By Professor Christopher Carl Goodnow

Journal articles

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.', Journal of Immunology Baltimore Md 1950, 183, pp. 5442 - 5448

Jenne CN; Enders A; Rivera R; Watson SR; Bankovich AJ; Pereira JP; Xu Y; Roots CM; Beilke JN; Banerjee A; Reiner SL; Miller SA; Weinmann AS; Goodnow CC; Lanier LL; Cyster JG; Chun J, 2009, 'T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow', Journal of Experimental Medicine, 206, pp. 2469 - 2481, http://dx.doi.org/10.1084/jem.20090525

Johnson AL; Aravind L; Shulzhenko N; Morgun A; Choi SY; Crockford TL; Lambe T; Domaschenz H; Kucharska EM; Zheng L; Vinuesa CG; Lenardo MJ; Goodnow CC; Cornall RJ; Schwartz RH, 2009, 'Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection', Nature Immunology, 10, pp. 831 - 839, http://dx.doi.org/10.1038/ni.1769

Nijnik A; Dawson S; Crockford TL; Woodbine L; Visetnoi S; Bennett S; Jones M; Turner GD; Jeggo PA; Goodnow CC; Cornall RJ, 2009, 'Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome', Journal of Clinical Investigation, 119, pp. 1696 - 1705, http://dx.doi.org/10.1172/JCI32743

Lambe T; Simpson RJ; Dawson S; Bouriez-Jones T; Crockford TL; Lepherd M; Latunde-Dada GO; Robinson H; Raja KB; Campagna DR; Villarreal G; Ellory JC; Goodnow CC; Fleming MD; McKie AT; Cornall RJ, 2009, 'Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism', Blood, 113, pp. 1805 - 1808, http://dx.doi.org/10.1182/blood-2007-11-120402

Chu J; Hong NA; Masuda CA; Jenkins BV; Nelms KA; Goodnow CC; Glynne RJ; Wu H; Masliah E; Joazeiro CAP; Kay SA, 2009, 'A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 2097 - 2103, http://dx.doi.org/10.1073/pnas.0812819106

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; Mackay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa C; Batista FD; Cornall RJ; Goodnow CC, 2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19898472

Linterman MA; Rigby RJ; Wong R; Silva D; Withers D; Anderson G; Verma NK; Brink R; Hutloff A; Goodnow CC; Vinuesa C, 2009, 'Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS', Immunity, 30, pp. 228 - 241, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19217324

Wu Z; Jia X; de la Cruz L; Su XC; Marzolf B; Troisch P; Zak D; Hamilton A; Whittle B; Yu D; Sheahan D; Bertram E; Aderem A; Otting G; Goodnow CC; Hoyne GF, 2008, 'Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL', Immunity, 29, pp. 863 - 875, http://dx.doi.org/10.1016/j.immuni.2008.11.004

Shiow LR; Roadcap DW; Paris K; Watson SR; Grigorova IL; Lebet T; An J; Xu Y; Jenne CN; Föger N; Sorensen RU; Goodnow CC; Bear JE; Puck JM; Cyster JG, 2008, 'The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency', Nature Immunology, 9, pp. 1307 - 1315, http://dx.doi.org/10.1038/ni.1662

Gosling KM; Goodnow CC; Verma NK; Fahrer AM, 2008, 'Defective T-cell function leading to reduced antibody production in a kleisin-β mutant mouse', Immunology, 125, pp. 208 - 217, http://dx.doi.org/10.1111/j.1365-2567.2008.02831.x

Heazlewood CK; Cook MC; Eri R; Price GR; Tauro SB; Taupin D; Thornton DJ; Chin WP; Crockford TL; Cornall RJ; Adams R; Kato M; Nelms KA; Hong NA; Florin THJ; Goodnow CC; McGuckin MA, 2008, 'Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis', Plos Medicine, 5, pp. 0440 - 0460, http://dx.doi.org/10.1371/journal.pmed.0050054

Yu D; Tan AHM; Hu X; Athanasopoulos V; Simpson N; Silva DG; Hutloff A; Giles KM; Leedman PJ; Lam KP; Goodnow CC; Vinuesa CG, 2008, 'Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA (Nature (2007) 450, (299-303))', Nature, 451, pp. 1022, http://dx.doi.org/10.1038/nature06729

Liu M; Duke JL; Richter DJ; Vinuesa CG; Goodnow CC; Kleinstein SH; Schatz DG, 2008, 'Two levels of protection for the B cell genome during somatic hypermutation', Nature, 451, pp. 841 - 845, http://dx.doi.org/10.1038/nature06547

Yu D; Cook MC; Shin DM; Silva DG; Marshall J; Toellner KM; Havran WL; Caroni P; Cooke MP; Morse HC; MacLennan ICM; Goodnow CC; Vinuesa CG, 2008, 'Axon growth and guidance genes identify T-dependent germinal centre B cells', Immunology and Cell Biology, 86, pp. 3 - 14, http://dx.doi.org/10.1038/sj.icb.7100123

Keyes J; Tallack M; Zhan Y; Papathanasiou P; Goodnow CC; Gaensler K; Crossley M; Dekker JP; Perkins A, 2008, 'A mechanism for Ikaros regulation of human globin gene switching', British Journal of Haematology, 141, pp. 398 - 406

Siggs OM; Miosge LA; Yates AL; Kucharska EM; Sheahan D; Brdicka T; Weiss A; Liston A; Goodnow CC, 2007, 'Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions', Immunity, 27, pp. 912 - 926, http://dx.doi.org/10.1016/j.immuni.2007.11.013

Perkins AC; Tallack M; Zhan Y; Papathanasiou P; