By Professor Merlin Crossley

Journal articles

Burdach J; Funnell APW; Mak KS; Artuz CM; Wienert B; Lim WF; Tan LY; Pearson RCM; Crossley M, 2014, 'Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor', Nucleic Acids Research, 42, pp. 276 - 289, http://dx.doi.org/10.1093/nar/gkt895

Funnell APW; Crossley M, 2014, 'Hemophilia B Leyden and once mysterious cis-regulatory mutations', Trends in Genetics, 30, pp. 18 - 23, http://dx.doi.org/10.1016/j.tig.2013.09.007

Ballester B; Medina-Rivera A; Schmidt D; Gonzàlez-Porta M; Carlucci M; Chen X; Chessman K; Faure AJ; Funnell APW; Goncalves A; Kutter C; Lukk M; Menon S; McLaren WM; Stefflova K; Watt S; Weirauch MT; Crossley M; Marioni JC; Odom DT; Flicek P; Wilson MD, 2014, 'Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways', eLife, 3, pp. e02626, http://dx.doi.org/10.7554/eLife.02626

Knights AJ; Funnell AP; Pearson RC; Crossley M; Bell-Anderson KS, 2014, 'Adipokines and insulin action: A sensitive issue', Adipocyte, 3, pp. 88 - 96, http://dx.doi.org/10.4161/adip.27552

Berber S; Llamosas E; Thaivalappil P; Boag PR; Crossley M; Nicholas HR, 2013, 'Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans', Developmental Dynamics, 242, pp. 1250 - 1261, http://dx.doi.org/10.1002/dvdy.24023

Mackay JP; Segal DJ; Crossley M, 2013, 'Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?', Trends in Biochemical Sciences, 38, pp. 421 - 422, http://dx.doi.org/10.1016/j.tibs.2013.06.005

Funnell APW; Mak KS; Twine NA; Pelka GJ; Norton LJ; Radziewic T; Power M; Wilkins MR; Bell-Anderson KS; Fraser ST; Perkins AC; Tam PP; Pearson RCM; Crossley M, 2013, 'Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing', Molecular and Cellular Biology, 33, pp. 2976 - 2987, http://dx.doi.org/10.1128/MCB.00074-13

Kelsey L; Flenniken AM; Qu D; Funnell APW; Pearson R; Zhou YQ; Voronina I; Berberovic Z; Wood G; Newbigging S; Weiss ES; Wong M; Quach I; Yeh SYS; Deshwar AR; Scott IC; McKerlie C; Henkelman M; Backx P; Simpson J; Osborne L; Rossant J; Crossley M; Bruneau B; Adamson SL, 2013, 'ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice', PLoS Genetics, 9, pp. e1003612, http://dx.doi.org/10.1371/journal.pgen.1003612

Bell-Anderson KS; Funnell AP; Williams H; Mat Jusoh H; Scully T; Lim WF; Burdach J; Mak KS; Knights AJ; Hoy AJ; Nicholas HR; Sainsbury A; Turner N; Pearson R; Crossley M, 2013, 'Loss of Krüppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).', , http://dx.doi.org/10.2337/db12-1745

Funnell AP; Wilson M; Ballester B; Mak KS; Burdach J; Magan N; Pearson RC; Lemaigre F; Stowell K; Odom D; Flicek P; Crossley M, 2013, 'A CpG Mutational Hotspot in a ONECUT Binding Site Accounts for the Prevalent Variant of Hemophilia B Leyden', American Journal of Human Genetics, 92, pp. 460 - 467, http://dx.doi.org/10.1016/j.ajhg.2013.02.003

Vandevenne M; Jacques DA; Artuz C; Nguyen CD; Kwan AH; Segal DJ; Matthews JM; Crossley M; Guss JM; Mackay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', J Biol Chem, 288, pp. 10616 - 10627, http://dx.doi.org/10.1074/jbc.M112.441451

Bendak K; Loughlin FE; Cheung V; O'Connell MR; Crossley M; MacKay JP, 2012, 'A rapid method for assessing the RNA-binding potential of a protein', Nucleic Acids Research, 40, http://dx.doi.org/10.1093/nar/gks285

Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012

Knights A; Funnell AP; Crossley M; Pearson RC, 2012, 'Holding tight: cell junctions and cancer spread', Trends in Cancer Research, 8, pp. 61 - 69, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582402/

Crossley M; Funnell AP, 2012, 'Homo- and heterodimerization in transcriptional regulation.', Advances in Experimental Medicine and Biology, 747, pp. 105 - 121, http://dx.doi.org/10.1007/978-1-4614-3229-6_7

Funnell AP; Norton LJ; Mak KS; Burdach J; Artuz CM; Twine NA; Wilkins MR; Power C; Hung TT; Perdomo JS; Bell-Anderson K; Orkin SH; Pearson RC; Crossley M, 2012, 'The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo', Molecular and Cellular Biology, 32, pp. 3281 - 3292, http://dx.doi.org/10.1128/MCB.00173-12

