By Dr Jason Ciril Kovacic

Journal articles

Kini AS; Motoyama S; Vengrenyuk Y; Feig JE; Pena J; Baber U; Bhat AM; Moreno P; Kovacic JC; Narula J; Sharma SK, 2015, 'Multimodality Intravascular Imaging to Predict Periprocedural Myocardial Infarction During Percutaneous Coronary Intervention', Jacc Cardiovascular Interventions, 8, pp. 937 - 945, http://dx.doi.org/10.1016/j.jcin.2015.03.016

Kovacic JC; Fuster V, 2015, 'Cell therapy for patients with acute myocardial infarction: ACCRUEd evidence to date', Circulation Research, 116, pp. 1287 - 1290, http://dx.doi.org/10.1161/CIRCRESAHA.115.306323

Björkegren JLM; Kovacic JC; Dudley JT; Schadt EE, 2015, 'Genome-wide significant loci: How important are they?: Systems genetics to understand heritability of coronary artery disease and other common complex disorders', Journal of the American College of Cardiology, 65, pp. 830 - 845, http://dx.doi.org/10.1016/j.jacc.2014.12.033

Sengupta PP; Wiley BM; Basnet S; Rajamanickman A; Kovacic JC; Fischer GW; Kini AS; Sharma SK, 2015, 'Transthoracic echocardiography guidance for TAVR under monitored anesthesia care', Jacc Cardiovascular Imaging, 8, pp. 379 - 380, http://dx.doi.org/10.1016/j.jcmg.2015.01.002

Kovacic JC; Kini A; Banerjee S; Dangas G; Massaro J; Mehran R; Popma J; O'Neill WW; Sharma SK, 2015, 'Patients with 3-vessel coronary artery disease and impaired ventricular function undergoing PCI with Impella 2.5 hemodynamic support have improved 90-day outcomes compared to intra-aortic balloon pump: A sub-study of the PROTECT II trial', Journal of Interventional Cardiology, 28, pp. 35 - 40, http://dx.doi.org/10.1111/joic.12166

Dohi T; Maehara A; Moreno PR; Baber U; Kovacic JC; Limaye AM; Ali ZA; Sweeny JM; Mehran R; Dangas GD; Xu K; Sharma SK; Mintz GS; Kini AS, 2015, 'The relationship among extent of lipid-rich plaque, lesion characteristics, and plaque progression/regression in patients with coronary artery disease: a serial near-infrared spectroscopy and intravascular ultrasound study', European Heart Journal Cardiovascular Imaging, 16, pp. 81 - 87, http://dx.doi.org/10.1093/ehjci/jeu169

Evrard S; D’Audigier C; Mauge L; Israel-Biet D; Guerin C; Bieche I; Kovacic J; Fischer A-M; Gaussem P; Smadja D, 2015, 'La cytokine fibrogénique TGF-β1 augmente les propriétés angiogéniques des progéniteurs endothéliaux circulants', Morphologie, 99, pp. 151, http://dx.doi.org/10.1016/j.morpho.2015.09.005

Meelu OA; Tomey MI; Sartori S; Kherada N; Mennuni MG; Theodoropoulos KN; Sayeneni S; Baber U; Pyo RT; Kovacic JC; Moreno P; Krishnan P; Mehran R; Dangas GD; Kini AS; Sharma SK, 2014, 'Comparison of provisional 1-stent and 2-stent strategies in diabetic patients with true bifurcation lesions: The EES bifurcation study', Journal of Invasive Cardiology, 26, pp. 619 - 623

Alicea D; Chudnovskiy A; Rodriguez DT; Yang DK; Jeong D; Kovacic JC; Badimon JJ; Weber T; Merad M; Hajjar RJ; Fuster V; Giannarelli C, 2014, 'Abstract 16942: Alternatively Spliced Tissue Factor promotes plaque progression, inflammation and angiogenesis in experimental atherosclerosis', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.16942

Warren JL; Baber U; Yu J; Aquino M; Bhat A; Basnet S; Dangas G; Mehran R; Pyo R; Kovacic J; Sharma SK; Kini AS, 2014, 'Abstract 16974: Gender Differences in Patients Undergoing Transcatheter Aortic Valve Replacement: a Single Center Experience', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.16974

