By Dr Jason Ciril Kovacic

Journal articles

Fatkin D; Huttner IG; Kovacic JC; Seidman JG; Seidman CE, 2019, 'Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 74, pp. 2921 - 2938, http://dx.doi.org/10.1016/j.jacc.2019.10.011

Glicksberg BS; Amadori L; Akers NK; Sukhavasi K; Franzén O; Li L; Belbin GM; Ayers KL; Shameer K; Badgeley MA; Johnson KW; Readhead B; Darrow BJ; Kenny EE; Betsholtz C; Ermel R; Skogsberg J; Ruusalepp A; Schadt EE; Dudley JT; Ren H; Kovacic JC; Giannarelli C; Li SD; Björkegren JLM; Chen R, 2019, 'Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits (BMC Medical Genomics DOI: 10.1186/s12920-019-0542-3)', BMC Medical Genomics, 12, http://dx.doi.org/10.1186/s12920-019-0573-9

Hulshoff MS; Del Monte-Nieto G; Kovacic J; Krenning G, 2019, 'Non-coding RNA in endothelial-to-mesenchymal transition', Cardiovascular Research, 115, pp. 1716 - 1731, http://dx.doi.org/10.1093/cvr/cvz211

Tadros RO; Tang GHL; Barnes HJ; Mousavi I; Kovacic JC; Faries P; Olin JW; Marin ML; Adams DH, 2019, 'Optimal Treatment of Uncomplicated Type B Aortic Dissection: JACC Review Topic of the Week', Journal of the American College of Cardiology, 74, pp. 1494 - 1504, http://dx.doi.org/10.1016/j.jacc.2019.07.063

Glicksberg BS; Amadori L; Akers NK; Sukhavasi K; Franzén O; Li L; Belbin GM; Akers KL; Shameer K; Badgeley MA; Johnson KW; Readhead B; Darrow BJ; Kenny EE; Betsholtz C; Ermel R; Skogsberg J; Ruusalepp A; Schadt EE; Dudley JT; Ren H; Kovacic JC; Giannarelli C; Li SD; Björkegren JLM; Chen R, 2019, 'Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits', BMC Medical Genomics, 12, http://dx.doi.org/10.1186/s12920-019-0542-3

Guedeney P; Claessen BE; Kalkman DN; Aquino M; Sorrentino S; Giustino G; Farhan S; Vogel B; Sartori S; Montalescot G; Sweeny J; Kovacic JC; Krishnan P; Barman N; Dangas G; Kini A; Baber U; Sharma S; Mehran R, 2019, 'Residual Inflammatory Risk in Patients With Low LDL Cholesterol Levels Undergoing Percutaneous Coronary Intervention (vol 73, pg 2401, 2019)', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 74, pp. 481 - 482, http://dx.doi.org/10.1016/j.jacc.2019.06.009

Tang GHL; Zaid S; Gupta E; Ahmad H; Khan A; Kovacic JC; Lansman SL; Dangas GD; Sharma SK; Kini A, 2019, 'Feasibility of Repeat TAVR After SAPIEN 3 TAVR: A Novel Classification Scheme and Pilot Angiographic Study', JACC: Cardiovascular Interventions, 12, pp. 1290 - 1292, http://dx.doi.org/10.1016/j.jcin.2019.02.020

Tang GHL; Zaid S; Gupta E; Ahmad H; Patel N; Khan M; Khan A; Kovacic JC; Lansman SL; Dangas GD; Sharma SK; Kini A, 2019, 'Impact of Initial Evolut Transcatheter Aortic Valve Replacement Deployment Orientation on Final Valve Orientation and Coronary Reaccess: A Pilot Study', Circulation: Cardiovascular Interventions, 12, http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008044

Zeng L; Talukdar HA; Koplev S; Giannarelli C; Ivert T; Gan LM; Ruusalepp A; Schadt EE; Kovacic JC; Lusis AJ; Michoel T; Schunkert H; Björkegren JLM, 2019, 'Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease', Journal of the American College of Cardiology, 73, pp. 2946 - 2957, http://dx.doi.org/10.1016/j.jacc.2019.03.520

Mahajan AM; Claessen BE; Chandrasekhar J; Sartori S; Aquino M; Baber U; Dangas G; Kovacic JC; Krishnan P; Moreno P; Sweeny J; Barman N; Vijay P; Kini A; Mehran R; Sharma S, 2019, 'Outcomes by Gender and Ethnicity After Percutaneous Coronary Intervention', American Journal of Cardiology, 123, pp. 1941 - 1948, http://dx.doi.org/10.1016/j.amjcard.2019.03.019

