By Professor Christopher Carl Goodnow

Journal articles

Reed JH; Jackson J; Christ D; Goodnow CC, 2016, 'Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization', Journal of Experimental Medicine, 213, pp. 1255 - 1265, http://dx.doi.org/10.1084/jem.20151978

Lam T; Hoffman DM; Cukier K; Darnell D; Greenfield JR; Harrison N; Hng TM; Morrow AF; Cheung NW, 2016, 'Temporal HbA1c patterns amongst patients with type 2 diabetes referred for specialist care: Data from the S4S-DINGO-Diabetes Informatics Group', Diabetes Research and Clinical Practice, 116, pp. 159 - 164, http://dx.doi.org/10.1016/j.diabres.2016.04.006

Dooley J; Tian L; Schonefeldt S; Delghingaro-Augusto V; Garcia-Perez JE; Pasciuto E; Di Marino D; Carr EJ; Oskolkov N; Lyssenko V; Franckaert D; Lagou V; Overbergh L; Vandenbussche J; Allemeersch J; Chabot-Roy G; Dahlstrom JE; Laybutt DR; Petrovsky N; Socha L; Gevaert K; Jetten AM; Lambrechts D; Linterman MA; Goodnow CC; Nolan CJ; Lesage S; Schlenner SM; Liston A, 2016, 'Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes', Nature Genetics, 48, pp. 519 - 527, http://dx.doi.org/10.1038/ng.3531

Wu Z; Liang R; Ohnesorg T; Cho V; Lam W; Abhayaratna WP; Gatenby PA; Perera C; Zhang Y; Whittle B; Sinclair A; Goodnow CC; Field M; Andrews TD; Cook MC, 2016, 'Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion', PLoS Genetics, 12, pp. e1006067, http://dx.doi.org/10.1371/journal.pgen.1006067

Wertz IE; Newton K; Seshasayee D; Kusam S; Lam C; Zhang J; Popovych N; Helgason E; Schoeffler A; Jeet S; Ramamoorthi N; Kategaya L; Newman RJ; Horikawa K; Dugger D; Sandoval W; Mukund S; Zindal A; Martin F; Quan C; Tom J; Fairbrother WJ; Townsend M; Warming S; DeVoss J; Liu J; Dueber E; Caplazi P; Lee WP; Goodnow CC; Balazs M; Yu K; Kolumam G; Dixit VM, 2016, 'Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation (Nature (2015) 528 (370-375) (DOI:10.1038/nature16165))', Nature, 532, pp. 402, http://dx.doi.org/10.1038/nature16541

Lee P; Bova R; Schofield L; Bryant W; Dieckmann W; Slattery A; Govendir MA; Emmett L; Greenfield JR, 2016, 'Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans', Cell Metabolism, 23, pp. 602 - 609, http://dx.doi.org/10.1016/j.cmet.2016.02.007

Hu DY; Yap JY; Wirasinha RC; Howard DR; Goodnow CC; Daley SR, 2016, 'A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development', Immunology and Cell Biology, 94, pp. 357 - 366, http://dx.doi.org/10.1038/icb.2015.95

Tonks KT; Coster AC; Christopher MJ; Chaudhuri R; Xu A; Gagnon-Bartsch J; Chisholm DJ; James DE; Meikle PJ; Greenfield JR; Samocha-Bonet D; Milliken S; Goodnow C, 2016, 'Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans', Obesity, 24, pp. 908 - 916, http://dx.doi.org/10.1002/oby.21448

Andrews TD; Jeelall Y; Talaulikar D; Goodnow CC; Field MA, 2016, 'DeepSNVMiner: A sequence analysis tool to detect emergent, rare mutations in subsets of cell populations', PeerJ, 2016, http://dx.doi.org/10.7717/peerj.2074

Wang JQ; Beutler B; Goodnow CC; Horikawa K, 2016, 'Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88^L265P plasmablasts in vivo', Blood, 128, pp. 1604 - 1608, http://dx.doi.org/10.1182/blood-2016-03-708065

De Sousa SMC; Haghighi KS; Qiu MR; Greenfield JR; Chen DLT, 2016, 'Synchronous Nesidioblastosis, Endocrine Microadenoma, and Intraductal Papillary Mucinous Neoplasia in a Man Presenting with Hyperinsulinemic Hypoglycemia', Pancreas, 45, pp. 154 - 159, http://dx.doi.org/10.1097/MPA.0000000000000430

Ellyard JI; Jerjen R; Martin JL; Lee A; Field MA; Jiang SH; Cappello J; Naumann SK; Andrews TD; Scott HS; Casarotto MG; Goodnow CC; Chaitow J; Pascual V; Hertzog P; Alexander SI; Cook MC; Vinuesa CG, 2016, 'Identification of a pathogenic variant in TREX1 in early-onset cerebral SLE by whole-exome sequencing', Pathology, 48, pp. S47 - S47, http://dx.doi.org/10.1016/j.pathol.2015.12.120

