By Professor Christopher Carl Goodnow

Journal articles

Shiow LR; Roadcap DW; Paris K; Watson SR; Grigorova IL; Lebet T; An J; Xu Y; Jenne CN; Föger N; Sorensen RU; Goodnow CC; Bear JE; Puck JM; Cyster JG, 2008, 'The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency', Nature Immunology, 9, pp. 1307 - 1315, http://dx.doi.org/10.1038/ni.1662

Gosling KM; Goodnow CC; Verma NK; Fahrer AM, 2008, 'Defective T-cell function leading to reduced antibody production in a kleisin-β mutant mouse', Immunology, 125, pp. 208 - 217, http://dx.doi.org/10.1111/j.1365-2567.2008.02831.x

Heazlewood CK; Cook MC; Eri R; Price GR; Tauro SB; Taupin D; Thornton DJ; Chin WP; Crockford TL; Cornall RJ; Adams R; Kato M; Nelms KA; Hong NA; Florin THJ; Goodnow CC; McGuckin MA, 2008, 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', PLoS Medicine, 5, pp. 0440 - 0460, http://dx.doi.org/10.1371/journal.pmed.0050054

Yu D; Tan AHM; Hu X; Athanasopoulos V; Simpson N; Silva DG; Hutloff A; Giles KM; Leedman PJ; Lam KP; Goodnow CC; Vinuesa CG, 2008, 'Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA (Nature (2007) 450, (299-303))', Nature, 451, pp. 1022, http://dx.doi.org/10.1038/nature06729

Liu M; Duke JL; Richter DJ; Vinuesa CG; Goodnow CC; Kleinstein SH; Schatz DG, 2008, 'Two levels of protection for the B cell genome during somatic hypermutation', Nature, 451, pp. 841 - 845, http://dx.doi.org/10.1038/nature06547

Yu D; Cook MC; Shin DM; Silva DG; Marshall J; Toellner KM; Havran WL; Caroni P; Cooke MP; Morse HC; MacLennan ICM; Goodnow CC; Vinuesa CG, 2008, 'Axon growth and guidance genes identify T-dependent germinal centre B cells', Immunology and Cell Biology, 86, pp. 3 - 14, http://dx.doi.org/10.1038/sj.icb.7100123

Keyes J; Tallack M; Zhan Y; Papathanasiou P; Goodnow CC; Gaensler K; Crossley M; Dekker JP; Perkins A, 2008, 'A mechanism for Ikaros regulation of human globin gene switching', British Journal of Haematology, 141, pp. 398 - 406

Siggs OM; Miosge LA; Yates AL; Kucharska EM; Sheahan D; Brdicka T; Weiss A; Liston A; Goodnow CC, 2007, 'Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions', Immunity, 27, pp. 912 - 926, http://dx.doi.org/10.1016/j.immuni.2007.11.013

Di Yu ; Tan AHM; Hu X; Athanasopoulos V; Simpson N; Silva DG; Hutloff A; Giles KM; Leedman PJ; Lam KP; Goodnow CC; Vinuesa CG, 2007, 'Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA', Nature, 450, pp. 299 - 303, http://dx.doi.org/10.1038/nature06253

Goodnow CC, 2007, 'Nossal and Pike 1975: A turning point in the effort to define self-tolerance mechanisms', Journal of Immunology, 179, pp. 5617 - 5618, http://dx.doi.org/10.4049/jimmunol.179.9.5617

Gosling KM; Makaroff LE; Theodoratos A; Kim YH; Whittle B; Rui L; Wu H; Hong NA; Kennedy GC; Fritz JA; Yates AL; Goodnow CC; Fahrer AM, 2007, 'A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 12445 - 12450, http://dx.doi.org/10.1073/pnas.0704870104

Goodnow CC, 2007, 'Multistep Pathogenesis of Autoimmune Disease', Cell, 130, pp. 25 - 35, http://dx.doi.org/10.1016/j.cell.2007.06.033

Nijnik A; Woodbine L; Marchetti C; Dawson S; Lambe T; Liu C; Rodrigues NP; Crockford TL; Cabuy E; Vindigni A; Enver T; Bell JI; Slijepcevic P; Goodnow CC; Jeggo PA; Cornall RJ, 2007, 'DNA repair is limiting for haematopoietic stem cells during ageing', Nature, 447, pp. 686 - 690, http://dx.doi.org/10.1038/nature05875

Liston A; Siggs OM; Goodnow CC, 2007, 'Tracing the action of IL-2 in tolerance to islet-specific antigen', Immunology and Cell Biology, 85, pp. 338 - 342, http://dx.doi.org/10.1038/sj.icb.7100049

Goodnow CC; Campbell JA; Rui L; Vinuesa CG, 2007, 'Tolerance mechanisms in the late phase of the antibody response.', Advances in experimental medicine and biology, 596, pp. 163 - 168

