By Professor Christopher Carl Goodnow

Journal articles

Townsend SE; Goodnow CC, 1996, 'T cell/B cell collaboration in the lysozyme system: An in vivo model', FASEB Journal, 10

Rathmell JC; Townsend SE; Xu JC; Flavell RA; Goodnow CC, 1996, 'Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor', Cell, 87, pp. 319 - 329, http://dx.doi.org/10.1016/S0092-8674(00)81349-5

Cyster JG; Healy JI; Kishihara K; Mak TW; Thomas ML; Goodnow CC, 1996, 'Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45', Nature, 381, pp. 325 - 328, http://dx.doi.org/10.1038/381325a0

Liblau RS; Tisch R; Shokat K; Yang XD; Dumont N; Goodnow CC; Mcdevitt HO, 1996, 'Intravenous injection of soluble antigen induces thymic and peripheral T-cell apoptosis', Proceedings of the National Academy of Sciences of the United States of America, 93, pp. 3031 - 3036, http://dx.doi.org/10.1073/pnas.93.7.3031

Goodnow CC, 1996, 'Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires', Proceedings of the National Academy of Sciences of the United States of America, 93, pp. 2264 - 2271, http://dx.doi.org/10.1073/pnas.93.6.2264

Dempsey PW; Allison MED; Akkaraju S; Goodnow CC; Fearon DT, 1996, 'C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity', Science, 271, pp. 348 - 350, http://dx.doi.org/10.1126/science.271.5247.348

Janeway CA; Goodnow CC; Medzhitov R, 1996, 'Immunological tolerance: Danger - Pathogen on the premises!', Current Biology, 6, pp. 519 - 522, http://dx.doi.org/10.1016/s0960-9822(02)00531-6

Cyster JG; Goodnow CC, 1995, 'Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords', Journal of Experimental Medicine, 182, pp. 581 - 586, http://dx.doi.org/10.1084/jem.182.2.581

Rathmell JC; Cooke MP; Ho WY; Grein J; Townsend SE; Davis MM; Goodnow CC, 1995, 'CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4⁺T cells', Nature, 376, pp. 181 - 184, http://dx.doi.org/10.1038/376181a0

Shokat KM; Goodnow CC, 1995, 'Antigen-induced B-cell death and elimination during germinal-centre immune responses', Nature, 375, pp. 334 - 338, http://dx.doi.org/10.1038/375334a0

Cyster JG; Goodnow CC, 1995, 'Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate', Immunity, 3, pp. 691 - 701, http://dx.doi.org/10.1016/1074-7613(95)90059-4

Rathmell JC; Goodnow CC, 1995, 'Autoimmunity: The Fas track', Current Biology, 5, pp. 1218 - 1221, http://dx.doi.org/10.1016/S0960-9822(95)00241-7

Brink R; Goodnow CC; Basten A, 1995, 'IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up‐regulation CD80/CD86 co‐stimulatory molecules', European Journal of Immunology, 25, pp. 1980 - 1984, http://dx.doi.org/10.1002/eji.1830250727

Cyster JG; Goodnow CC, 1995, 'Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection', Immunity, 2, pp. 13 - 24, http://dx.doi.org/10.1016/1074-7613(95)90075-6

Goodnow CC; Cyster JG; Hartley SB; Bell SE; Cooke MP; Healy JI; Akkaraju S; Rathmell JC; Pogue SL; Shokat KP, 1995, 'Self-tolerance checkpoints in B lymphocyte development', Advances in Immunology, 59, pp. 279 - 368, http://dx.doi.org/10.1016/s0065-2776(08)60633-1

Lund FE; Solvason NW; Cooke MP; Heath AW; Grimaldi JC; Parkhouse RME; Goodnow CC; Howard MC, 1995, 'Signaling through murine CD38 is impaired in antigen receptor‐unresponsive B cells', European Journal of Immunology, 25, pp. 1338 - 1345, http://dx.doi.org/10.1002/eji.1830250531

Cornall RJ; Goodnow CC; Cyster JG, 1995, 'The regulation of self-reactive B cells', Current Opinion in Immunology, 7, pp. 804 - 811, http://dx.doi.org/10.1016/0952-7915(95)80052-2

