Select Publications
Journal articles
2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006
,2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805
,2016, 'Temperature effects on kinetics of K
2016, 'Heritability of ECG biomarkers in the Netherlands twin registry measured from Holter ECGs', Frontiers in Physiology, 7, http://dx.doi.org/10.3389/fphys.2016.00154
,2016, 'A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm', Journal of Biomolecular Screening, 21, pp. 1 - 11, http://dx.doi.org/10.1177/1087057115594589
,2016, 'Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status', American Journal of Psychiatry, 173, pp. 53 - 59, http://dx.doi.org/10.1176/appi.ajp.2015.14050653
,2016, 'In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS', Progress in Biophysics and Molecular Biology, 120, pp. 89 - 99, http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.005
,2016, 'TECRL: Connecting sequence to consequence for a new sudden cardiac death gene', EMBO Molecular Medicine, 8, pp. 1364 - 1365, http://dx.doi.org/10.15252/emmm.201606967
,2016, 'T Wave Morphology Can Distinguish Healthy Controls From LQTS Patients With Normal QT Intervals', Heart, Lung and Circulation, 25, pp. S262 - S262, http://dx.doi.org/10.1016/j.hlc.2016.06.610
,2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275
,2015, 'Expression of KCNH2-3.1 mRNA is increased in small neurons in the dorsolateral prefrontal cortex in patients with schizophrenia', European Journal of Psychiatry, 29, pp. 85 - 103, http://dx.doi.org/10.4321/S0213-61632015000200001
,2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095
,2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568
,2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379
,2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277
,2014, 'Kinetics of drug interaction with the K
2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms6069
,2014, 'The Romano-Ward syndrome--1964-2014: 50 years of progress.', Irish medical journal, 107, pp. 122 - 124
,2013, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.', J Mol Cell Cardiol, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014
,2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, 8, pp. e77032, http://dx.doi.org/10.1371/journal.pone.0077032
,2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975
,2013, 'Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram', Journal of Physiology, 591, pp. 4207 - 4222, http://dx.doi.org/10.1113/jphysiol.2013.251710
,2013, 'Trafficking defects in PAS domain mutant Kv11.1 channels: Roles of reduced domain stability and altered domain-domain interactions', Biochemical Journal, 454, pp. 69 - 77, http://dx.doi.org/10.1042/BJ20130328
,2013, 'TASK-1 potassium channel mutations in atrial fibrillation', European Heart Journal, 34, pp. 3411 - 3411, http://dx.doi.org/10.1093/eurheartj/eht309.3411
,2013, 'A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death', Journal of Molecular and Cellular Cardiology, 61, pp. 123 - 132, http://dx.doi.org/10.1016/j.yjmcc.2013.06.005
,2013, '2SDP-03 Ion channel gating and Japanese Puzzle Boxes(2SDP ASB-BSJ Bilateral Symposium 2013,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)', Seibutsu Butsuri, 53, pp. S99 - S99, http://dx.doi.org/10.2142/biophys.53.s99_3
,2013, 'A Transgenic Zebrafish Model of a Human Cardiac Sodium Channel Mutation Exhibits Bradycardia, Conduction-System Abnormalities and Early Death', Heart, Lung and Circulation, 22, pp. S227 - S227, http://dx.doi.org/10.1016/j.hlc.2013.05.539
,2013, 'Epistatic Interactions of Ion Channels Underlie Variability in Cardiac Electrical Activity. In-silico Analysis of the Electrocardiogram', Heart, Lung and Circulation, 22, pp. S95 - S96, http://dx.doi.org/10.1016/j.hlc.2013.05.226
,2012, 'Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk', Journal of the American College of Cardiology, 59, pp. 1017 - 1025, http://dx.doi.org/10.1016/j.jacc.2011.11.039
,2012, 'hERG K+ CHANNELS: STRUCTURE, FUNCTION, AND CLINICAL SIGNIFICANCE', Physiological Reviews, 92, pp. 1393 - 1478, http://dx.doi.org/10.1152/physrev.00036.2011
,2012, 'Hodgkin and Huxley and the basis for electrical signalling: a remarkable legacy still going strong', The Journal of Physiology, 590, pp. 2569 - 2570, http://dx.doi.org/10.1113/jphysiol.2012.233411
,2012, 'Insights into hERG K+ channel structure and function from NMR studies', European Biophysics Journal With Biophysics Letters, 42, pp. 71 - 79, http://dx.doi.org/10.1007/s00249-012-0808-6
,2012, 'Is medroxyprogesterone safe in women with long QT syndrome?', Heart Rhythm, 9, pp. 1148 - 1149, http://dx.doi.org/10.1016/j.hrthm.2012.02.029
,2012, 'R222Q SCN5A Mutation Is Associated With Reversible Ventricular Ectopy and Dilated Cardiomyopathy', Journal of the American College of Cardiology, 60, pp. 1566 - 1573, http://dx.doi.org/10.1016/j.jacc.2012.05.050
,2012, 'The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating', PLoS ONE, 7, pp. e31640, http://dx.doi.org/10.1371/journal.pone.0031640
,2012, 'The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations', PLoS ONE, 7, pp. e45624, http://dx.doi.org/10.1371/journal.pone.0045624
,2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761
,2011, 'An improved curvilinear gradient method for parameter optimization in complex biological models', Medical and Biological Engineering and Computing, 49, pp. 289 - 296, http://dx.doi.org/10.1007/s11517-010-0667-1
,2011, 'The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation', PLoS One, 6, pp. e16191, http://dx.doi.org/10.1371/journal.pone.0016191
,2010, 'Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels', Cell, 141, pp. 1018 - 1029, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20564790
,2010, 'Mapping the sequence of conformational changes underlying selectivity filter gating in the K(v)11.1 potassium channel', Nature Structural and Molecular Biology, 18, pp. 35 - 41, http://dx.doi.org/10.1038/nsmb.1966
,2009, 'Insight into Accurate Testing of Drugs which Cause the Acquired Long-QT Syndrome', Heart, Lung and Circulation, 18, pp. S135 - S135, http://dx.doi.org/10.1016/j.hlc.2009.05.306
,2009, 'Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype', Journal of Cardiovascular Electrophysiology, 20, pp. 923 - 930, http://dx.doi.org/10.1111/j.1540-8167.2009.01468.x
,2009, 'Structure of the pore-helix of the hERG K(+) channel', European Biophysics Journal, 39, pp. 111 - 120, http://dx.doi.org/10.1007/s00249-009-0433-1
,2009, 'The pore domain outer helix contributes to both activation and inactivation of the hERG K+ channel', The Journal of Biological Chemistry, 284, pp. 1000 - 1006, http://dx.doi.org/10.1074/jbc.M806400200
,2008, 'Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels', Molecular Pharmacology, 74, pp. 1443 - 1452
,2008, 'Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction', Progress in Biophysics and Molecular Biology, 98, pp. 137 - 148
,2008, 'Substrate specificity of platypus venom L-to-D-peptide isomerase', The Journal of Biological Chemistry, 283, pp. 8969 - 8975, http://dx.doi.org/10.1074/jbc.M709762200
,2008, 'The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function', The Journal of Biological Chemistry, 283, pp. 16985 - 16992, http://dx.doi.org/10.1074/jbc.M801368200
,2007, 'Atrial Fibrillation-A New Cardiac Channelopathy', Heart Lung and Circulation, 16, pp. 356 - 360, http://dx.doi.org/10.1016/j.hlc.2007.07.003
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