Horikawa K; Martin SW; Pogue SL; Silver K; Peng K; Takatsu K; Goodnow CC, 2007, 'Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors', Journal of Experimental Medicine, 204, pp. 759 - 769, http://dx.doi.org/10.1084/jem.20061923

Li G; Vega R; Nelms K; Gekakis N; Goodnow C; McNamara P; Wu H; Hong NA; Glynne R, 2007, 'A role for Alström syndrome protein, Alms1, in kidney ciliogenesis and cellular quiescence', PLoS Genetics, 3, pp. 0009 - 0020, http://dx.doi.org/10.1371/journal.pgen.0030008

Liston A; Hardy K; Pittelkow YE; Wilson SR; Makarof LE; Fahrer AM; Goodnow CC, 2007, 'Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling', Genome Biology, 8, pp. R12 - R12

Kennedy CL; O'Connor AE; Sanchez-Partida LG; Holland MK; Goodnow CC; de Kretser DM; O'Bryan MK, 2006, 'A repository of ENU mutant mouse lines and their potential for male fertility research', Molecular Human Reproduction, 11, pp. 871 - 880, http://dx.doi.org/10.1093/molehr/gah251

Gray DHD; Seach N; Ueno T; Milton MK; Liston A; Lew AM; Goodnow CC; Boyd RL, 2006, 'Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells', Blood, 108, pp. 3777 - 3785, http://dx.doi.org/10.1182/blood-2006-02-004531

Alexander WS; Viney EM; Zhang JG; Metcalf D; Kauppi M; Hyland CD; Carpinelli MR; Stevenson W; Croker BA; Hilton AA; Ellis S; Selan C; Nandurkar HH; Goodnow CC; Kile BT; Nicola NA; Roberts AW; Hilton DJ, 2006, 'Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 16442 - 16447, http://dx.doi.org/10.1073/pnas.0607872103

Manderson AP; Quah B; Botto M; Goodnow CC; Walport MJ; Parish CR, 2006, 'A novel mechanism for complement activation at the surface of B cells following antigen binding', Journal of Immunology, 177, pp. 5155 - 5162, http://dx.doi.org/10.4049/jimmunol.177.8.5155

Rui L; Healy JI; Blasioli J; Goodnow CC, 2006, 'ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation', Journal of Immunology, 177, pp. 5337 - 5346, http://dx.doi.org/10.4049/jimmunol.177.8.5337

Cook MC; Vinuesa CG; Goodnow CC, 2006, 'ENU-mutagenesis: insight into immune function and pathology', Current Opinion in Immunology, 18, pp. 627 - 633, http://dx.doi.org/10.1016/j.coi.2006.07.011

Bléry M; Tze L; Miosge LA; Jun JE; Goodnow CC, 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy', The Journal of Cell Biology, 174, pp. i5 - i5, http://dx.doi.org/10.1083/jcb1742oia5

Bléry M; Tze L; Miosge LA; Jun JE; Goodnow CC, 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy', Journal of Experimental Medicine, 203, pp. 1773 - 1783, http://dx.doi.org/10.1084/jem.20060552

Nijnik A; Ferry H; Lewis G; Rapsomaniki E; Leung JCH; Daser A; Lambe T; Goodnow CC; Cornall RJ, 2006, 'Spontaneous B cell hyperactivity in autoimmune-prone MRL mice', International Immunology, 18, pp. 1127 - 1137, http://dx.doi.org/10.1093/intimm/dxl047

Goodnow CC, 2006, 'Discriminating microbe from self suffers a double toll', Science, 312, pp. 1606 - 1608, http://dx.doi.org/10.1126/science.1129797

Rui L; Goodnow CC, 2006, 'Lymphoma and the control of B cell growth and differentiation', Current Molecular Medicine, 6, pp. 291 - 308, http://dx.doi.org/10.2174/156652406776894563

Arsov T; Larter CZ; Nolan CJ; Petrovsky N; Goodnow CC; Teoh NC; Yeh MM; Farrell GC, 2006, 'Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice', Biochemical and Biophysical Research Communications, 342, pp. 1152 - 1159, http://dx.doi.org/10.1016/j.bbrc.2006.02.032

Hoyne GF; Goodnow CC, 2006, 'The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: Identifying genes that regulate organ-specific and systemic autoimmunity', Immunological Reviews, 210, pp. 27 - 39, http://dx.doi.org/10.1111/j.0105-2896.2006.00363.x

Arsov T; Silva D; O Bryan M; Sainsbury A; Lee NJ; Kennedy C; Manji S; Nelms K; Liu C; Vinuesa C; de Kretser D, 2006, 'Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis', Molecular Endocrinology, 20, pp. 1610 - 1622

Ferry H; Crockford TL; Silver K; Rust N; Goodnow CC; Cornall RJ, 2005, 'Erratum: Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22- independent pathways affecting BCR regulation and B cell survival (European Journal of Immunology (2005) vol. 35 (12) (3714) 10.1002/eji.200535247)', European Journal of Immunology, 35, pp. 3714, http://dx.doi.org/10.1002/eji.255590598

