By Professor Christopher Carl Goodnow

Journal articles

Li G; Vega R; Nelms K; Gekakis N; Goodnow C; McNamara P; Wu H; Hong N; Glynne R, 2005, 'A role for the Alström syndrome protein, Alms1, in ciliogenesis and regulation of cellular quiescence in kidney proximal tubules', PLoS Genetics, preprint, pp. e8 - e8, http://dx.doi.org/10.1371/journal.pgen.0030008.eor

Liston A; Gray DHD; Lesage S; Fletcher AL; Wilson J; Webster KE; Scott HS; Boyd RL; Peltonen L; Goodnow CC, 2004, 'Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity', Journal of Experimental Medicine, 200, pp. 1015 - 1026, http://dx.doi.org/10.1084/jem.20040581

Kennedy CL; O’Connor AE; Sanchez-Partida LG; Goodnow CC; De Kretser DM; O'Bryan MK, 2004, '126. A repository of ENU mutant mouse lines and their potential for male fertility research', Reproduction, Fertility and Development, 16, pp. 126 - 126, http://dx.doi.org/10.1071/srb04abs126

Vinuesa CG; Goodnow CC, 2004, 'Illuminating autoimmune regulators through controlled variation of the mouse genome sequence', Immunity, 20, pp. 669 - 679, http://dx.doi.org/10.1016/j.immuni.2004.05.012

Liston A; Lesage S; Gray DHD; O reilly LA; Strasser A; Fahrer AM; Boyd RL; Wilson J; Baxter AG; Gallo E; Crabtree GR; Peng K; Wilson SR; Goodnow CC, 2004, 'Generalised resistance to thymic deletion in the NODmouse: a polygenic trait characterized by defective induction of Bim', Immunity, 21, pp. 817 - 830

Jun JE; Goodnow CC, 2003, 'Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling', Nature Immunology, 4, pp. 1057 - 1064, http://dx.doi.org/10.1038/ni1001

Kennedy C; Swain L; Eddy A; Reilly A; Cram D; Goodnow C; Kretser DD; O'Bryan M, 2003, '8. The identification of mutations affecting male fertility using denaturing high performance liquid chromatography', Reproduction, Fertility and Development, 15, pp. 8 - 8, http://dx.doi.org/10.1071/srb03ab8

Papathanasiou P; Perkins AC; Cobb BS; Ferrini R; Sridharan R; Hoyne GF; Nelms KA; Smale ST; Goodnow CC, 2003, 'Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the ikaros transcription factor', Immunity, 19, pp. 131 - 144, http://dx.doi.org/10.1016/S1074-7613(03)00168-7

Jun JE; Wilson LE; Vinuesa CG; Lesage S; Blery M; Miosge LA; Cook MC; Kucharska EM; Hara H; Penninger JM; Domashenz H; Hong NA; Glynne RJ; Nelms KA; Goodnow CC, 2003, 'Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis', Immunity, 18, pp. 751 - 762, http://dx.doi.org/10.1016/S1074-7613(03)00141-9

Rui L; Vinuesa CG; Blasioli J; Goodnow CC, 2003, 'Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling', Nature Immunology, 4, pp. 594 - 600, http://dx.doi.org/10.1038/ni924

Liston A; Lesage S; Wilson J; Peltonen L; Goodnow CC, 2003, 'Aire regulates negative selection of organ-specific T cells', Nature Immunology, 4, pp. 350 - 354, http://dx.doi.org/10.1038/ni906

Lesage S; Hartley SB; Akkaraju S; Wilson J; Townsend M; Goodnow CC, 2002, 'Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes', Journal of Experimental Medicine, 196, pp. 1175 - 1188, http://dx.doi.org/10.1084/jem.20020735

Miosge LA; Blasioli J; Blery M; Goodnow CC, 2002, 'Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor κB2 in regulating circulating B cell numbers', Journal of Experimental Medicine, 196, pp. 1113 - 1119, http://dx.doi.org/10.1084/jem.20020959

Prasad SJ; Goodnow CC, 2002, 'Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes', Immunology and Cell Biology, 80, pp. 198 - 206, http://dx.doi.org/10.1046/j.1440-1711.2002.01074.x

Vinuesa CG; Goodnow CC, 2002, 'DNA drives autoimmunity', Nature, 416, pp. 595 - 598, http://dx.doi.org/10.1038/416595a

Loy AL; Goodnow CC, 2002, 'Novel approaches for identifying genes regulating lymphocyte development and function', Current Opinion in Immunology, 14, pp. 260 - 265, http://dx.doi.org/10.1016/S0952-7915(02)00331-X