Guedeney P; Claessen BE; Baber U; Camaj A; Sorrentino S; Aquino M; Blum M; Chandiramani R; Goel R; Elsayed S; Kovacic JC; Sweeny J; Barman N; Moreno P; Dangas GD; Kini A; Sharma S; Mehran R, 2019, 'Temporal Trends in Statin Prescriptions and Residual Cholesterol Risk in Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention', American Journal of Cardiology, 123, pp. 1788 - 1795, http://dx.doi.org/10.1016/j.amjcard.2019.03.005

Guedeney P; Claessen BE; Kalkman DN; Aquino M; Sorrentino S; Giustino G; Farhan S; Vogel B; Sartori S; Montalescot G; Sweeny J; Kovacic JC; Krishnan P; Barman N; Dangas G; Kini A; Baber U; Sharma S; Mehran R, 2019, 'Residual Inflammatory Risk in Patients With Low LDL Cholesterol Levels Undergoing Percutaneous Coronary Intervention', Journal of the American College of Cardiology, 73, pp. 2401 - 2409, http://dx.doi.org/10.1016/j.jacc.2019.01.077

Price LZ; Faries PL; McKinsey JF; Prakash K; Tang GH; Kovacic JC; Tadros RO, 2019, 'The Epidemiology, Pathophysiology, and Novel Treatment of Calcific Arterial Disease', Surgical technology international, 34, pp. 351 - 358

Fernandez-Jimenez R; Jaslow R; Bansilal S; Santana M; Diaz-Munoz R; Latina J; Soto AV; Vedanthan R; Al-Kazaz M; Giannarelli C; Kovacic JC; Bagiella E; Kasarskis A; Fayad ZA; Hajjar RJ; Fuster V, 2019, 'Child Health Promotion in Underserved Communities: The FAMILIA Trial', Journal of the American College of Cardiology, 73, pp. 2011 - 2021, http://dx.doi.org/10.1016/j.jacc.2019.01.057

Zhang Z; Cheng H; Hong X; DI Narzo AF; Franzen O; Peng S; Ruusalepp A; Kovacic JC; Bjorkegren JLM; Wang X; Hao K, 2019, 'EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data', Nucleic Acids Research, 47, http://dx.doi.org/10.1093/nar/gkz068

Gornik HL; Persu A; Adlam D; Aparicio LS; Azizi M; Boulanger M; Bruno RM; de Leeuw P; Fendrikova-Mahlay N; Froehlich J; Ganesh SK; Gray BH; Jamison C; Januszewicz A; Jeunemaitre X; Kadian-Dodov D; Kim ESH; Kovacic JC; Mace P; Morganti A; Sharma A; Southerland AM; Touzé E; van der Niepen P; Wang J; Weinberg I; Wilson S; Olin JW; Plouin PF, 2019, 'First International Consensus on the diagnosis and management of fibromuscular dysplasia', Vascular Medicine (United Kingdom), 24, pp. 164 - 189, http://dx.doi.org/10.1177/1358863X18821816

Kovacic JC; Dimmeler S; Harvey RP; Finkel T; Aikawa E; Krenning G; Baker AH, 2019, 'Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 73, pp. 190 - 209, http://dx.doi.org/10.1016/j.jacc.2018.09.089

Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Motreff P; Belle L; Dupouy P; Barnay P; Meneveau N; Gilard M; Rioufol G; Range G; Brunel P; Delarche N; Filippi E; Le Bivic L; Harbaoui B; Benamer H; Cayla G; Varenne O; Manzo-Silberman SP; Silvain J; Spaulding C; Caussin C; Gerbaud E; Valy Y; Koning R; Lhermusier T; Champin S; Salengro E; Fluttaz A; Zabalawi A; Cottin Y; Teiger E; Saint-Etienne C; Ducrocq G; Marliere S; Boiffard E; Aubry P; Georges JL; Bresson D; De Poli F; Karrillon G; Roule V; Bali L; Valla M; Gerbay A; Houpe D; Dubreuil O; Monnier A; Mayaud N; Manchuelle A; Commeau P; Bedossa M; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085