Miosge LA; Goodnow CC, 2005, 'Genes, pathways and checkpoints in lymphocyte development and homeostasis', Immunology and Cell Biology, 83, pp. 318 - 335, http://dx.doi.org/10.1111/j.1440-1711.2005.01353.x

Goodnow CC; Sprent J; Barbara BF; Vinuesa CG, 2005, 'Cellular and genetic mechanisms of self tolerance and autoimmunity', Nature, 435, pp. 590 - 597, http://dx.doi.org/10.1038/nature03724

Vinuesa CG; Cook MC; Angelucci C; Athanasopoulos V; Rui L; Hill KM; Yu D; Domaschenz H; Whittle B; Lambe T; Roberts IS; Copley RR; Bell JI; Cornall RJ; Goodnow CC, 2005, 'A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity', Nature, 435, pp. 452 - 458, http://dx.doi.org/10.1038/nature03555

Liston A; Lesage S; Gray DHD; Boyd RL; Goodnow CC, 2005, 'Genetic lesions in T-cell tolerance and thresholds for autoimmunity', Immunological Reviews, 204, pp. 87 - 101, http://dx.doi.org/10.1111/j.0105-2896.2005.00253.x

Ferry H; Cockford TL; Silver K; Rust N; Goodnow CC; Cornall R, 2005, 'Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival', European Journal of Immunology, 35, pp. 3655 - 3663, http://dx.doi.org/10.1002/eji.200535247

Li G; Vega R; Nelms K; Gekakis N; Goodnow C; McNamara P; Wu H; Hong N; Glynne R, 2005, 'A role for the Alström syndrome protein, Alms1, in ciliogenesis and regulation of cellular quiescence in kidney proximal tubules', PLoS Genetics, preprint, pp. e8 - e8, http://dx.doi.org/10.1371/journal.pgen.0030008.eor

Liston A; Gray DHD; Lesage S; Fletcher AL; Wilson J; Webster KE; Scott HS; Boyd RL; Peltonen L; Goodnow CC, 2004, 'Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity', Journal of Experimental Medicine, 200, pp. 1015 - 1026, http://dx.doi.org/10.1084/jem.20040581

Vinuesa CG; Goodnow CC, 2004, 'Illuminating autoimmune regulators through controlled variation of the mouse genome sequence', Immunity, 20, pp. 669 - 679, http://dx.doi.org/10.1016/j.immuni.2004.05.012

Kennedy CL; O’Connor AE; Sanchez-Partida LG; Goodnow CC; De Kretser DM; O'Bryan MK, 2004, '126.A repository of ENU mutant mouse lines and their potential for male fertility research', Reproduction, Fertility and Development, 16, pp. 126 - 126, http://dx.doi.org/10.1071/srb04abs126

Liston A; Lesage S; Gray DHD; O reilly LA; Strasser A; Fahrer AM; Boyd RL; Wilson J; Baxter AG; Gallo E; Crabtree GR; Peng K; Wilson SR; Goodnow CC, 2004, 'Generalised resistance to thymic deletion in the NODmouse: a polygenic trait characterized by defective induction of Bim', Immunity, 21, pp. 817 - 830

Jun JE; Goodnow CC, 2003, 'Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling', Nature Immunology, 4, pp. 1057 - 1064, http://dx.doi.org/10.1038/ni1001

Papathanasiou P; Perkins AC; Cobb BS; Ferrini R; Sridharan R; Hoyne GF; Nelms KA; Smale ST; Goodnow CC, 2003, 'Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the ikaros transcription factor', Immunity, 19, pp. 131 - 144, http://dx.doi.org/10.1016/S1074-7613(03)00168-7

Jun JE; Wilson LE; Vinuesa CG; Lesage S; Blery M; Miosge LA; Cook MC; Kucharska EM; Hara H; Penninger JM; Domashenz H; Hong NA; Glynne RJ; Nelms KA; Goodnow CC, 2003, 'Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis', Immunity, 18, pp. 751 - 762, http://dx.doi.org/10.1016/S1074-7613(03)00141-9

Rui L; Vinuesa CG; Blasioli J; Goodnow CC, 2003, 'Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling', Nature Immunology, 4, pp. 594 - 600, http://dx.doi.org/10.1038/ni924

Liston A; Lesage S; Wilson J; Peltonen L; Goodnow CC, 2003, 'Aire regulates negative selection of organ-specific T cells', Nature Immunology, 4, pp. 350 - 354, http://dx.doi.org/10.1038/ni906

Lesage S; Hartley SB; Akkaraju S; Wilson J; Townsend M; Goodnow CC, 2002, 'Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes', Journal of Experimental Medicine, 196, pp. 1175 - 1188, http://dx.doi.org/10.1084/jem.20020735

Miosge LA; Blasioli J; Blery M; Goodnow CC, 2002, 'Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor κB2 in regulating circulating B cell numbers', Journal of Experimental Medicine, 196, pp. 1113 - 1119, http://dx.doi.org/10.1084/jem.20020959

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