Martin SW; Goodnow CC, 2002, 'Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory', Nature Immunology, 3, pp. 182 - 188, http://dx.doi.org/10.1038/ni752

Prasad SJ; Goodnow CC, 2002, 'Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo', International Immunology, 14, pp. 677 - 684, http://dx.doi.org/10.1093/intimm/dxf034

Blasioli J; Goodnow CC, 2002, 'Lyn/CD22/SHP-1 and their importance in autoimmunity.', Current Directions in Autoimmunity, 5, pp. 151 - 160

Lesage S; Goodnow CC, 2001, 'Organ-specific autoimmune disease: A deficiency of tolerogenic stimulation', Journal of Experimental Medicine, 194, pp. F31 - F36, http://dx.doi.org/10.1084/jem.194.5.F31

Goodnow CC, 2001, 'Pathways for self-tolerance and the treatment of autoimmune diseases', Lancet, 357, pp. 2115 - 2121, http://dx.doi.org/10.1016/S0140-6736(00)05185-0

Townsend SE; Goodnow CC; Cornall RJ, 2001, 'Single epitope multiple staining to detect ultralow frequency B cells', Journal of Immunological Methods, 249, pp. 137 - 146, http://dx.doi.org/10.1016/S0022-1759(00)00352-5

Nadeau JH; Balling R; Barsh G; Beier D; Brown SDM; Bucan M; Camper S; Carlson G; Copeland N; Eppig J; Fletcher C; Frankel WN; Ganten D; Goldowitz D; Goodnow C; Guenet JL; Hicks G; De Angelis MH; Jackson I; Jacob HJ; Jenkins N; Johnson D; Justice M; Kay S; Kingsley D; Lehrach H; Magnuson T; Meisler M; Poustka A; Rinchik EM; Rossant J; Russell LB; Schimenti J; Shiroishi T; Skarnes WC; Soriano P; Stanford W; Takahashi JS; Wurst W; Zimmer A, 2001, 'Sequence interpretation: Functional annotation of mouse genome sequences', Science, 291, pp. 1251 - 1255, http://dx.doi.org/10.1126/science.1058244

Fahrer AM; Bazan FJ; Papathanasiou P; Nelms KA; Goodnow CC, 2001, 'A genomic view of immunology', Nature, 409, pp. 836 - 838, http://dx.doi.org/10.1038/35057020

Goodnow CC; Glynne R; Akkaraju S; Rayner J; Mack D; Healy JI; Chaudhry S; Miosge L; Wilson L; Papathanasiou P; Loy A, 2001, 'Autoimmunity, self-tolerance and immune homeostasis: From whole animal phenotypes to molecular pathways', Advances in Experimental Medicine and Biology, 490, pp. 33 - 40, http://dx.doi.org/10.1007/978-1-4615-1243-1_4

Nelms KA; Goodnow CC, 2001, 'Genome-wide ENU mutagenesis to reveal immune regulators', Immunity, 15, pp. 409 - 418, http://dx.doi.org/10.1016/S1074-7613(01)00199-6

Martin S; Goodnow C, 2000, 'Memory needs no reminders', Nature, 407, pp. 576 - 577, http://dx.doi.org/10.1038/35036673

Glynne R; Akkaraju S; Healy JI; Rayner J; Goodnow CC; Mack DH, 2000, 'Erratum: How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis (Nature (2000) 403: (672-676))', Nature, 407, pp. 413, http://dx.doi.org/10.1038/35030187

Glynne R; Akkaraju S; Healy JI; Rayner J; Goodnow CC; Mack DH, 2000, 'How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis (vol 403, pg 672, 2000)', NATURE, 407, pp. 413 - +, http://dx.doi.org/10.1038/35030187

Weintraub BC; Jun JE; Bishop AC; Shokat KM; Thomas ML; Goodnow CC, 2000, 'Entry of B cell receptor into signaling domains is inhibited in tolerant B cells', Journal of Experimental Medicine, 191, pp. 1443 - 1448, http://dx.doi.org/10.1084/jem.191.8.1443

Glynne RJ; Ghandour G; Goodnow CC, 2000, 'Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy', Current Opinion in Immunology, 12, pp. 210 - 214, http://dx.doi.org/10.1016/S0952-7915(99)00076-X

Pogue SL; Goodnow CC, 2000, 'Gene dose-dependent maturation and receptor editing of B cells expressing immunoglobulin (Ig)G1 or IgM/IgG1 tail antigen receptors', Journal of Experimental Medicine, 191, pp. 1031 - 1043, http://dx.doi.org/10.1084/jem.191.6.1031