Gornik HL; Persu A; Adlam D; Aparicio LS; Azizi M; Boulanger M; Bruno RM; De Leeuw P; Fendrikova-Mahlay N; Froehlich J; Ganesh SK; Gray BH; Jamison C; Januszewicz A; Jeunemaitre X; Kadian-Dodov D; Kim ESH; Kovacic JC; MacE P; Morganti A; Sharma A; Southerland AM; Touzé E; Van Der Niepen P; Wang J; Weinberg I; Wilson S; Olin JW; Plouin PF, 2019, 'First international consensus on the diagnosis and management of fibromuscular dysplasia', Journal of Hypertension, 37, pp. 229 - 252, http://dx.doi.org/10.1097/HJH.0000000000002019

Frades I; Readhead B; Amadori L; Koplev S; Talukdar HA; Crane HM; Crane PK; Kovacic JC; Dudley JT; Giannarelli C; Björkegren JLM; Peter I, 2019, 'Systems pharmacology identifies an arterial wall regulatory gene network mediating coronary artery disease side effects of antiretroviral therapy', Circulation: Genomic and Precision Medicine, 12, pp. 262 - 272, http://dx.doi.org/10.1161/CIRCGEN.118.002390

Guedeney P; Baber U; Claessen B; Aquino M; Camaj A; Sorrentino S; Vogel B; Farhan S; Faggioni M; Chandrasekhar J; Kalkman DN; Kovacic JC; Sweeny J; Barman N; Moreno P; Vijay P; Shah S; Dangas G; Kini A; Sharma S; Mehran R, 2019, 'Temporal trends, determinants, and impact of high-intensity statin prescriptions after percutaneous coronary intervention: Results from a large single-center prospective registry', American Heart Journal, 207, pp. 10 - 18, http://dx.doi.org/10.1016/j.ahj.2018.09.001

Kalkman DN; Aquino M; Claessen BE; Baber U; Guedeney P; Sorrentino S; Vogel B; De Winter RJ; Sweeny J; Kovacic JC; Shah S; Vijay P; Barman N; Kini A; Sharma S; Dangas GD; Mehran R, 2018, 'Residual inflammatory risk and the impact on clinical outcomes in patients after percutaneous coronary interventions', European Heart Journal, 39, pp. 4101 - 4108, http://dx.doi.org/10.1093/eurheartj/ehy633

Peng S; Deyssenroth MA; Di Narzo AF; Cheng H; Zhang Z; Lambertini L; Rusualepp A; Kovacic JC; Bjorkegren JLM; Marsit CJ; Chen J; Hao K, 2018, 'Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity', PLoS Genetics, 14, http://dx.doi.org/10.1371/journal.pgen.1007799

Robson PM; Trivieri MG; Karakatsanis NA; Padilla M; Abgral R; Dweck MR; Kovacic JC; Fayad ZA, 2018, 'Correction of respiratory and cardiac motion in cardiac PET/MR using MR-based motion modeling', Physics in Medicine and Biology, 63, http://dx.doi.org/10.1088/1361-6560/aaea97

Williams JW; Giannarelli C; Rahman A; Randolph GJ; Kovacic JC, 2018, 'Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (Part 1)', Journal of the American College of Cardiology, 72, pp. 2166 - 2180, http://dx.doi.org/10.1016/j.jacc.2018.08.2148

Moore KJ; Koplev S; Fisher EA; Tabas I; Björkegren JLM; Doran AC; Kovacic JC, 2018, 'Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2)', Journal of the American College of Cardiology, 72, pp. 2181 - 2197, http://dx.doi.org/10.1016/j.jacc.2018.08.2147

Fayad ZA; Swirski FK; Calcagno C; Robbins CS; Mulder W; Kovacic JC, 2018, 'Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3)', Journal of the American College of Cardiology, 72, pp. 2198 - 2212, http://dx.doi.org/10.1016/j.jacc.2018.08.2150

Lavine KJ; Pinto AR; Epelman S; Kopecky BJ; Clemente-Casares X; Godwin J; Rosenthal N; Kovacic JC, 2018, 'The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4)', Journal of the American College of Cardiology, 72, pp. 2213 - 2230, http://dx.doi.org/10.1016/j.jacc.2018.08.2149

Kovacic JC, 2018, 'The Endothelial–Metabolic Axis: A Novel Cardiometabolic Disease Target', Trends in Endocrinology and Metabolism, 29, pp. 527 - 529, http://dx.doi.org/10.1016/j.tem.2018.03.015

