; Mahajan M; Schadt E; Vidovic D; Schürer SC; Goldfarb J; Azeloglu EU; Birtwistle MR; Sobie EA; Kovacic JC; Dubois NC; Iyengar R, A Library of Induced Pluripotent Stem Cells from Clinically Well-Characterized, Diverse Healthy Human Individuals, http://dx.doi.org/10.1101/2020.10.29.360909

Turner AW; Hu S; Mosquera JV; Feng W; Hodonsky CJ; Wong D; Auguste G; Sol-Church K; Farber E; Kundu S; Kundaje A; Lopez NG; Ma L; Ghosh SKB; Onengut-Gumuscu S; Ashley EA; Quertermous T; Finn AV; Leeper NJ; Kovacic JC; Björkgren JLM; Zang C; Miller CL, Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk, http://dx.doi.org/10.1101/2021.06.07.447388

Zhang M; McGrath-Cadell L; Hesselson S; Shen C; Gharleghi R; Collins N; Muller DW; Kovacic JC; Graham RM; Beier S, CT Coronary Angiography Identifies a Shear-Stress Signature of Spontaneous Coronary Artery Dissection: A Case–Control Study, http://dx.doi.org/10.64898/2026.08.12.26360329

Zhang Z; Cheng H; Hong X; Di Narzo AF; Franzen O; Peng S; Ruusalepp A; Kovacic JC; Bjorkegren JL; Wang X; Hao K, EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data, http://dx.doi.org/10.1101/356667

Trivieri MG; Robson PM; Vergani V; LaRocca G; Romero-Daza AM; Abgral R; Karakatsanis NA; Parikh A; Panagiota C; Palmisano A; DePalo L; Chang HL; Rothstein JH; Fayad RA; Miller MA; Fuster V; Narula J; Dweck MR; Jacobi A; Padilla M; Kovacic JC; Fayad ZA, Evaluating the association between hybrid magnetic resonance positron emission tomography and cardiac-related outcomes in cardiac sarcoidosis, http://dx.doi.org/10.1101/2022.01.13.22269230

Wong D; Auguste G; Cardenas CLL; Turner AW; Chen Y; Ma L; Perry RN; Aherrahrou R; Kuppusamy M; Yang C; Mosquera JV; Dube CJ; Khan MD; Palmore M; Kavousi M; Peyser PA; Matic L; Hedin U; Manichaikul A; Sonkusare SK; Civelek M; Kovacic JC; Björkegren JLM; Malhotra R; Miller CL, FHL5 controls vascular disease-associated gene programs in smooth muscle cells, http://dx.doi.org/10.1101/2022.07.23.501247

Georges A; Yang M-L; Berrandou T-E; Bakker M; Dikilitas O; Kiando SR; Ma L; Satterfield BA; Sengupta S; Yu M; Deleuze J-F; Dupré D; Hunker KL; Kyryachenko S; Liu L; Amar L; Brummett CM; Coleman DM; d’Escamard V; de Leeuw P; Fendrikova-Mahlay N; Kadian-Dodov D; Li JZ; Lorthioir A; Pappaccogli M; Prejbisz A; Smigielski W; Stanley JC; Zawistowski M; Zhou X; Zoellner S; investigators F; group ISGCIAW; Megastroke ; De Buyzere ML; Debette S; Dobrowolski P; Drygas W; Gornik HL; Olin JW; Piwonski J; Rietzschel ER; Ruigrok Y; Vikkula M; Celinska EW; Januszewicz A; Kullo IJ; Azizi M; Jeunemaitre X; Persu A; Kovacic JC; Ganesh SK; Bouatia-Naji N, Genetic association studies of fibromuscular dysplasia identify new risk loci and shared genetic basis with more common vascular diseases, http://dx.doi.org/10.1101/2020.09.16.20195701

Adlam D; Berrandou T-E; Georges A; Nelson CP; Giannoulatou E; Henry J; Ma L; Blencowe M; Turley TN; Yang M-L; Braund PS; Sadeg-Sayoud I; Iismaa SE; Kosel ML; Zhou X; Hamby SE; Cheng J; Liu L; Tarr I; Muller DWM; d’Escamard V; King A; Brunham LR; Baranowska-Clarke AA; Debette S; Amouyel P; Olin JW; Patil S; Hesselson SE; Junday K; Kanoni S; Aragam K; Butterworth AS; CARDIoGRAMPlusC4D ; MEGASTROKE ; group ISGCIAW; Tweet MS; Gulati R; Combaret N; investigators DR; Kadian-Dodov D; Kalman J; Fatkin D; Saw J; Webb TR; Hayes SN; Yang X; Ganesh SK; Olson TM; Kovacic JC; Graham RM; Samani NJ; Bouatia-Naji N, Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation, http://dx.doi.org/10.1101/2022.07.05.22277238