Cornall RJ; Cheng AM; Pawson T; Goodnow CC, 2000, 'Role of Syk in B-cell development and antigen-receptor signaling', Proceedings of the National Academy of Sciences of the United States of America, 97, pp. 1713 - 1718, http://dx.doi.org/10.1073/pnas.97.4.1713

Glynne R; Akkaraju S; Healy JI; Rayner J; Goodnow CC; Mack DH, 2000, 'How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis', Nature, 403, pp. 672 - 676, http://dx.doi.org/10.1038/35001102

Glynne R; Ghandour G; Rayner J; Mack DH; Goodnow CC, 2000, 'B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays', Immunological Reviews, 176, pp. 216 - 246, http://dx.doi.org/10.1034/j.1600-065X.2000.00614.x

Townsend SE; Weintraub BC; Goodnow CC, 1999, 'Growing up on the streets: Why B-cell development differs from T-cell development', Immunology Today, 20, pp. 217 - 220, http://dx.doi.org/10.1016/S0167-5699(98)01440-6

Goodnow CC, 1998, 'Cancer immunotherapy: New leads on an elusive goal', Medical Journal of Australia, 169, pp. 570 - 571, http://dx.doi.org/10.5694/j.1326-5377.1998.tb123418.x

Rathmell JC; Goodnow CC, 1998, 'The in vivo balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment', Immunology and Cell Biology, 76, pp. 387 - 394, http://dx.doi.org/10.1046/j.1440-1711.1998.00774.x

Ying H; Healy JI; Goodnow CC; Parnes JR, 1998, 'Regulation of mouse CD72 gene expression during B lymphocyte development', Journal of Immunology, 161, pp. 4760 - 4767, http://dx.doi.org/10.4049/jimmunol.161.9.4760

Rathmell JC; Fournier S; Weintraub BC; Allison JP; Goodnow CC, 1998, 'Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4+ T cells', Journal of Experimental Medicine, 188, pp. 651 - 659, http://dx.doi.org/10.1084/jem.188.4.651

Weintraub BC; Goodnow CC, 1998, 'Immune responses: Costimulatory receptors have their say', Current Biology, 8, pp. R575 - R577, http://dx.doi.org/10.1016/s0960-9822(07)00365-x

Townsend SE; Goodnow CC, 1998, 'Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo', Journal of Experimental Medicine, 187, pp. 1611 - 1621, http://dx.doi.org/10.1084/jem.187.10.1611

Fischer MB; Goerg S; Shen LM; Prodeus AP; Goodnow CC; Kelsoe G; Carroll MC, 1998, 'Dependence of germinal center B cells on expression of CD21/CD35 for survival', Science, 280, pp. 582 - 585, http://dx.doi.org/10.1126/science.280.5363.582

Schmidt KN; Hsu CW; Griffin CT; Goodnow CC; Cyster JG, 1998, 'Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells', Journal of Experimental Medicine, 187, pp. 929 - 937, http://dx.doi.org/10.1084/jem.187.6.929

Prodeus AP; Goerg S; Shen LM; Pozdnyakova OO; Chu L; Alicot EM; Goodnow CC; Carroll MC, 1998, 'A critical role for complement in maintenance of self-tolerance', Immunity, 9, pp. 721 - 731, http://dx.doi.org/10.1016/S1074-7613(00)80669-X

Cornall RJ; Goodnow CC, 1998, 'B cell antigen receptor signalling in the balance of tolerance and immunity.', Novartis Foundation Symposium, 215, pp. 21 - 3040

Cornall RJ; Cyster JG; Hibbs ML; Dunn AR; Otipoby KL; Clark EA; Goodnow CC, 1998, 'Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection', Immunity, 8, pp. 497 - 508, http://dx.doi.org/10.1016/S1074-7613(00)80554-3

Healy JI; Dolmetsch RE; Lewis RS; Goodnow CC, 1998, 'Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes.', Novartis Foundation Symposium, 215, pp. 137 - 190

Fang W; Weintraub BC; Dunlap B; Garside P; Pape KA; Jenkins MK; Goodnow CC; Mueller DL; Behrens TW, 1998, 'Self-reactive B lymphocytes overexpressing Bcl-x(L) escape negative selection and are tolerized by clonal anergy and receptor editing', Immunity, 9, pp. 35 - 45, http://dx.doi.org/10.1016/S1074-7613(00)80586-5

Akkaraju S; Canaan K; Goodnow CC, 1997, 'Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells', Journal of Experimental Medicine, 186, pp. 2005 - 2012, http://dx.doi.org/10.1084/jem.186.12.2005

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