Michelis KC; Nomura-Kitabayashi A; Lecce L; Franzén O; Koplev S; Xu Y; Santini MP; D'Escamard V; Lee JTL; Fuster V; Hajjar R; Reddy RC; Chikwe J; Stelzer P; Filsoufi F; Stewart A; Anyanwu A; Björkegren JLM; Kovacic JC, 2018, 'CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries', Stem Cell Reports, 11, pp. 242 - 257, http://dx.doi.org/10.1016/j.stemcr.2018.06.001

Sherifi I; Omar AMS; Varghese M; Weiner M; Anyanwu A; Kovacic JC; Sharma S; Kini A; Sengupta PP, 2018, 'Comparison of transesophageal and transthoracic echocardiography under moderate sedation for guiding transcatheter aortic valve replacement', Echo Research and Practice, 5, pp. 79 - 87, http://dx.doi.org/10.1530/ERP-17-0080

Copeland-Halperin RS; Baber U; Aquino M; Rajamanickam A; Roy S; Hasan C; Barman N; Kovacic JC; Moreno P; Krishnan P; Sweeny JM; Mehran R; Dangas G; Kini AS; Sharma SK, 2018, 'Prevalence, correlates, and impact of coronary calcification on adverse events following PCI with newer-generation DES: Findings from a large multiethnic registry', Catheterization and Cardiovascular Interventions, 91, pp. 859 - 866, http://dx.doi.org/10.1002/ccd.27204

Watanabe S; Fish K; Kovacic JC; Bikou O; Leonardson L; Nomoto K; Aguero J; Kapur NK; Hajjar RJ; Ishikawa K, 2018, 'Left ventricular unloading using an impella CP improves coronary flow and infarct zone perfusion in ischemic heart failure', Journal of the American Heart Association, 7, http://dx.doi.org/10.1161/JAHA.117.006462

Franzén O; Ermel R; Sukhavasi K; Jain R; Jain A; Betsholtz C; Giannarelli C; Kovacic JC; Ruusalepp A; Skogsberg J; Hao K; Schadt EE; Björkegren JLM, 2018, 'Global analysis of A-to-I RNA editing reveals association with common disease variants', PeerJ, 2018, http://dx.doi.org/10.7717/peerj.4466

Dweck MR; Abgral R; Trivieri MG; Robson PM; Karakatsanis N; Mani V; Palmisano A; Miller MA; Lala A; Chang HL; Sanz J; Contreras J; Narula J; Fuster V; Padilla M; Fayad ZA; Kovacic JC, 2018, 'Hybrid Magnetic Resonance Imaging and Positron Emission Tomography With Fluorodeoxyglucose to Diagnose Active Cardiac Sarcoidosis', JACC: Cardiovascular Imaging, 11, pp. 94 - 107, http://dx.doi.org/10.1016/j.jcmg.2017.02.021

Hajjar RJ; Ishikawa K; Kovacic JC; Fuster V, 2017, 'Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai Translational Mission', Circulation Research, 121, pp. 1316 - 1319, http://dx.doi.org/10.1161/CIRCRESAHA.117.311372

Pena J; Vengrenyuk Y; Kezbor S; Yoshimura T; Kovacic JC; Sharma SK; Baber U; Kini AS; Narula J; Moreno PR, 2017, 'Increased Lipid Length, Macrophage Infiltration, and Neovascularization in Coronary Atheroma From Patients With Chronic Kidney Disease', JACC: Cardiovascular Imaging, 10, pp. 1524 - 1526, http://dx.doi.org/10.1016/j.jcmg.2017.01.019

Robson PM; Dweck MR; Trivieri MG; Abgral R; Karakatsanis NA; Contreras J; Gidwani U; Narula JP; Fuster V; Kovacic JC; Fayad ZA, 2017, 'Coronary Artery PET/MR Imaging: Feasibility, Limitations, and Solutions', JACC: Cardiovascular Imaging, 10, pp. 1103 - 1112, http://dx.doi.org/10.1016/j.jcmg.2016.09.029

Sack MN; Fyhrquist FY; Saijonmaa OJ; Fuster V; Kovacic JC, 2017, 'Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series', Journal of the American College of Cardiology, 70, pp. 196 - 211, http://dx.doi.org/10.1016/j.jacc.2017.05.034