Theodoropoulos K; Yu J; Aquino M; Baber U; Roy S; Kovacic J; Sweeny J; Mehran R; Sharma S; Kini A, 2014, 'Abstract 17007: Does Age Modify Gender-based Differences in Clinical Outcomes Following Percutaneous Coronary Intervention (PCI)', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.17007

Michelis KC; Boehm M; Kovacic JC, 2014, 'New vessel formation in the context of cardiomyocyte regeneration - the role and importance of an adequate perfusing vasculature', Stem Cell Research, 13, pp. 666 - 682, http://dx.doi.org/10.1016/j.scr.2014.04.009

Narula J; Kovacic JC, 2014, 'Putting TCFA in clinical perspective', Journal of the American College of Cardiology, 64, pp. 681 - 683, http://dx.doi.org/10.1016/j.jacc.2014.06.1163

Fuster V; Kovacic JC, 2014, 'Acute coronary syndromes: Pathology, diagnosis, genetics, prevention, and treatment', Circulation Research, 114, pp. 1847 - 1851, http://dx.doi.org/10.1161/CIRCRESAHA.114.302806

Garcia-Garcia HM; Jang IK; Serruys PW; Kovacic JC; Narula J; Fayad ZA, 2014, 'Imaging plaques to predict and better manage patients with acute coronary events', Circulation Research, 114, pp. 1904 - 1917, http://dx.doi.org/10.1161/CIRCRESAHA.114.302745

Kherada NI; Sartori S; Tomey MI; Mennuni MG; Meelu OA; Roy S; Mohanty BD; Baber U; Pyo R; Kovacic JC; Sweeny J; Moreno P; Krishnan P; Dangas GD; Mehran R; Sharma SK; Kini AS, 2014, 'Dedicated two-stent technique in complex bifurcation percutaneous coronary intervention with use of everolimus-eluting stents: The EES-bifurcation study', International Journal of Cardiology, 174, pp. 13 - 17, http://dx.doi.org/10.1016/j.ijcard.2014.03.029

Tomey MI; Narula J; Kovacic JC, 2014, 'Advances in the understanding of plaque composition and treatment options: Year in review', Journal of the American College of Cardiology, 63, pp. 1604 - 1616, http://dx.doi.org/10.1016/j.jacc.2014.01.042

Cooley BC; Nevado J; Mellad J; Yang D; St. Hilaire C; Negro A; Fang F; Chen G; San H; Walts AD; Schwartzbeck RL; Taylor B; Lanzer JD; Wragg A; Elagha A; Beltran LE; Berry C; Feil R; Virmani R; Ladich E; Kovacic JC; Boehm M, 2014, 'TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling', Science Translational Medicine, 6, http://dx.doi.org/10.1126/scitranslmed.3006927

Kovacic JC; Mehran R; Sweeny J; Li JR; Moreno P; Baber U; Krishnan P; Badimon JJ; Hulot JS; Kini A; Sharma SK, 2014, 'Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel', Journal of Cardiovascular Pharmacology and Therapeutics, 19, pp. 201 - 208, http://dx.doi.org/10.1177/1074248413510605

Lipskaia L; Bobe R; Chen J; Turnbull IC; Lopez JJ; Merlet E; Jeong D; Karakikes I; Ross AS; Liang L; Mougenot N; Atassi F; Lompré AM; Tarzami ST; Kovacic JC; Kranias E; Hajjar RJ; Hadri L, 2014, 'Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+-ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells', Circulation, 129, pp. 773 - 785, http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002565

Dangas GD; Maehara A; Evrard SM; Sartori S; Li JR; Chirumamilla AP; Nomura-Kitabayashi A; Gukathasan N; Hassanin A; Baber U; Fahy M; Fuster V; Mintz GS; Kovacic JC, 2014, 'Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: A three-dimensional intravascular ultrasound study', European Heart Journal Cardiovascular Imaging, 15, pp. 201 - 209, http://dx.doi.org/10.1093/ehjci/jet139

Hulot JS; Stillitano F; Salem JE; Kovacic JC; Fuster V; Hajjar RJ, 2014, 'Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes', Stem Cell Research and Therapy, 5, http://dx.doi.org/10.1186/scrt390

Giannarelli C; Alique M; Rodriguez DT; Yang DK; Jeong D; Calcagno C; Hutter R; Millon A; Kovacic JC; Weber T; Faries PL; Soff GA; Fayad ZA; Hajjar RJ; Fuster V; Badimon JJ, 2014, 'Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling', Circulation, 130, pp. 1274 - 1286, http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006614

Roleder T; Kovacic JC; Ali Z; Sharma R; Cristea E; Moreno P; Sharma SK; Narula J; Kini AS, 2014, 'Combined NIRS and IVUS imaging detects vulnerable plaque using a single catheter system: A head-to-head comparison with OCT', Eurointervention, 10, pp. 303 - 311, http://dx.doi.org/10.4244/EIJV10I3A53

Michelis KC; Olin JW; Kadian-Dodov D; D'Escamard V; Kovacic JC, 2014, 'Coronary artery manifestations of fibromuscular dysplasia', Journal of the American College of Cardiology, 64, pp. 1033 - 1046, http://dx.doi.org/10.1016/j.jacc.2014.07.014

Kini A; Yu J; Cohen MG; Mehran R; Baber U; Sartori S; Vlachojannis GJ; Kovacic JC; Pyo R; O'Neill B; Singh V; Jacobs E; Poludasu S; Moreno P; Kim MC; Krishnan P; Sharma SK; Dangas GD, 2014, 'Effect of bivalirudin on aortic valve intervention outcomes study: A two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty', Eurointervention, 10, pp. 312 - 319, http://dx.doi.org/10.4244/EIJV10I3A54

Chaanine AH; Nonnenmacher M; Kohlbrenner E; Jin D; Kovacic JC; Akar FG; Hajjar RJ; Weber T, 2014, 'Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure', Gene Therapy, 21, pp. 379 - 386, http://dx.doi.org/10.1038/gt.2014.7

Kovacic JC; Castellano JM; Farkouh ME; Fuster V, 2014, 'The relationships between cardiovascular disease and diabetes: Focus on pathogenesis', Endocrinology and Metabolism Clinics of North America, 43, pp. 41 - 57, http://dx.doi.org/10.1016/j.ecl.2013.09.007

O'Neill B; Singh V; Kini A; Mehran R; Jacobs E; Knopf D; Alfonso CE; Martinez CA; Martinezclark P; O'Neill W; Heldman AW; Yu J; Baber U; Kovacic JC; Dangas G; Sharma S; Sartori S; Cohen MG, 2014, 'The use of vascular closure devices and impact on major bleeding and net adverse clinical events (NACEs) in balloon aortic valvuloplasty: A sub-analysis of the BRAVO study', Catheterization and Cardiovascular Interventions, 83, pp. 148 - 153, http://dx.doi.org/10.1002/ccd.24892

Kovacic JC; Limaye AM; Sartori S; Lee P; Patel R; Chandela S; Trost B; Roy S; Harari R; Narechania B; Karajgikar R; Kim MC; Krishnan P; Moreno P; Baber U; Mehran R; Dangas G; Kini AS; Sharma SK, 2013, 'Comparison of six risk scores in patients with triple vessel coronary artery disease undergoing PCI: Competing factors influence mortality, myocardial infarction, and target lesion revascularization', Catheterization and Cardiovascular Interventions, 82, pp. 855 - 868, http://dx.doi.org/10.1002/ccd.25008

Ali ZA; Roleder T; Narula J; Mohanty BD; Baber U; Kovacic JC; Mintz GS; Otsuka F; Pan S; Virmani R; Sharma SK; Moreno P; Kini AS, 2013, 'Increased thin-cap neoatheroma and periprocedural myocardial infarction in drug-eluting stent restenosis multimodality intravascular imaging of drug-eluting and bare-metal stents', Circulation Cardiovascular Interventions, 6, pp. 507 - 517, http://dx.doi.org/10.1161/CIRCINTERVENTIONS.112.000248