Mosquera JV; Auguste G; Wong D; Turner AW; Hodonsky CJ; Cardenas CLL; Theofilatos K; Bos M; Kavousi M; Peyser PA; Mayr M; Kovacic JC; Björkegren JLM; Malhotra R; van der Laan SW; Zang C; Sheffield NC; Miller CL, Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis, http://dx.doi.org/10.1101/2022.10.24.513520

von Scheidt M; Bauer S; Ma A; Hao K; Kessler T; Vilne B; Wang Y; Hodonsky CJ; Ghosh SKB; Mokry M; Gao H; Kawai K; Sakamoto A; Kaiser J; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Moggio A; Sager HB; Hecker JS; Bassermann F; Maegdefessel L; Miller CL; Koenig W; Zeiher AM; Dimmeler S; Graw M; Braun C; Ruusalepp A; Leeper NJ; Kovacic JC; Björkegren JLM; Schunkert H, Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques, http://dx.doi.org/10.1101/2023.07.22.23292754

Ma F; Liu Y; Xu Y; Liu W; Gupta N; Zhu Y; Xiao L; Traylor JG; Rom O; Kovacic JC; Fidler TP; Yurdagul A; Orr AW; Huang X; Cai B, Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis, http://dx.doi.org/10.1101/2025.10.27.684958

Mosquera JV; Tang I; Murach M; Auguste G; Kodali A; Hart P; Shaw DM; Li M; Turner AW; Hodonsky CJ; Dworak NM; de Oliveira AK; Sol-Church K; Jhee T; van der Sijs KIM; Adkar SS; Choi RB; Vacante F; Wu JC; Cheng P; Giannarelli C; Leeper NJ; Finn AV; Björkegren JLM; Kovacic JC; Yurdagul A; van der Laan SW; Miller CL, Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk, http://dx.doi.org/10.64898/2026.05.24.26353986

Bankier S; Talukdar H; Khan M; Mocci G; Sukhavasi K; Hao K; Ma A; Ruusalepp A; Schadt EE; Kovacic JC; Michoel T; Björkegren JL, Plasma proteins are integral to gene-regulatory networks acting within and across blood cells, the arterial wall and major metabolic organs, http://dx.doi.org/10.1101/2025.01.22.25320723

Georges A; Albuisson J; Berrandou T; Dupré D; Lorthioir A; D’Escamard V; Di Narzo AF; Kadian-Dodov D; Olin JW; Warchol-Celinska E; Prejbisz A; Januszewicz A; Bruneval P; Baranowska AA; Webb TR; Hamby SE; Samani NJ; Adlam D; Fendrikova-Mahlay N; Hazen S; Wang Y; Yang M-L; Hunker K; Combaret N; Motreff P; Chédid A; Fiquet B; Plouin P-F; Mousseaux E; Azarine A; Amar L; Azizi M; Gornik HL; Ganesh SK; Kovacic JC; Jeunemaitre X; Bouatia-Naji N, Rare Loss-of-function Mutations of PTGIR Identified in Fibromuscular Dysplasia and Spontaneous Coronary Artery Dissection, http://dx.doi.org/10.1101/19012484

Yang D; Chen G; Gaurav S; de Jesus AA; Mehta AK; McNinch C; Miranda AX; Wei J; Kedei N; Hernandez MO; Zou J; Linask K; Lee C-C; Sukumar G; Zhang Y; Alehashemi S; Folio L; Yu Q; Lin B; Lang B; Buehring B; Dueckers G; Reinhardt A; Schulte G; Liptzin DR; Ozen S; Borzutzky A; Wong M; Tillo D; Dmitrieva NI; Mani H; Nathan SD; Kovacic JC; Dalgard C; Boehm M; Goldbach-Mansky R, STING–STAT3–SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis, http://dx.doi.org/10.64898/2026.03.23.713256

Schunkert H; Li L; Chen Z; Scheidt M; Steiner A; Güldener U; Koplev S; Ma A; Hao K; Pan C; Lusis A; Pang S; Kessler T; Ermel R; Sukhavasi K; Ruusalepp A; Gagneur J; Erdmann J; Kovacic J; Bjorkegren J, Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes, http://dx.doi.org/10.21203/rs.3.rs-678054/v1

Li L; Chen Z; von Scheidt M; Steiner A; Güldener U; Koplev S; Ma A; Hao K; Pan C; Lusis AJ; Pang S; Kessler T; Ermel R; Sukhavasi K; Ruusalepp A; Gagneur J; Erdmann J; Kovacic JC; Björkegren JLM; Schunkert H, Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes, http://dx.doi.org/10.1101/2021.07.21.453208

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