Burdach J; O'Connell M; Mackay JP; Crossley M, 2012, 'Two-timing zinc finger transcription factors liaising with RNA', Trends in Biochemical Sciences, 37, pp. 199 - 205, http://dx.doi.org/10.1016/j.tibs.2012.02.001

Jack BH; Pearson RC; Crossley M, 2011, 'C-terminal binding protein: A metabolic sensor implicated in regulating adipogenesis', International Journal of Biochemistry and Cell Biology, 43, pp. 693 - 696, http://dx.doi.org/10.1016/j.biocel.2011.01.017

Crossley M; Norton LJ; Funnell AP; Pearson R, 2011, 'Cellular reprogramming toward the erythroid lineage', International Journal of Cell Biology, pp. Art. No. 501464, http://dx.doi.org/10.1155/2011/501464

Vu TT; Gatto D; Turner V; Funnell AP; Mak KS; Norton LJ; Kaplan W; Cowley MJ; Agenes F; Kirberg J; Brink R; Pearson RC; Crossley M, 2011, 'Impaired B cell development in the absence of Kruppel-like Factor 3.', Journal of Immunology, 187, pp. 5032 - 5042, http://dx.doi.org/10.4049/jimmunol.1101450

Turchinovich G; Vu TT; Frommer F; Kranich J; Schmid S; Alles M; Loubert JB; Goulet JP; Zimber-Strobl U; Schneider P; Bachl J; Pearson RC; Crossley M; Agenes F; Kirberg J, 2011, 'Programming of marginal zone B cell fate by basic krüppel-like factor (BKLF/KLF3)', Blood, 117, pp. 3780 - 3792

Wissmueller S; Font J; Liew CW; Cram ED; Schroeder T; Turner J; Crossley M; Mackay JP; Matthews JM, 2011, 'Protein-protein interactions: Analysis of a false positive GST pulldown result', Proteins - Structure Function and Bioinformatics, 79, pp. 2365 - 2371, http://dx.doi.org/10.1002/prot.23068

Mak KS; Funnell AP; Pearson RC; Crossley M, 2011, 'PU.1 and haematopoietic cell fate: Dosage matters', International Journal of Cell Biology, pp. Art. No. 808524, http://dx.doi.org/10.1155/2011/808524

Wilkinson-White L; Gamsjaeger R; Dastmalchi S; Weinert B; Stokes P; Crossley M; Mackay JP; Matthews JM, 2011, 'Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 14443 - 14448

Pearson RC; Funnell AP; Crossley M, 2011, 'The mammalian transcription factor Krüppel-like Factor 3 (KLF3/BKLF)', IUBMB Life, 63, pp. 86 - 93

Nunez N; Clifton MM; Funnell AP; Artuz CM; Hallal S; Quinlan KG; Font J; Vandevenne M; Setiyaputra S; Pearson RC; Mackay JP; Crossley M, 2011, 'The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain', The Journal of Biological Chemistry, 286, pp. 38190 - 38201, http://dx.doi.org/10.1074/jbc.M111.301234

Jack B; Crossley M, 2010, 'GATA Proteins Work Together with Friend of GATA (FOG) and C-terminal Binding Protein (CTBP) Co-regulators to Control', The Journal of Biological Chemistry, 285, pp. 32405 - 32414, http://dx.doi.org/10.1074/jbc.M110.141317

Pearson RC; Crossley M, 2010, 'KLF3 regulates muscle-specific gene expression and synergizes with serum response factor on KLF binding site', Molecular and Cellular Biology, 30, pp. 3430 - 3443, http://dx.doi.org/10.1128/MCB.00302-10

Natalie Winteringham L; Endersby R; Beaumont J; Lalonde J-P; Crossley M; Klinken SP, 2009, 'Hls5, a Novel Ubiquitin E3 Ligase, Modulates Levels of Sumoylated GATA-1.', Blood, 114, pp. 253 - 253, http://dx.doi.org/10.1182/blood.v114.22.253.253

Pearson R; Funnel APW; Kwok A; Keys J; Tallack M; Hodge D; Perkins AC; Crossley M, 2007, 'The regulation of gene repression by BKLF', BLOOD CELLS MOLECULES AND DISEASES, 38, pp. 133 - 134, http://dx.doi.org/10.1016/j.bcmd.2006.10.035

Funnell APW; Keys J; Tallack M; Hodge D; Perkins AC; Crossley M, 2007, 'Identification of a novel, erythroid BKLF promoter', Blood Cells, Molecules, and Diseases, 38, pp. 139 - 140, http://dx.doi.org/10.1016/j.bcmd.2006.10.049

Marreiros A; Dudgeon K; Dao V; Grimm MO; Czolij R; Crossley M; Jackson P, 2005, '884KAI1 promoter activity is dependent on P53, junb and AP2: Evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells', European Urology Supplements, 4, pp. 223 - 223, http://dx.doi.org/10.1016/s1569-9056(05)80888-7

Simpson RJY; Lee SHY; Bartle N; Sum EY; Visvader JE; Matthews JM; Mackay JP; Crossley M, 2004, 'Classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3', Journal of Biological Chemistry, 279, pp. 39789 - 39797, http://dx.doi.org/10.1074/jbc.M404130200

