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Select Publications
2007, 'Pore helix domain charged residues modulate inactivation of the hERG K+ channel', in Biophysical Journal, Biophysical Society, Baltimore, MD, pp. 123A - 123A, presented at 51st Annual Meeting of the Biophysical-Society, Baltimore, MD, 03 - 07 March 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243972400567&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
,2005, 'Tryptophan scanning mutagenesis suggests that the voltage sensor in HERG has a peripheral location', in Heart Rhythm, Vol. 2, pp. S106 - S107, http://www.sciencedirect.com/science/article/B7GW9-4GCD5P7-5/2/a4c7846becaa57ceeccffc5c4337c1ab
,2004, 'Alteration of voltage-dependence and activation kinetics of the HERGpotassium channel by mutations in the S4 sequence', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 541A - 541A
,2004, 'Sensitivity of human ether-a-go-go family channels to extracellulartetraethylammonium', in Biophysical Journal, Biophysical Society, Vol. 86, pp. 278A - 278A
,1997, 'Electrogram fractionation in the long QT syndrome and as modelled in perfused heart by inhibition of SCN5A-encoded ion channels', in Heart, Vol. 77
,'The role of in vitro phenotypes for clinical risk stratification of sudden death in Long QT Syndrome Type 2', in Heart, Lung and Circulation, Elsevier, Vol. 24, pp. S232 - S233, presented at Heart, Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2015.06.289
,2016, Faculty Opinions recommendation of Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins., , http://dx.doi.org/10.3410/f.727072588.793526218
,2023, Multi-site validation of a functional assay to adjudicate SCN5A Brugada Syndrome-associated variants., http://dx.doi.org10.1101/2023.12.19.23299592, https://www.ncbi.nlm.nih.gov/pubmed/38196587
,2019, Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events, http://dx.doi.org10.1101/659821
,2017, Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics, http://dx.doi.org10.1101/100677
,2014, The romano-ward syndrome 1964 2014: 50 years of progress, http://dx.doi.org
,2024, Multiplexed Assays of Variant Effect and Automated Patch-clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification., , http://dx.doi.org/10.1101/2024.02.01.24301443
,2023, Potassium dependent structural changes in the selectivity filter of HERG potassium channels, , http://dx.doi.org/10.1101/2023.12.14.571769
,2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, , http://dx.doi.org/10.7554/elife.90027.2
,2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, , http://dx.doi.org/10.7554/elife.90027.1
,2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, , http://dx.doi.org/10.7554/eLife.90027
,2023, Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology, , http://dx.doi.org/10.1101/2023.04.19.537441
,2023, Clinical interpretation ofKCNH2variants using a robust PS3/BS3 functional patch clamp assay, , http://dx.doi.org/10.1101/2023.10.08.23296707
,2023, Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia, , http://dx.doi.org/10.21203/rs.3.rs-2744099/v1
,2023, Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy, , http://dx.doi.org/10.1101/2023.07.20.549952
,2022, Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance, , http://dx.doi.org/10.1101/2022.08.05.502917
,2021, A calibrated functional patch clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome, , http://dx.doi.org/10.1101/2021.12.13.472492
,2021, Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels, , http://dx.doi.org/10.21203/rs.3.rs-1105661/v1
,2020, High-throughput discovery of trafficking-deficient variants in the cardiac potassium channelKCNH2: Deep mutational scan ofKCNH2trafficking, , http://dx.doi.org/10.1101/2020.02.17.952606
,2019, Protocol-dependent differences in IC50 values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding, , http://dx.doi.org/10.1101/534867
,Translating the Measurement of Herg Kinetics and Drug Block for Cipa to a High Throughput Platform, , http://dx.doi.org/10.2139/ssrn.4065593
,2021, A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function inKCNH2Variants, , http://dx.doi.org/10.1101/2021.07.10.451881
,2016, An 'alternans' way to quantify arrhythmogenic substrates, , http://dx.doi.org/10.1113/JP271838
,2015, 'Shooting gallery' for membrane proteins provides new insights into complexities of their function and structural dynamics, , http://dx.doi.org/10.1113/jphysiol.2014.286559
,2010, Oxidative stress fine-tunes the dance of hERG K+ channels, Blackwell Publishing Ltd, , http://dx.doi.org/10.1113/jphysiol.2010.195651
,2006, Reply from Jamie I. Vandenberg, Adam P. Hill, Terence J. Campbell, Catherine E. Clarke [2], , http://dx.doi.org/10.1113/jphysiol.2006.577102
,2005, Erratum: Inherited cardiac arrhythmia syndromes: What have they taught us about arrhythmias and anti-arrhythmic therapy? (Clinical and Experimental Pharmacology and Physiology (2004) 31 (906-912)),
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