Brink R; Fulcher DA; Goodnow CC; Basten A, 1994, 'Differential regulation of early and late stages of B lymphocyte development by the μ and δ membrane heavy chains of Ig', International Immunology, 6, pp. 1905 - 1916, http://dx.doi.org/10.1093/intimm/6.12.1905

Rathmell JC; Goodnow CC, 1994, 'Effects of the lpr mutation on elimination and inactivation of self-reactive B cells', Journal of Immunology, 153, pp. 2831 - 2842

Hartley SB; Goodnow CC, 1994, 'Censoring of self-reactive b cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody', International Immunology, 6, pp. 1417 - 1425, http://dx.doi.org/10.1093/intimm/6.9.1417

Lenschow DJ; Sperling AI; Cooke MP; Freeman G; Rhee L; Decker DC; Gray G; Nadler LM; Goodnow CC; Bluestone JA, 1994, 'Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen', Journal of Immunology, 153, pp. 1990 - 1997

Ho WY; Cooke MP; Goodnow CC; Davis MM, 1994, 'Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4⁺ T cells', Journal of Experimental Medicine, 179, pp. 1539 - 1549, http://dx.doi.org/10.1084/jem.179.5.1539

Pogue SL; Goodnow CC, 1994, 'Ig heavy chain extracellular spacer confers unique glycosylation of the Mb-1 component of the B cell antigen receptor complex', Journal of Immunology, 152, pp. 3925 - 3934

Bell SE; Goodnow CC, 1994, 'A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes', EMBO Journal, 13, pp. 816 - 826, http://dx.doi.org/10.1002/j.1460-2075.1994.tb06324.x

Cooke MP; Heath AW; Shokat KM; Zeng Y; Finkelman FD; Linsley PS; Howard M; Goodnow CC, 1994, 'Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells', Journal of Experimental Medicine, 179, pp. 425 - 438, http://dx.doi.org/10.1084/jem.179.2.425

Cyster JG; Hartley SB; Goodnow CC, 1994, 'Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire', Nature, 371, pp. 389 - 395, http://dx.doi.org/10.1038/371389a0

Hartley SB; Cooke MP; Fulcher DA; Harris AW; Cory S; Basten A; Goodnow CC, 1993, 'Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death', Cell, 72, pp. 325 - 335, http://dx.doi.org/10.1016/0092-8674(93)90111-3

Nossal GJV; Herold KC; Goodnow CC, 1992, 'Autoimmune tolerance and Type 1 (insulin-dependent) diabetes mellitus', Diabetologia, 35, http://dx.doi.org/10.1007/BF00586279

Brink R; Goodnow CC; Crosbie J; Adams E; Ens J; Mason DY; Hartley SB; Basten A, 1992, 'Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen', Journal of Experimental Medicine, 176, pp. 991 - 1005

MASON DY; JONES M; GOODNOW CC, 1992, 'DEVELOPMENT AND FOLLICULAR LOCALIZATION OF TOLERANT LYMPHOCYTES-B IN LYSOZYME ANTILYSOZYME IGM IGD TRANSGENIC MICE', INTERNATIONAL IMMUNOLOGY, 4, pp. 163 - 175, http://dx.doi.org/10.1093/intimm/4.2.163

Goodnow CC, 1992, 'B-cell tolerance', Current Opinion in Immunology, 4, pp. 703 - 710, http://dx.doi.org/10.1016/0952-7915(92)90049-K

Goodnow CC, 1992, 'Safe havens for self-reactive cells', Current Biology, 2, pp. 417 - 419, http://dx.doi.org/10.1016/0960-9822(92)90321-Z

Goodnow CC, 1992, 'Transgenic mice and analysis of B-cell tolerance', Annual Review of Immunology, 10, pp. 489 - 518, http://dx.doi.org/10.1146/annurev.iy.10.040192.002421

Adelstein S; Pritchard-Briscoe H; Anderson TA; Crosbie J; Gammon G; Loblay RH; Basten A; Goodnow CC, 1991, 'Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen', Science, 251, pp. 1223 - 1225