Wertz IE; Newton K; Seshasayee D; Kusam S; Lam C; Zhang J; Popovych N; Helgason E; Schoeffler A; Jeet S; Ramamoorthi N; Kategaya L; Newman RJ; Horikawa K; Dugger D; Sandoval W; Mukund S; Zindal A; Martin F; Quan C; Tom J; Fairbrother WJ; Townsend M; Warming S; Devoss J; Liu J; Dueber E; Caplazi P; Lee WP; Goodnow CC; Balazs M; Yu K; Kolumam G; Dixit VM, 2015, 'Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation', Nature, 528, pp. 370 - 375, http://dx.doi.org/10.1038/nature16165

Lee P; Greenfield JR, 2015, 'Non-pharmacological and pharmacological strategies of brown adipose tissue recruitment in humans', Molecular and Cellular Endocrinology, 418, pp. 184 - 190, http://dx.doi.org/10.1016/j.mce.2015.05.025

Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE; Milliken S; Goodnow C, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, 1, pp. 15010, http://dx.doi.org/10.1038/npjsba.2015.10

Chen DL; Liess C; Poljak A; Xu A; Zhang J; Thoma C; Trenell M; Milner B; Jenkins AB; Chisholm DJ; Samocha-Bonet D; Greenfield JR, 2015, 'Phenotypic characterization of insulin-resistant and insulin-sensitive obesity', Journal of Clinical Endocrinology and Metabolism, 100, pp. 4082 - 4091, http://dx.doi.org/10.1210/jc.2015-2712

Field MA; Cho V; Andrews TD; Goodnow CC, 2015, 'Reliably detecting clinically important variants requires both combined variant calls and optimized filtering strategies', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0143199

Kayagaki N; Stowe IB; Lee BL; O'Rourke K; Anderson K; Warming S; Cuellar T; Haley B; Roose-Girma M; Phung QT; Liu PS; Lill JR; Li H; Wu J; Kummerfeld S; Zhang J; Lee WP; Snipas SJ; Salvesen GS; Morris LX; Fitzgerald L; Zhang Y; Bertram EM; Goodnow CC; Dixit VM, 2015, 'Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling', Nature, 526, pp. 666 - 671, http://dx.doi.org/10.1038/nature15541

Ramiscal RR; Parish IA; Lee-Young RS; Babon JJ; Blagih J; Pratama A; Martin J; Hawley N; Cappello JY; Nieto PF; Ellyard JI; Kershaw NJ; Sweet RA; Goodnow CC; Jones RG; Febbraio MA; Vinuesa CG; Athanasopoulos V, 2015, 'Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation', eLife, 4, pp. 1 - 22, http://dx.doi.org/10.7554/eLife.08698

Greenfield JRF; Kuhn S; Mehler D; Puel F; Rommens PM, 2015, 'Biomechanical evaluation of a new treatment method for distal tibia fractures', COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 18, pp. 1952 - 1953, http://dx.doi.org/10.1080/10255842.2015.1069582

Fuchs S; Rensing-Ehl A; Pannicke U; Lorenz MR; Fisch P; Jeelall Y; Rohr J; Speckmann C; Vraetz T; Farmand S; Schmitt-Graeff A; Krüger M; Strahm B; Henneke P; Enders A; Horikawa K; Goodnow C; Schwarz K; Ehl S, 2015, 'Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency', Blood, 126, pp. 1658 - 1669, http://dx.doi.org/10.1182/blood-2015-03-631374

Miosge LA; Field MA; Sontani Y; Cho V; Johnson S; Palkova A; Balakishnan B; Liang R; Zhang Y; Lyon S; Beutler B; Whittle B; Bertram EM; Enders A; Goodnow CC; Andrewsa TD, 2015, 'Comparison of predicted and actual consequences of missense mutations', Proceedings of the National Academy of Sciences of the United States of America, 112, pp. E5189 - E5198, http://dx.doi.org/10.1073/pnas.1511585112

Tangye SG; Brink R; Goodnow CC; Phan TG, 2015, 'SnapShot: Interactions between B Cells and T Cells', Cell, 162, pp. 926 - 926.e1, http://dx.doi.org/10.1016/j.cell.2015.07.055

Williams RS; Heilbronn LK; Chen DL; Coster A; Greenfield JR; Samocha-Bonet D; Milliken S; Goodnow C; Chen D, 2015, 'Dietary acid load, metabolic acidosis and insulin resistance - Lessons from cross-sectional and overfeeding studies in humans', Clinical Nutrition, 35, pp. 1084 - 1090, http://dx.doi.org/10.1016/j.clnu.2015.08.002

