By Professor Jamie Vandenberg

Conference Abstracts

Beattie KA; Bardenet R; Louttit JB; Vandenberg JI; Hill AP; Gavaghan DJ; de Boer TP; Mirams GR, 2017, 'Mathematical Modelling of hERG Channel Kinetics Using Sinusoidal Voltage Protocols', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, Vol. 88, pp. 195 - 196, http://dx.doi.org/10.1016/j.vascn.2017.09.089

Mann SA; Vandenberg JI; Hill AP, 2016, 'Sudden Infant Death and Modulation of Late Sodium Current by Hypoxia, Investigated in Induced Pluripotent Stem Cells', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, Los Angeles, Vol. 110, pp. 30A - 30A, presented at 60th Annual Meeting of the Biophysical-Society, CA, Los Angeles, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.227

Mann SA; Vandenberg JI, 2014, 'Dynamic Action Potential Clamp Investigation of Pro-Arrhythmic Risk of Drugs Binding to hERG Potassium Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 106, pp. 553A - 553A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2013.11.3075

Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493

Olesen M; Liang B; Soka M; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Vandenberg JI; Svendsen JH; Haunso S; Preiss T; Seebohm G; Olesen S-P; Schmitt N; Fatkin D, 2013, 'TASK-1 potassium channel mutations in atrial fibrillation', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, NETHERLANDS, Amsterdam, Vol. 34, pp. 642 - 642, presented at Congress of the European-Society-of-Cardiology (ESC), NETHERLANDS, Amsterdam, 31 August 2013 - 04 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327744604084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

El-Ajouz S; Hill AP; Gulbis JM; Vandenberg JI, 2013, 'Understanding the Molecular Gates of KirBac3.1', in BIOPHYSICAL JOURNAL, CELL PRESS, PA, Philadelphia, Vol. 104, pp. 128A - 128A, presented at 57th Annual Meeting of the Biophysical-Society, PA, Philadelphia, 02 February 2013 - 06 February 2013, http://dx.doi.org/10.1016/j.bpj.2012.11.737

Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800

Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801

Ke Y; Hunter M; Ng CA; Vandenberg J, 2012, 'Domain Misfolding and Destabilisation of Domain–Domain Interactions Both Contribute to Defective Trafficking of hERG EAG Domain Mutant Channels', in Heart, Lung and Circulation, Vol. 21, pp. 860 - 861, http://dx.doi.org/10.1016/j.hlc.2012.08.025

Heide J; Mann SA; Vandenberg JI, 2010, 'CHARACTERIZATION OF A NOVEL HERG POTASSIUM CHANNEL ISOFORM UPREGULATED IN SCHIZOPHRENIA PATIENTS', in AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, INFORMA HEALTHCARE, Vol. 44, pp. A51 - A51, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282954700142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Szekely D; Dokos S; Vandenberg JI; Hill AP, 2010, 'An Improved Curvilinear Gradient Method for Parameter Estimation in Complex Model Systems: Application to Gating of A Cardiac Ion Channel', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 98, pp. 140A - 141A, http://dx.doi.org/10.1016/j.bpj.2009.12.758

Mann SA; Hill A; Vandenberg JI, 2009, 'Investigating Ion Channel Diseases With Dynamic Action Potential Clamp', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 96, pp. 259A - 259A, http://dx.doi.org/10.1016/j.bpj.2008.12.1279

Ju P; Torres A; Bansal PS; Vandenberg JI; Kuchel PW, 2007, 'Pore helix domain charged residues modulate inactivation of the hERG K+ channel', in Biophysical Journal, Biophysical Society, pp. 123A - 123A

Subbiah RN; Campbell TJ; Vandenberg JI, 2005, 'Tryptophan scanning mutagenesis suggests that the voltage sensor in HERG has a peripheral location', in Heart Rhythm, Vol. 2, pp. S106 - S107, http://www.sciencedirect.com/science/article/B7GW9-4GCD5P7-5/2/a4c7846becaa57ceeccffc5c4337c1ab

Subbiah RN; Clarke CE; Smith DG; Zhao J; Vandenberg JI; Campbell TJ, 2004, 'Alteration of voltage-dependence and activation kinetics of the HERGpotassium channel by mutations in the S4 sequence', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 541A - 541A

Clarke CE; Bursill JA; Zhao J; Wyse KR; Vandenberg JI, 2004, 'Sensitivity of human ether-a-go-go family channels to extracellulartetraethylammonium', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 278A - 278A

Saumarez RC; Vandenberg JI; Zinkin MP; Lowe MD; Taylor PJ; Ward DE; Camm AJ; Grace AA, 1997, 'Electrogram fractionation in the long QT syndrome and as modelled in perfused heart by inhibition of SCN5A-encoded ion channels', in Heart, Vol. 77

Phan K; Ng C; McNitt S; Moss A; Zareba W; Perry M; Vandenberg J, 'The role of in vitro phenotypes for clinical risk stratification of sudden death in Long QT Syndrome Type 2', in Heart, Lung and Circulation, Elsevier, Vol. 24, pp. S232 - S233, presented at Heart, Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2015.06.289

Datasets

Vandenberg J; Ng CA, 2016, Faculty Opinions recommendation of Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins., http://dx.doi.org/10.3410/f.727072588.793526218

Working Papers

Ma JG; O'Neill MJ; Richardson E; Thomson KL; Ingles J; Muhammad A; Solus JF; Davogustto G; Anderson KC; Benjamin Shoemaker M; Stergachis AB; Floyd BJ; Dunn K; Parikh VN; Chubb H; Perrin MJ; Roden DM; Vandenberg JI; Ng C-A; Glazer AM, 2023, Multi-site validation of a functional assay to adjudicate SCN5A Brugada Syndrome-associated variants., http://dx.doi.org10.1101/2023.12.19.23299592, https://www.ncbi.nlm.nih.gov/pubmed/38196587