Münzel T; Camici GG; Maack C; Bonetti NR; Fuster V; Kovacic JC, 2017, 'Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series', Journal of the American College of Cardiology, 70, pp. 212 - 229, http://dx.doi.org/10.1016/j.jacc.2017.05.035

Niemann B; Rohrbach S; Miller MR; Newby DE; Fuster V; Kovacic JC, 2017, 'Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series', Journal of the American College of Cardiology, 70, pp. 230 - 251, http://dx.doi.org/10.1016/j.jacc.2017.05.043

Johnson KW; Shameer K; Glicksberg BS; Readhead B; Sengupta PP; Björkegren JLM; Kovacic JC; Dudley JT, 2017, 'Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine', JACC: Basic to Translational Science, 2, pp. 311 - 327, http://dx.doi.org/10.1016/j.jacbts.2016.11.010

Krishnamoorthy P; Vengrenyuk Y; Ueda H; Yoshimura T; Pena J; Motoyama S; Baber U; Hasan C; Kesanakurthy S; Sweeny JM; Sharma SK; Narula J; Kovacic JC; Kini AS, 2017, 'Three-dimensional volumetric assessment of coronary artery calcification in patients with stable coronary artery disease by OCT', EuroIntervention, 13, pp. 312 - 319, http://dx.doi.org/10.4244/EIJ-D-16-00139

Abgral R; Dweck MR; Trivieri MG; Robson PM; Karakatsanis N; Mani V; Padilla M; Miller M; Lala A; Sanz J; Narula J; Fuster V; Contreras J; Kovacic JC; Fayad ZA, 2017, 'Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease', JACC: Cardiovascular Imaging, 10, pp. 594 - 597, http://dx.doi.org/10.1016/j.jcmg.2016.02.029

Bansilal S; Vedanthan R; Kovacic JC; Soto AV; Latina J; Björkegren JL; Jaslow R; Santana M; Sartori S; Giannarelli C; Mani V; Hajjar R; Schadt E; Kasarskis A; Fayad ZA; Fuster V, 2017, 'Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)', American Heart Journal, 187, pp. 170 - 181, http://dx.doi.org/10.1016/j.ahj.2017.02.020

Farhan S; Baber U; Vogel B; Aquino M; Chandrasekhar J; Faggioni M; Giustino G; Kautzky-Willer A; Sweeny J; Shah S; Vijay P; Barman N; Moreno P; Kovacic J; Dangas G; Kini A; Mehran R; Sharma S, 2017, 'Impact of Diabetes Mellitus on Ischemic Events in Men and Women After Percutaneous Coronary Intervention', American Journal of Cardiology, 119, pp. 1166 - 1172, http://dx.doi.org/10.1016/j.amjcard.2016.12.035

Krishnan P; Tarricone A; Purushothaman KR; Purushothaman M; Vasquez M; Kovacic J; Baber U; Kapur V; Gujja K; Kini A; Sharma S, 2017, 'An Algorithm for the Use of Embolic Protection During Atherectomy for Femoral Popliteal Lesions', JACC: Cardiovascular Interventions, 10, pp. 403 - 410, http://dx.doi.org/10.1016/j.jcin.2016.12.014

Kovacic JC, 2017, 'Unraveling the Complex Genetics of Coronary Artery Disease', Journal of the American College of Cardiology, 69, pp. 837 - 840, http://dx.doi.org/10.1016/j.jacc.2016.12.007

Evrard SM; Lecce L; Michelis KC; Nomura-Kitabayashi A; Pandey G; Purushothaman KR; d'Escamard V; Li JR; Hadri L; Fujitani K; Moreno PR; Benard L; Rimmele P; Cohain A; Mecham B; Randolph GJ; Nabel EG; Hajjar R; Fuster V; Boehm M; Kovacic JC, 2017, 'Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability', Nature communications, 8, pp. 14710, http://dx.doi.org/10.1038/ncomms14710

Kini AS; Vengrenyuk Y; Shameer K; Maehara A; Purushothaman M; Yoshimura T; Matsumura M; Aquino M; Haider N; Johnson KW; Readhead B; Kidd BA; Feig JE; Krishnan P; Sweeny J; Milind M; Moreno P; Mehran R; Kovacic JC; Baber U; Dudley JT; Narula J; Sharma S, 2017, 'Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes After Intensive Statin Treatment: The YELLOW II Study', Journal of the American College of Cardiology, 69, pp. 628 - 640, http://dx.doi.org/10.1016/j.jacc.2016.10.029

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