Goodnow CC; Brink R; Adams E, 1991, 'Breakdown of self-tolerance in anergic B lymphocytes', Nature, 352, pp. 532 - 536, http://dx.doi.org/10.1038/352532a0

Brooks A; Hartley S; Kjer-Nielsen L; Perera J; Goodnow CC; Basten A; McCluskey J, 1991, 'Class II-restricted presentation of an endogenously derived immunodominant T-cell determinant of hen egg lysozyme', Proceedings of the National Academy of Sciences of the United States of America, 88, pp. 3290 - 3294, http://dx.doi.org/10.1073/pnas.88.8.3290

Hartley SB; Crosbie J; Brink R; Kantor AB; Basten A; Goodnow CC, 1991, 'Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens', Nature, 353, pp. 765 - 769, http://dx.doi.org/10.1038/353765a0

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self tolerance in the B-cell repertoire', Immunological Reviews

Basten A; Brink R; Peake P; Adams E; Crosbie J; Hartley S; Goodnow CC, 1991, 'Self Tolerance in the B‐Cell Repertoire', Immunological Reviews, 122, pp. 5 - 19, http://dx.doi.org/10.1111/j.1600-065X.1991.tb00593.x

Adams E; Basten A; Goodnow CC, 1990, 'Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice', Proceedings of the National Academy of Sciences of the United States of America, 87, pp. 5687 - 5691, http://dx.doi.org/10.1073/pnas.87.15.5687

Goodnow CC; Adelstein S; Basten A, 1990, 'The need for central and peripheral tolerance in the B cell repertoire', Science, 248, pp. 1373 - 1379, http://dx.doi.org/10.1126/science.2356469

Goodnow CC, 1989, 'Cellular mechanisms of self-tolerance', Current Opinion in Immunology, 2, pp. 226 - 236, http://dx.doi.org/10.1016/0952-7915(89)90192-1

GOODNOW CC; CROSBIE J; ADELSTEIN S; LAVOIE TB; SMITHGILL SJ; MASON DY; JORGENSEN H; BRINK RA; PRITCHARDBRISCOE H; LOUGHNAN M; LOBLAY RH; TRENT RJ; BASTEN A, 1989, 'CLONAL SILENCING OF SELF-REACTIVE LYMPHOCYTES-B IN A TRANSGENIC MOUSE MODEL', COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 54, pp. 907 - 920, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1989JX74600035&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Goodnow CC; Crosbie J; Jorgensen H; Brink RA; Basten A, 1989, 'Induction of self-tolerance in mature peripheral B lymphocytes', Nature, 342, pp. 385 - 391, http://dx.doi.org/10.1038/342385a0

Goodnow CC; Basten A, 1989, 'Self-tolerance in B lymphocytes.', Seminars in immunology, 1, pp. 125 - 135

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 1988, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice', Nature, 334, pp. 676 - 682, http://dx.doi.org/10.1038/334676a0

Berg LJ; Fazekas de B; Ivars F; Goodnow CC; Gilfillan S; Garchon HJ; Davis MM, 1988, 'Expression of T-cell receptor alpha-chain genes in transgenic mice', Molecular and Cellular Biology, 8, pp. 5459 - 5469, http://dx.doi.org/10.1128/MCB.8.12.5459

Gascoigne NRJ; Goodnow CC; Dudzik KI; Davis MM, 1987, 'Secretion of a chimeric T-cell receptor-immunoglobulin protein', Proceedings of the National Academy of Sciences of the United States of America, 84, pp. 2936 - 2940, http://dx.doi.org/10.1073/pnas.84.9.2936

Davis MM; Gascoigne NR; Lindsten T; Goodnow C; Chien Y, 1987, 'Murine T-cell receptor genes.', Advances in experimental medicine and biology, 213, pp. 13 - 17, http://dx.doi.org/10.1007/978-1-4684-5323-2_2

Davis MM; Lindsten T; Gascoigne NR; Goodnow C; Chien YH, 1986, 'Paradigm regained: similarities and differences between T cell receptor and immunoglobulin genes.', Biochemical Society Symposia, 51, pp. 205 - 209

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