Select Publications
Books
2007, Chair's Introduction, http://dx.doi.org/10.1002/9780470062128.ch1
,2005, Connecting mammalian genome with phenome by ENU mouse mutagenesis: Gene combinations specifying the immune system, http://dx.doi.org/10.1146/annurev.genet.39.110304.095817
,1999, Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway, http://dx.doi.org/10.1007/978-3-642-58537-1_5
,1998, Positive versus negative signaling by lymphocyte antigen receptors, http://dx.doi.org/10.1146/annurev.immunol.16.1.645
,Book Chapters
2018, 'Sequencing and affinity determination of antigen-specific B lymphocytes from peripheral blood', in Nevoltris D; Chames P (ed.), Antibody Engineering. Methods in Molecular Biology, Humana Press, New York, NY, pp. 287 - 309, http://dx.doi.org/10.1007/978-1-4939-8648-4_15
,2007, 'Closing Remarks', in Decoding the Genomic Control of Immune Reactions, pp. 208 - 209, http://dx.doi.org/10.1002/9780470062128.ch17
,1997, 'Glimpses into the Balance Between Immunity and Self‐Tolerance', in Ciba Foundation Symposium 204 ‐ The Molecular Basis of Cellular Defence Mechanisms, Wiley, pp. 190 - 207, http://dx.doi.org/10.1002/9780470515280.ch13
,1993, 'Tolerant Autoreactive B Lymphocytes in the Follicular Mantle Zone Compartment: Substrates for Receptor Editing and Reform', in Molecular Mechanisms of Immunological Self-Recognition, Elsevier, pp. 25 - 36, http://dx.doi.org/10.1016/b978-0-12-053750-1.50006-4
,1986, 'Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection', in Regulation of Immune Gene Expression, Humana Press, pp. 137 - 142, http://dx.doi.org/10.1007/978-1-4612-5014-2_12
,1985, 'A Monoclonal Antibody with Selectivity for Human Kappa Myeloma and Lymphoma Cells which has Potential as a Therapeutic Agent', in Microenvironments in the Lymphoid System, Springer Nature, pp. 833 - 841, http://dx.doi.org/10.1007/978-1-4613-2463-8_101
,Journal articles
2024, 'The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects', Immunity, 57, pp. 1324 - 1344.e8, http://dx.doi.org/10.1016/j.immuni.2024.04.026
,2024, 'Helper T cell immunity in humans with inherited CD4 deficiency', Journal of Experimental Medicine, 221, http://dx.doi.org/10.1084/jem.20231044
,2024, 'A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome', Journal of Clinical Immunology, 44, http://dx.doi.org/10.1007/s10875-024-01665-1
,2024, 'DOCK2-deficiency causes defects in anti-viral T cell responses and impaired control of herpes simplex virus infection.', J Infect Dis, http://dx.doi.org/10.1093/infdis/jiae077
,2024, 'Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences', Journal of Autoimmunity, 142, http://dx.doi.org/10.1016/j.jaut.2023.103129
,2024, 'Isolation of antigen-specific B cells in ANCA-associated vasculitis; successes and challenges', Pathology, 56, pp. S31 - S31, http://dx.doi.org/10.1016/j.pathol.2023.12.116
,2023, 'Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-36295-5
,2023, 'Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency', Nature, 623, pp. 803 - 813, http://dx.doi.org/10.1038/s41586-023-06717-x
,2023, 'Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy', Molecular Therapy, 31, pp. 1979 - 1993, http://dx.doi.org/10.1016/j.ymthe.2023.03.032
,2023, 'Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL', Leukemia, 37, pp. 1454 - 1463, http://dx.doi.org/10.1038/s41375-023-01918-9
,2023, 'Association of common inherited NOD2 mutations with exceptional response to immune checkpoint inhibitors.', Journal of Clinical Oncology, 41, pp. 2514 - 2514, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2514
,2023, 'CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1095257
,2023, 'Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19', Clinical Immunology, 246, http://dx.doi.org/10.1016/j.clim.2022.109209
,2022, 'STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation', Immunity, 55, pp. 2386 - 2404.e8, http://dx.doi.org/10.1016/j.immuni.2022.11.001