Ballouz S; Mangala M; Perry M; Heitmann S; Gillis J; Hill A; Vandenberg J, 2019, Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events, http://dx.doi.org10.1101/659821

Beattie K; Hill A; Bardenet R; Cui Y; Vandenberg J; Gavaghan D; de Boer T; Mirams G, 2017, Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics, http://dx.doi.org10.1101/100677

Hodkinson EC; Hill AP; Vandenberg JI, 2014, The romano-ward syndrome 1964 2014: 50 years of progress, http://dx.doi.org

Preprints

O'Neill MJ; Ng C-A; Aizawa T; Sala L; Bains S; Winbo A; Ullah R; Shen Q; Tan C-Y; Kozek K; Vanags LR; Mitchell DW; Shen A; Wada Y; Kashiwa A; Crotti L; Dagradi F; Musu G; Spazzolini C; Neves R; Bos JM; Giudicessi JR; Bledsoe X; Gamazon ER; Lancaster M; Glazer AM; Knollmann BC; Roden DM; Weile J; Roth F; Salem J-E; Earle N; Stiles R; Agee T; Johnson CN; Horie M; Skinner J; Ackerman MJ; Schwartz PJ; Ohno S; Vandenberg JI; Kroncke BM, 2024, Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification., http://dx.doi.org/10.1101/2024.02.01.24301443

Heitmann S; Vandenberg J; Hill A, 2024, Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes, http://dx.doi.org/10.1101/2024.09.18.613631

Lau CHY; Flood E; Hunter MJ; Williams-Noonan BJ; Corbett KM; Ng C-A; Bouwer JC; Stewart AG; Perozo E; Allen TW; Vandenberg JI, 2023, Potassium dependent structural changes in the selectivity filter of HERG potassium channels, http://dx.doi.org/10.1101/2023.12.14.571769

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/eLife.90027

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/elife.90027.2

Heitmann S; Vandenberg JI; Hill AP, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.7554/elife.90027.1

Heitmann S; Vandenberg J; Hill A, 2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, http://dx.doi.org/10.1101/2023.04.19.537441

Thomson K; Jiang C; Richardson E; Westphal D; Burkard T; Wolf C; Vatta M; Harrison S; Ingles J; Bezzina C; Kroncke B; Vandenberg J; Ng C-A, 2023, Clinical interpretation ofKCNH2variants using a robust PS3/BS3 functional patch clamp assay, http://dx.doi.org/10.1101/2023.10.08.23296707

Thorpe J; Perry M; Contreras O; Hurley E; Parker G; Harvey R; Hill A; Vandenberg J, 2023, Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia, http://dx.doi.org/10.21203/rs.3.rs-2744099/v1

Lim S; Mangala M; Holliday M; Szappanos HC; Ross S; Liang W; Ranpura G; Vandenberg J; Semsarian C; Hill A; Hool L, 2023, Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy, http://dx.doi.org/10.1101/2023.07.20.549952

Copier JS; Bootsma M; Ng C; Wilde AAM; Bertels RA; Bikker H; Christiaans I; van der Crabben SN; Hol JA; Koopmann TT; Knijnenburg J; Lommerse AAJ; van der Smagt JJ; Bezzina CR; Vandenberg JI; Verkerk AO; Barge-Schaapveld DQCM; Lodder EM, 2022, Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance, http://dx.doi.org/10.1101/2022.08.05.502917

Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C-A, 2021, A calibrated functional patch clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome, http://dx.doi.org/10.1101/2021.12.13.472492

Vandenberg J; Lau C; Flood E; Hunter M; Ng C-A; Bouwer J; Stewart A; Perozo E; Allen T, 2021, Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels, http://dx.doi.org/10.21203/rs.3.rs-1105661/v1

Kozek KA; Glazer AM; Ng C-A; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg J; Roden DM; Kroncke BM, 2020, High-throughput discovery of trafficking-deficient variants in the cardiac potassium channelKCNH2: Deep mutational scan ofKCNH2trafficking, http://dx.doi.org/10.1101/2020.02.17.952606

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, Protocol-dependent differences in IC₅₀ values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding, http://dx.doi.org/10.1101/534867

Windley MJ; Farr J; Vandenberg JI; Hill AP, Translating the Measurement of Herg Kinetics and Drug Block for Cipa to a High Throughput Platform, http://dx.doi.org/10.2139/ssrn.4065593

Other

Ng C-A; Ullah R; Farr J; Hill A; Kozek K; Vanags L; Mitchell D; Kroncke B; Vandenberg J, 2021, A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function inKCNH2Variants, http://dx.doi.org/10.1101/2021.07.10.451881

Vandenberg JI; Hill AP, 2016, An 'alternans' way to quantify arrhythmogenic substrates, http://dx.doi.org/10.1113/JP271838

Martinac B; Vandenberg J, 2015, 'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics, http://dx.doi.org/10.1113/jphysiol.2014.286559

Vandenberg JI, 2010, Oxidative stress fine-tunes the dance of hERG K+ channels, Blackwell Publishing Ltd, http://dx.doi.org/10.1113/jphysiol.2010.195651

Vandenberg JI; Hill AP; Campbell TJ; Clarke CE, 2006, Reply from Jamie I. Vandenberg, Adam P. Hill, Terence J. Campbell, Catherine E. Clarke [2], http://dx.doi.org/10.1113/jphysiol.2006.577102

Subbiah RN; Campbell TJ; Vandenberg JI, 2005, Erratum: Inherited cardiac arrhythmia syndromes: What have they taught us about arrhythmias and anti-arrhythmic therapy? (Clinical and Experimental Pharmacology and Physiology (2004) 31 (906-912))

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