Yang W; Kovacic JC; Cromwell C; Grosskreutz C; Mascarenhas J, 2013, 'Myocardial infarction in a young man receiving chemotherapy for acute lymphoblastic leukemia', Clinical Advances in Hematology and Oncology, 11, pp. 672 - 675

Mennuni M; Moreno P; Krishnan P; Sharma SK; Sartori S; Kovacic J; Pyo R; Dangas G; Yu J; Kini A, 2013, 'Impact of vascular closure with the pre-closure technique on adverse events in patients undergoing transfemoral balloon aortic valvuloplasty: results from a single-center registry', European Heart Journal, 34, pp. P2208 - P2208, http://dx.doi.org/10.1093/eurheartj/eht308.p2208

Wood KC; Cortese-Krott MM; Kovacic JC; Noguchi A; Liu VB; Wang X; Raghavachari N; Boehm M; Kato GJ; Kelm M; Gladwin MT, 2013, 'Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis', Arteriosclerosis Thrombosis and Vascular Biology, 33, pp. 1861 - 1871, http://dx.doi.org/10.1161/ATVBAHA.112.301068

Kovacic JC; Sharma AB; Roy S; Li JR; Narayan R; Kim DB; Sharma SK; Kini AS, 2013, 'GuideLiner mother-and-child guide catheter extension: A simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions', Journal of Interventional Cardiology, 26, pp. 343 - 350, http://dx.doi.org/10.1111/joic.12040

Pereira CF; Chang B; Qiu J; Niu X; Papatsenko D; Hendry CE; Clark NR; Nomura-Kitabayashi A; Kovacic JC; Ma'Ayan A; Schaniel C; Lemischka IR; Moore K, 2013, 'Induction of a hemogenic program in mouse fibroblasts', Cell Stem Cell, 13, pp. 205 - 218, http://dx.doi.org/10.1016/j.stem.2013.05.024

Kini AS; Baber U; Kovacic JC; Limaye A; Ali ZA; Sweeny J; Maehara A; Mehran R; Dangas G; Mintz GS; Fuster V; Narula J; Sharma SK; Moreno PR, 2013, 'Changes in plaque lipid content after short-term intensive versus standard statin therapy: The YELLOW trial (Reduction in Yellow Plaque by Aggressive Lipid-Lowering Therapy)', Journal of the American College of Cardiology, 62, pp. 21 - 29, http://dx.doi.org/10.1016/j.jacc.2013.03.058

Roleder T; Suh W; Sharma R; Hecht H; Kovacic JC; Narula J; Kini AS, 2013, 'Plaques with high lipid burden: Keeping the fat out of the fire', Heart, 99, pp. 977 - 978, http://dx.doi.org/10.1136/heartjnl-2012-303421

Kovacic JC; Nguyen HT; Karajgikar R; Sharma SK; Kini AS, 2013, 'The impella recover 2.5 and TandemHeart ventricular assist devices are safe and associated with equivalent clinical outcomes in patients undergoing high-risk percutaneous coronary intervention', Catheterization and Cardiovascular Interventions, 82, pp. E28 - E37, http://dx.doi.org/10.1002/ccd.22929

Cubeddu RJ; Palacios IF; Blankenship JC; Horvath SA; Xu K; Kovacic JC; Dangas GD; Witzenbichler B; Guagliumi G; Kornowski R; Dudek D; Stone GW; Mehran R, 2013, 'Outcome of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention during on- versus off-hours (A Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Trial Substudy)', American Journal of Cardiology, 111, pp. 946 - 954, http://dx.doi.org/10.1016/j.amjcard.2012.11.062

Baber U; Bander J; Karajgikar R; Yadav K; Hadi A; Theodoropolous K; Gukathasan N; Roy S; Sayeneni S; Scott SA; Kovacic JC; Yu J; Sartori S; Mehran R; Uribarri J; Badimon JJ; Muntner P; Moreno P; Kini AS; Sharma SK, 2013, 'Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity', Thrombosis and Haemostasis, 110, pp. 118 - 123, http://dx.doi.org/10.1160/TH13-01-0004