Field MA; Cho V; Cook MC; Enders A; Vinuesa CG; Whittle B; Andrews TD; Goodnow CC, 2015, 'Reducing the search space for causal genetic variants with VASP', Bioinformatics, 31, pp. 2377 - 2379, http://dx.doi.org/10.1093/bioinformatics/btv135

Flesch IEA; Randall KL; Hollett NA; Di Law H; Miosge LA; Sontani Y; Goodnow CC; Tscharke DC, 2015, 'Delayed control of herpes simplex virus infection and impaired CD4⁺ T-cell migration to the skin in mouse models of DOCK8 deficiency', Immunology and Cell Biology, 93, pp. 517 - 521, http://dx.doi.org/10.1038/icb.2015.32

Rahimpour A; Koay HF; Enders A; Clanchy R; Eckle SBG; Meehan B; Chen Z; Whittle B; Liu L; Fairlie DP; Goodnow CC; McCluskey J; Rossjohn J; Uldrich AP; Pellicci DG; Godfrey DI, 2015, 'Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers', Journal of Experimental Medicine, 212, pp. 1095 - 1108, http://dx.doi.org/10.1084/jem.20142110

Sapkota S; Brien JAE; Greenfield JR; Aslani P; Brien J-A; Milliken S; Goodnow C, 2015, 'A systematic review of interventions addressing adherence to anti-diabetic medications in patients with type 2 diabetes - Components of interventions', PLoS ONE, 10, pp. e0128581, http://dx.doi.org/10.1371/journal.pone.0128581

Sapkota S; Brien J-AE; Greenfield JR; Aslani P, 2015, 'A Systematic Review of Interventions Addressing Adherence to Anti-Diabetic Medications in Patients with Type 2 Diabetes—Components of Interventions', PLOS ONE, 10, pp. e0128581 - e0128581, http://dx.doi.org/10.1371/journal.pone.0128581

Johar AS; Mastronardi C; Rojas-Villarraga A; Patel HR; Chuah A; Peng K; Higgins A; Milburn P; Palmer S; Silva-Lara MF; Velez JI; Andrews D; Field M; Huttley G; Goodnow C; Anaya JM; Arcos-Burgos M, 2015, 'Novel and rare functional genomic variants in multiple autoimmune syndrome and Sjögren's syndrome', Journal of Translational Medicine, 13, http://dx.doi.org/10.1186/s12967-015-0525-x

Lee P; Swarbrick MM; Greenfield JR, 2015, 'The sum of all browning in FGF21 therapeutics', Cell Metabolism, 21, pp. 795 - 796, http://dx.doi.org/10.1016/j.cmet.2015.05.018

Samocha-Bonet D; Chisholm DJ; Holst JJ; Greenfield JR; Milliken S; Goodnow C, 2015, 'L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients', Nutrients, 7, pp. 2101 - 2108, http://dx.doi.org/10.3390/nu7042101

Liu Y; DeBoer K; de Kretser DM; O’Donnell L; O’Connor AE; Merriner DJ; Okuda H; Whittle B; Jans DA; Efthymiadis A; McLachlan RI; Ormandy CJ; Goodnow CC; Jamsai D; O’Bryan MK, 2015, 'LRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility', PLoS Genetics, 11, http://dx.doi.org/10.1371/journal.pgen.1005090

Siggs OM; Miosge LA; Daley SR; Asquith K; Foster PS; Liston A; Goodnow CC, 2015, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, 194, pp. 2587 - 2595, http://dx.doi.org/10.4049/jimmunol.1400326

Hillen KM; Gather R; Enders A; Pircher H; Aichele P; Fisch P; Blumenthal B; Schamel WW; Straub T; Goodnow CC; Ehl S, 2015, 'T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: Implications for human immunodeficiency', Journal of Immunology, 194, pp. 2725 - 2734, http://dx.doi.org/10.4049/jimmunol.1400328

Johar AS; Anaya JM; Andrews D; Patel HR; Field M; Goodnow C; Arcos-Burgos M, 2015, 'Candidate gene discovery in autoimmunity by using extreme phenotypes, next generation sequencing and whole exome capture', Autoimmunity Reviews, 14, pp. 204 - 209, http://dx.doi.org/10.1016/j.autrev.2014.10.021

Taupin D; Lam W; Rangiah D; McCallum L; Whittle B; Zhang Y; Andrews D; Field M; Goodnow CC; Cook MC, 2015, 'A deleterious RNF43 germline mutation in a severely affected serrated polyposis kindred', Human Genome Variation, 2, http://dx.doi.org/10.1038/hgv.2015.13