,2022, 'Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases', Breast Cancer Research, 24, http://dx.doi.org/10.1186/s13058-022-01525-z
,2022, 'STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis', Journal of Allergy and Clinical Immunology, 150, pp. 931 - 946, http://dx.doi.org/10.1016/j.jaci.2022.04.011
,2022, 'SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells', Immunology and Cell Biology, 100, pp. 636 - 652, http://dx.doi.org/10.1111/imcb.12566
,2022, 'Genetic and structural basis of the human anti-α-galactosyl antibody response', Proceedings of the National Academy of Sciences of the United States of America, 119, http://dx.doi.org/10.1073/pnas.2123212119
,2022, 'Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells', Science Immunology, 7, http://dx.doi.org/10.1126/sciimmunol.abq3277
,2022, 'Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies', European Journal of Immunology, 52, pp. 970 - 977, http://dx.doi.org/10.1002/eji.202249841
,2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7
,2022, 'Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint', Cell Reports, 38, http://dx.doi.org/10.1016/j.celrep.2021.110259
,2021, 'Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability', Immunity, 54, pp. 2908 - 2921.e6, http://dx.doi.org/10.1016/j.immuni.2021.10.019
,2021, 'Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance', Nature Communications, 12, pp. 2782, http://dx.doi.org/10.1038/s41467-021-23044-9
,2021, 'Calling differentially methylated regions from whole genome bisulphite sequencing with DMRcate', Nucleic Acids Research, 49, http://dx.doi.org/10.1093/nar/gkab637
,2021, 'Human transitional and IgMlow mature naïve B cells preserve permissive B-cell receptors', Immunology and Cell Biology, 99, pp. 865 - 878, http://dx.doi.org/10.1111/imcb.12478
,2021, 'SAMD9L autoinflammatory or ataxia pancytopenia disease mutations activate cell-autonomous translational repression', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2110190118
,2021, 'Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells', Immunology and Cell Biology, 99, pp. 532 - 541, http://dx.doi.org/10.1111/imcb.12433
,2021, 'A point mutation in IKAROS ZF1 causes a B cell deficiency in mice', Journal of Immunology, 206, pp. 1505 - 1514, http://dx.doi.org/10.4049/jimmunol.1901464
,2021, 'Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0237830
,2021, 'NINJ1 mediates plasma membrane rupture during lytic cell death', Nature, 591, pp. 131 - 136, http://dx.doi.org/10.1038/s41586-021-03218-7
,2021, 'COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints', Immunology and Cell Biology, 99, pp. 177 - 191, http://dx.doi.org/10.1111/imcb.12419
,2021, 'DOCK8 deficiency diminishes thymic T-regulatory cell development but not thymic deletion', Clinical and Translational Immunology, 10, http://dx.doi.org/10.1002/cti2.1236
,2021, 'Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility', Journal of Experimental Medicine, 218, http://dx.doi.org/10.1084/JEM.20200476
,2021, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', mAbs, 13, http://dx.doi.org/10.1080/19420862.2021.1922134
,2021, 'Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice', , http://dx.doi.org/10.1101/2021.01.29.428877
,2020, 'Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 22341 - 22350, http://dx.doi.org/10.1073/pnas.2005102117
,2020, 'A divergent transcriptional landscape underpins the development and functional branching of MAIT cells', The Journal of Immunology, 204, pp. 223.8 - 223.8, http://dx.doi.org/10.4049/jimmunol.204.supp.223.8
,2020, 'The effects of germline STAT3-activating mutations from autoimmunity and lymphoid malignancy on mouse and human T cells', The Journal of Immunology, 204, pp. 142.35 - 142.35, http://dx.doi.org/10.4049/jimmunol.204.supp.142.35
,2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029
,