Mennuni MG; Theodoropoulos K; Meelu OA; Moreno PR; Krishnan P; Kovacic J; Baber U; Aquino M; Sartori S; Pyo RT; Sweeny J; Dangas G; Mehran R; Sharma S; Kini A, 2013, 'TCT-481 Treatment of "resistant" in-stent restenosis in the drug-eluting era: comparison of repeat stent versus balloon only strategy', Journal of the American College of Cardiology, 62, pp. b147, http://dx.doi.org/10.1016/j.jacc.2013.08.1224

Mennuni MG; Theodoropoulos K; Kherada NI; Aquino M; Baber U; Sartori S; Sayeneni S; Narechania B; Moreno PR; Krishnan P; Kovacic J; Pyo RT; Sweeny J; Dangas G; Mehran R; Sharma S; Kini A, 2013, 'TCT-482 "Resistant" In-Stent Restenosis in the Drug-Eluting Stent Era: An Angiographic Description and Outcomes', Journal of the American College of Cardiology, 62, pp. b147 - b148, http://dx.doi.org/10.1016/j.jacc.2013.08.1225

Kovacic JC; Fuster V, 2012, 'Smoking gun theory: Angiographically normal or mild coronary plaque as a cause of myocardial infarction', Circulation, 126, pp. 2918 - 2920, http://dx.doi.org/10.1161/CIRCULATIONAHA.112.150425

Kovacic JC; Limaye AM; Gukathasan N; Sartori S; Lee P; Trost B; Narechania B; Roy S; Sayeneni S; Kim MC; Moreno PM; Baber U; Mehran R; Dangas G; Kini AS; Sharma SK, 2012, 'Abstract 18591: Anatomically- Versus Clinically-derived Risk Scores Have Markedly Differing Predictive Abilities Following PCI For Multivessel CAD: The “TLR Paradox”', Circulation, 126, http://dx.doi.org/10.1161/circ.126.suppl_21.a18591

Kovacic JC; Limaye AM; Gukathasan N; Sartori S; Trost B; Narechania B; Thapi R; Kim MC; Moreno P; Baber U; Dangas G; Mehran R; Sharma SK; Kini A, 2012, 'Abstract 18677: The ACEF Risk Score Exhibits Superior Predictive Ability for Adverse Clinical Outcomes in Women Undergoing PCI', Circulation, 126, http://dx.doi.org/10.1161/circ.126.suppl_21.a18677

Vlachojannis G; Kini A; Mehran R; Gukathasan N; Cohen M; Yu J; Sergie Z; Baber U; Sartori S; Pyo R; Theodoropoulos K; Thapi R; Roy S; Sayeneni S; Pinnelas R; Jacobs E; Knopf D; Kovacic J; Vadde R; O'Neill B; Sharma SK; Dangas GD, 2012, 'Abstract 18793: Impact of Chronic Kidney Disease on Outcomes in Patients Undergoing Balloon Aortic Valvuloplasty: Results from the BRAVO Study', Circulation, 126, http://dx.doi.org/10.1161/circ.126.suppl_21.a18793

Yu J; Kini A; Cohen M; Sartori S; Baber U; Pyo R; Kovacic J; O'Neill BP; Moreno P; Alfonso CE; Pinnelas R; Varghese C; Kakoulides S; Clarke A; Thapi R; Roy S; Kim M; Mehran R; Dangas G; Sharma SK, 2012, 'Abstract 19521: Impact of Procedural Complications on Survival in Patients with Severe Aortic Stenosis Treated with Balloon Aortic Valvuloplasty: Results from the BRAVO Study', Circulation, 126, http://dx.doi.org/10.1161/circ.126.suppl_21.a19521

Kovacic JC; Fuster V, 2012, 'Atherosclerotic risk factors, vascular cognitive impairment, and alzheimer disease', Mount Sinai Journal of Medicine, 79, pp. 664 - 673, http://dx.doi.org/10.1002/msj.21347

Sharma AB; Kovacic JC; Kini AS, 2012, 'Percutaneous Left Ventricular Assist Devices', Interventional Cardiology Clinics, 1, pp. 609 - 622, http://dx.doi.org/10.1016/j.iccl.2012.07.003

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