Lim SL; Qu ZP; Kortschak RD; Lawrence DM; Geoghegan J; Hempfling AL; Bergmann M; Goodnow CC; Ormandy CJ; Wong L; Mann J; Scott HS; Jamsai D; Adelson DL; O’Bryan MK, 2015, 'HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse', PLoS Genetics, 11, http://dx.doi.org/10.1371/journal.pgen.1005620

Duong JK; Kumar SS; Furlong TJ; Kirkpatrick CM; Graham GG; Greenfield JR; Williams KM; Day RO, 2015, 'The pharmacokinetics of metformin and concentrations of haemoglobin A1C and lactate in Indigenous and non-Indigenous Australians with type 2 diabetes mellitus', British Journal of Clinical Pharmacology, 79, pp. 617 - 623, http://dx.doi.org/10.1111/bcp.12525

Lim SL; Qu ZP; Kortschak RD; Lawrence DM; Geoghegan J; Hempfling A-L; Bergmann M; Goodnow CC; Ormandy CJ; Wong L; Mann J; Scott HS; Jamsai D; Adelson DL; O'Bryan MK, 2015, 'Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.', PLoS Genet, 11, pp. e1005782, http://dx.doi.org/10.1371/journal.pgen.1005782

Ellyard JI; Jerjen R; Martin JL; Lee AYS; Field MA; Jiang SH; Cappello J; Naumann SK; Andrews TD; Scott HS; Casarotto MG; Goodnow CC; Chaitow J; Pascual V; Hertzog P; Alexander SI; Cook MC; Vinuesa CG, 2014, 'Brief report: Identification of a pathogenic variant in trex1 in early-onset cerebral systemic lupus erythematosus by whole-exome sequencing', Arthritis and Rheumatology, 66, pp. 3382 - 3386, http://dx.doi.org/10.1002/art.38824

Lee CE; Fulcher DA; Whittle B; Chand R; Fewings N; Field M; Andrews D; Goodnow CC; Cook MC, 2014, 'Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100', Blood, 124, pp. 2964 - 2972, http://dx.doi.org/10.1182/blood-2014-06-578542

Han BY; Wu S; Foo CS; Horton RM; Jenne CN; Watson SR; Whittle B; Goodnow CC; Cyster JG, 2014, 'Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment', eLife, 3, pp. 1 - 28, http://dx.doi.org/10.7554/eLife.03549

Zammit NW; Malle EK; Walters SN; Goodnow CC; Grey ST, 2014, 'Functional genomics identifies tnfaip3/A20 as a diabetes protective gene', DIABETOLOGIA, 57, pp. S103 - S103, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344386100229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sabouri Z; Schofield P; Horikawa K; Spierings E; Kipling D; Randall KL; Langley D; Roome B; Vazquez-Lombardi R; Rouet R; Hermes J; Chan TD; Brink R; Dunn-Walters DK; Christ D; Goodnow CC, 2014, 'Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity', Proceedings of the National Academy of Sciences of the United States of America, 111, http://dx.doi.org/10.1073/pnas.1406974111

Enders A; Short A; Miosge LA; Bergmann H; Sontani Y; Bertram EM; Whittle B; Balakishnan B; Yoshida K; Sjollema G; Field MA; Andrews TD; Hagiwara H; Goodnow CC, 2014, 'Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 4513 - 4518, http://dx.doi.org/10.1073/pnas.1402739111

Wang JQ; Jeelall YS; Beutler B; Horikawa K; Goodnow CC, 2014, 'Consequences of the recurrent MYD88^L265P somatic mutation for B cell tolerance', Journal of Experimental Medicine, 211, pp. 413 - 426, http://dx.doi.org/10.1084/jem.20131424

Altin JA; Daley SR; Howitt J; Rickards HJ; Batkin AK; Horikawa K; Prasad SJ; Nelms KA; Kumar S; Wu LC; Tan SS; Cook MC; Goodnow CC, 2014, 'Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4⁺ T cells', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 2067 - 2074, http://dx.doi.org/10.1073/pnas.1322739111

Siggs OM; Yates AL; Schlenner S; Liston A; Lesage S; Goodnow CC, 2014, 'A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction', Immunology, 141, pp. 587 - 595, http://dx.doi.org/10.1111/imm.12220

Bull KR; Mason T; Rimmer AJ; Crockford TL; Silver KL; Bouriez-Jones T; Hough TA; Chaudhry S; Roberts ISD; Goodnow CC; Cornall RJ, 2014, 'Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome', Journal of Pathology, 233, pp. 18 - 26, http://dx.doi.org/10.1002/path.4308

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