Verger A; Crossley M, 2004, 'Chromatin modifiers in transcription and DNA repair', Cellular and Molecular Life Sciences, 61, pp. 2154 - 2162, http://dx.doi.org/10.1007/s00018-004-4176-y

Eisbacher M; Holmes ML; Newton A; Hogg PJ; Khachigian LM; Crossley M; Chong BH, 2004, 'Erratum: Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding (Molecular and Cellular Biology (2003) 23, 10 (3427-3441))', Molecular and Cellular Biology, 24, pp. 5088, http://dx.doi.org/10.1128/MCB.24.11.5088.2004

Luo Q; Ma X; Wahl SM; Bieker JJ; Crossley M; Montaner LJ, 2004, 'Activation and Repression of Interleukin-12 p40 Transcription by Erythroid Kruppel-like Factor in Macrophages', Journal of Biological Chemistry, 279, pp. 18451 - 18456, http://dx.doi.org/10.1074/jbc.M400320200

Pizzuti A; Sarkozy A; Newton AL; Conti E; Flex E; Digilio MC; Amati F; Gianni D; Tandoi C; Marino B; Crossley M; Dallapiccola B, 2003, 'Erratum: Mutations of ZFPM2/FOG2 Gene in Sporadic Cases of Tetralogy of Fallot (Human Mutation (2003) 22 (372-377))', Human Mutation, 22, pp. 494 - 495, http://dx.doi.org/10.1002/humu.10308

Pizzuti A; Sarkozy A; Newton AL; Conti E; Flex E; Digilio MC; Amati F; Gianni D; Tandoi C; Marino B; Crossley M; Dallapiccola B, 2003, 'Mutations of ZFPM2/FOG2 Gene in Sporadic Cases of Tetralogy of Fallot', Human Mutation, 22, pp. 372 - 377, http://dx.doi.org/10.1002/humu.10261

Simpson RJY; Cram ED; Czolij R; Matthews JM; Crossley M; Mackay JP, 2003, 'CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions', Journal of Biological Chemistry, 278, pp. 28011 - 28018, http://dx.doi.org/10.1074/jbc.M211146200

Kwan AHY; Gell DA; Verger A; Crossley M; Matthews JM; Mackay JP, 2003, 'Engineering a protein scaffold from a PHD finger', Structure, 11, pp. 803 - 813, http://dx.doi.org/10.1016/S0969-2126(03)00122-9

Turner J; Nicholas H; Bishop D; Matthews JM; Crossley M, 2003, 'The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2', Journal of Biological Chemistry, 278, pp. 12786 - 12795, http://dx.doi.org/10.1074/jbc.M300587200

Kwan AHY; Czolij R; Mackay JP; Crossley M, 2003, 'Pentaprobe: a comprehensive sequence for the one-step detection of DNA-binding activities.', Nucleic acids research, 31, http://dx.doi.org/10.1093/nar/gng124

Crossley M, 2003, 'Transcriptional Treats', BioEssays, 25, pp. 190 - 192, http://dx.doi.org/10.1002/bies.10235

Kowalski K; Liew CK; Matthews JM; Gell DA; Crossley M; Mackay JP, 2002, 'Characterization of the conserved interaction between GATA and FOG family proteins', Journal of Biological Chemistry, 277, pp. 35720 - 35729, http://dx.doi.org/10.1074/jbc.M204663200

Sharpe BK; Matthews JM; Kwan AHY; Newton A; Gell DA; Crossley M; Mackay JP, 2002, 'A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution', Structure, 10, pp. 639 - 648, http://dx.doi.org/10.1016/S0969-2126(02)00757-8

Perdomo JS, 2002, 'The Ikaros family protein Eos associates with C-terminal-binding protein corepressors', European Journal of Biochemistry, 269, pp. 5885 - 5892, http://dx.doi.org/10.1046/j.1432-1033.2002.03313.x

Eisbacher M; Newton A; Holmes ML; Khachigian LM; Crossley M; Chong BH, 2001, 'The protein-protein interaction between FLI-1 and GATA-1 is crucial for expression of the megakaryocyte-specific gene Glycoprotein IX.', BLOOD, 98, pp. 286A - 286A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172134101211&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mehaffey MG; Newton AL; Gandhi MJ; Crossley M; Drachman JG, 2001, 'X-linked thrombocytopenia caused by a novel mutation of GATA-1', Blood, 98, pp. 2681 - 2688, http://dx.doi.org/10.1182/blood.V98.9.2681

Sathasivam P; Bailey AM; Crossley M; Byrne JA, 2001, 'The role of the coiled-coil motif in interactions mediated by TPD52', Biochemical and Biophysical Research Communications, 288, pp. 56 - 61, http://dx.doi.org/10.1006/bbrc.2001.5721

Newton A; Mackay J; Crossley M, 2001, 'The N-terminal Zinc Finger of the Erythroid Transcription Factor GATA-1 Binds GATC Motifs in DNA', Journal of Biological Chemistry, 276, pp. 35794 - 35801, http://dx.doi.org/10.1074/jbc.M106256200

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