By Professor Edna Hardeman

Journal articles

Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; Dasgupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', AMERICAN JOURNAL OF PATHOLOGY, 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Lindqvist J; Levy Y; Pati-Alam A; Hardeman EC; Gregorevic P; Ochala J, 2016, 'Modulating myosin restores muscle function in a mouse model of nemaline myopathy', Annals of Neurology, 79, pp. 717 - 725, http://dx.doi.org/10.1002/ana.24619

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, pp. 19816, http://dx.doi.org/10.1038/srep19816

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342

Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0

Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC; Yang Ai S, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282

Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188

Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, 10, pp. e0126214, http://dx.doi.org/10.1371/journal.pone.0126214

Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453

Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lindqvist J; Hardeman EC; Ochala J, 2014, 'Sexually dimorphic myofilament function in a mouse model of nemaline myopathy', Archives of Biochemistry and Biophysics, 564, pp. 37 - 42, http://dx.doi.org/10.1016/j.abb.2014.09.011

Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202

Gineste C; Ottenheijm C; Fur YL; Banzet S; Pecchi E; Vilmen C; Cozzone PJ; Koulmann N; Hardeman EC; Bendahan D; Gondin J, 2014, 'Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of Nemaline myopathy', PLoS ONE, 9, pp. e109066, http://dx.doi.org/10.1371/journal.pone.0109066

Head SI; Houweling PJ; Chan S; Chen G; Hardeman EC, 2014, 'Properties of regenerated mouse extensor digitorum longus muscle following notexin injury', Experimental Physiology, 99, pp. 664 - 674, http://dx.doi.org/10.1113/expphysiol.2013.077289

Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293

Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011

Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287

Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501

Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture', BioArchitecture, 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966

Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Davies KE; Laing NG; Nowak KJ, 2013, 'Cardiac alpha-actin over-expression therapy in dominant ACTA1 disease', Human Molecular Genetics, pp. 1 - 11, http://dx.doi.org/10.1093/hmg/ddt252

Gineste C; Le FY; Vilmen C; Le TA; Pecchi E; Cozzone PJ; Hardeman EC; Bendahan D; Gondin J, 2013, 'Combined MRI and 31P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism', PLoS ONE, 8, pp. e61517, http://dx.doi.org/10.1371/journal.pone.0061517

Lindqvist J; Cheng AJ; Renaud G; Hardeman E; Ochala J, 2013, 'Distinct Underlying Mechanisms of Limb and Respiratory Muscle Fiber Weaknesses in Nemaline Myopathy', Journal of Neuropathology and Experimental Neurology, 72, pp. 472 - 481, http://dx.doi.org/10.1097/NEN.0b013e318293b1cc

Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489

Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan Y-KA; Yeo J-L; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/​jcs.102798

Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TY; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.', Neurobiology of Disease, 45, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010

Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation', PLoS ONE, 7, pp. e49283 pg 1 - e49283 pg 10, http://dx.doi.org/10.1371/journal.pone.0049283

Nguyen MA; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.', Brain, 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274

Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, 142, pp. 387 - 397

Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Tay ES; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', The Journal of Biological Chemistry, 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660

Leong GM; Kee AJ; Millard SM; Martel N; Eriksson N; Turner N; Cooney GJ; Hardeman EC; Muscat GE, 2010, 'The Ski proto-oncogene regulates body composition and suppresses lipogenesis.', International journal of obesity, 34, pp. 524 - 536, http://dx.doi.org/10.1038/ijo.2009.265

Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, 66, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400

Vlahovich N; Kee AJ; Van der Poel C; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, 20, pp. 400 - 409, http://www.molbiolcell.org/cgi/content/abstract/E08-06-0616v1

Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, 30, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x

Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28

MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380

Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJ; Hardeman EC; Wieczorek DF; O'Neill GM; Gunning PW, 2008, 'Divergent regulation of the sarcomere and the cytoskeleton', The Journal of Biological Chemistry, 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.M704392200

Cowling BS; McGrath MJ; Nguyen MA; Cottle DL; Kee AJ; Brown S; Schessl J; Zou Y; Joya J; Bonnemann CG; Hardeman EC; Mitchell CA, 2008, 'Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy', Journal of Cell Biology, 183, pp. 1033 - 1048, http://dx.doi.org/10.1083/jcb.200804077

Chang AC; Hook J; Lemckert FA; McDonald M; Nguyen MA; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219

Vlahovich N; Schevzov G; Nair-Shaliker V; Ilkovski B; Artap ST; Kee AJ; North KN; Gunning PW; Hardeman EC, 2008, 'Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle', Cell Motility and the Cytoskeleton, 65, pp. 73 - 85, http://dx.doi.org/10.1002/cm.20245

Gunning PW; O'Neill G; Hardeman EC, 2008, 'Tropomyosin-based regulation of the actin cytoskeleton in time and space', Physiological Reviews, 88, pp. 1 - 35

Kee AJ; Hardeman EC, 2008, 'Tropomyosins in skeletal muscle diseases', , pp. 143 - 154

Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008

MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y; Hardeman EC; Gunning PW; Easteal S; Yang N; North KN, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, 39, pp. 1261 - 1265

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