By Professor Jamie Vandenberg

Journal articles

TeBay C; McArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hill AP, 2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, 179, pp. 2631 - 2646, http://dx.doi.org/10.1111/bph.15757

Kerr NP; Vandenberg JI, 2022, 'The yin and yang of Tbx5 variant effects on sodium channel function', Cardiovascular Research, 118, pp. 929 - 931, http://dx.doi.org/10.1093/cvr/cvac015

Peters S; Thompson BA; Perrin M; James P; Zentner D; Kalman JM; Vandenberg JI; Fatkin D, 2022, 'Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review', Circulation Genomic and Precision Medicine, 15, pp. E003432, http://dx.doi.org/10.1161/CIRCGEN.121.003432

Ng CA; Vandenberg JI, 2022, 'When it takes two to get one into trouble', Heart Rhythm, 19, pp. 293 - 294, http://dx.doi.org/10.1016/j.hrthm.2021.10.017

Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280

Heitmann S; Shpak A; Vandenberg JI; Hill AP, 2021, 'Arrhythmogenic effects of ultra-long and bistable cardiac action potentials', Plos Computational Biology, 17, pp. e1008683, http://dx.doi.org/10.1371/JOURNAL.PCBI.1008683

Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, 6, pp. 1 - 9, http://dx.doi.org/10.1093/biomethods/bpab003

Kozek KA; Glazer AM; Ng CA; Blackwell D; Egly CL; Vanags LR; Blair M; Mitchell D; Matreyek KA; Fowler DM; Knollmann BC; Vandenberg JI; Roden DM; Kroncke BM, 2020, 'High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1', Heart Rhythm, 17, pp. 2180 - 2189, http://dx.doi.org/10.1016/j.hrthm.2020.05.041

Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247

Ganesan AN; Vanoye CG; Alam F; Waddell-Smith KE; McGavigan AD; Correnti G; Haan E; Brown A; Vandenberg J; George AL, 2020, 'Long QT syndrome type 1 in an Australian indigenous patient', Circulation Genomic and Precision Medicine, 13, pp. 93 - 94, http://dx.doi.org/10.1161/CIRCGEN.119.002813

Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020

Li Z; Mirams GR; Yoshinaga T; Ridder BJ; Han X; Chen JE; Stockbridge NL; Wisialowski TA; Damiano B; Severi S; Morissette P; Kowey PR; Holbrook M; Smith G; Rasmusson RL; Liu M; Song Z; Qu Z; Leishman DJ; Steidl-Nichols J; Rodriguez B; Bueno-Orovio A; Zhou X; Passini E; Edwards AG; Morotti S; Ni H; Grandi E; Clancy CE; Vandenberg J; Hill A; Nakamura M; Singer T; Polonchuk L; Greiter-Wilke A; Wang K; Nave S; Fullerton A; Sobie EA; Paci M; Musuamba Tshinanu F; Strauss DG, 2020, 'General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy', Clinical Pharmacology and Therapeutics, 107, pp. 102 - 111, http://dx.doi.org/10.1002/cpt.1647

Munawar S; Vandenberg JI; Jabeen I, 2019, 'Molecular docking guided grid-independent descriptor analysis to probe the impact ofwater molecules on conformational changes of hERG inhibitors in drug trapping phenomenon', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20143385

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220

Tardo D; Peck M; Hill A; Vandenberg J, 2019, 'T Wave Morphology Biomarkers in Congenital and Acquired Long QT Syndrome', Heart, Lung and Circulation, 28, pp. S229 - S229, http://dx.doi.org/10.1016/j.hlc.2019.06.223

Munawar S; Windley MJ; Tse EG; Todd MH; Hill AP; Vandenberg JI; Jabeen I, 2018, 'Experimentally validated pharmacoinformatics approach to predict hERG inhibition potential of new chemical entities', Frontiers in Pharmacology, 9, pp. 1035, http://dx.doi.org/10.3389/fphar.2018.01035

Beattie KA; Hill AP; Bardenet R; Cui Y; Vandenberg JI; Gavaghan DJ; de Boer TP; Mirams GR, 2018, 'Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics', Journal of Physiology, 596, pp. 1813 - 1828, http://dx.doi.org/10.1113/JP275733

Lau C; Hunter MJ; Stewart A; Perozo E; Vandenberg JI, 2018, 'Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy', Journal of Physiology, 596, pp. 1107 - 1119, http://dx.doi.org/10.1113/JP274888

Windley MJ; Lee W; Vandenberg JI; Hill AP, 2018, 'The temperature dependence of kinetics associated with drug block of hERG channels is compound-specific and an important factor for proarrhythmic risk prediction', Molecular Pharmacology, 94, pp. 760 - 769, http://dx.doi.org/10.1124/mol.117.111534

Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309

Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039

Lee W; Windley MJ; Vandenberg JI; Hill AP, 2017, 'In vitro and in silico risk assessment in acquired long QT syndrome: The devil is in the details', Frontiers in Physiology, 8, pp. 934, http://dx.doi.org/10.3389/fphys.2017.00934

Vandenberg JI; Perozo E; Allen TW, 2017, 'Towards a Structural View of Drug Binding to hERG K+ Channels', Trends in Pharmacological Sciences, 38, pp. 899 - 907, http://dx.doi.org/10.1016/j.tips.2017.06.004

Windley MJ; Abi-Gerges N; Fermini B; Hancox JC; Vandenberg JI; Hill AP, 2017, 'Measuring kinetics and potency of hERG block for CiPA', Journal of Pharmacological and Toxicological Methods, 87, pp. 99 - 107, http://dx.doi.org/10.1016/j.vascn.2017.02.017

Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298

Grandi E; Sanguinetti MC; Bartos DC; Bers DM; Chen-Izu Y; Chiamvimonvat N; Colecraft HM; Delisle BP; Heijman J; Navedo MF; Noskov S; Proenza C; Vandenberg JI; Yarov-Yarovoy V, 2017, 'Potassium channels in the heart: structure, function and regulation', Journal of Physiology, 595, pp. 2209 - 2228, http://dx.doi.org/10.1113/JP272864

Chiamvimonvat N; Chen-Izu Y; Clancy CE; Deschenes I; Dobrev D; Heijman J; Izu L; Qu Z; Ripplinger CM; Vandenberg JI; Weiss JN; Koren G; Banyasz T; Grandi E; Sanguinetti MC; Bers DM; Nerbonne JM, 2017, 'Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics', Journal of Physiology, 595, pp. 2229 - 2252, http://dx.doi.org/10.1113/JP272883

Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000research, 6, http://dx.doi.org/10.12688/f1000research.11855.1

Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015

Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011

Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392

Immanuel SA; Sadrieh A; Baumert M; Couderc JP; Zareba W; Hill AP; Vandenberg JI, 2016, 'T-wave morphology can distinguish healthy controls from LQTS patients', Physiological Measurement, 37, pp. 1456 - 1473, http://dx.doi.org/10.1088/0967-3334/37/9/1456

Christensen AH; Chatelain FC; Huttner IG; Olesen MS; Soka M; Feliciangeli S; Horvat C; Santiago CF; Vandenberg JI; Schmitt N; Olesen SP; Lesage F; Fatkin D, 2016, 'The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size', Journal of Molecular and Cellular Cardiology, 97, pp. 24 - 35, http://dx.doi.org/10.1016/j.yjmcc.2016.04.006

Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805

Windley MJ; Mann SA; Vandenberg JI; Hill AP, 2016, 'Temperature effects on kinetics of KV11.1 drug block have important consequences for in silico proarrhythmic risk prediction', Molecular Pharmacology, 90, pp. 1 - 11, http://dx.doi.org/10.1124/mol.115.103127

Hodkinson EC; Neijts M; Sadrieh A; Imtiaz MS; Baumert M; Subbiah RN; Hayward CS; Boomsma D; Willemsen G; Vandenberg JI; Hill AP; De Geus E, 2016, 'Heritability of ECG biomarkers in the Netherlands twin registry measured from Holter ECGs', Frontiers in Physiology, 7, http://dx.doi.org/10.3389/fphys.2016.00154

Fermini B; Hancox JC; Abi-Gerges N; Bridgland-Taylor M; Chaudhary KW; Colatsky T; Correll K; Crumb W; Damiano B; Erdemli G; Gintant G; Imredy J; Koerner J; Kramer J; Levesque P; Li Z; Lindqvist A; Obejero-Paz CA; Rampe D; Sawada K; Strauss DG; Vandenberg JI, 2016, 'A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm', Journal of Biomolecular Screening, 21, pp. 1 - 11, http://dx.doi.org/10.1177/1087057115594589

Lee W; Mann SA; Windley MJ; Imtiaz MS; Vandenberg JI; Hill AP, 2016, 'In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS', Progress in Biophysics and Molecular Biology, 120, pp. 89 - 99, http://dx.doi.org/10.1016/j.pbiomolbio.2015.12.005

Perry MD; Vandenberg JI, 2016, 'TECRL: Connecting sequence to consequence for a new sudden cardiac death gene', EMBO Molecular Medicine, 8, pp. 1364 - 1365, http://dx.doi.org/10.15252/emmm.201606967

Heide J; Zhang F; Bigos KL; Mann SA; Carr VJ; Shannon Weickert C; Green MJ; Weinberger DR; Vandenberg JI, 2016, 'Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status.', Am J Psychiatry, 173, pp. 53 - 59, http://dx.doi.org/10.1176/appi.ajp.2015.14050653

Immanuel S; Sadrieh A; Baumert M; Couderc J; Zareba W; Hill A; Vandenberg J, 2016, 'T Wave Morphology Can Distinguish Healthy Controls From LQTS Patients With Normal QT Intervals', Heart, Lung and Circulation, 25, pp. S262 - S262, http://dx.doi.org/10.1016/j.hlc.2016.06.610

Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275

Heide J; Vandenberg JI; Weickert CS, 2015, 'Expression of KCNH2-3.1 mRNA is increased in small neurons in the dorsolateral prefrontal cortex in patients with schizophrenia', European Journal of Psychiatry, 29, pp. 85 - 103, http://dx.doi.org/10.4321/S0213-61632015000200001

Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K+ channel gating', Journal of Physiology, 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095

Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568

Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379

Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277

Liang B; Soka M; Christensen AH; Olesen MS; Larsen AP; Knop FK; Wang F; Nielsen JB; Andersen MN; Humphreys D; Mann SA; Huttner IG; Vandenberg JI; Svendsen JH; Haunsø S; Preiss T; Seebohm G; Olesen SP; Schmitt N; Fatkin D, 2014, 'Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis', Journal of Molecular and Cellular Cardiology, 67, pp. 69 - 76, http://dx.doi.org/10.1016/j.yjmcc.2013.12.014

Hill AP; Perrin MJ; Heide J; Campbell TJ; Mann SA; Vandenberg JI, 2014, 'Kinetics of drug interaction with the Kv11.1 potassium channel', Molecular Pharmacology, 85, pp. 769 - 776, http://dx.doi.org/10.1124/mol.114.091835

Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms6069

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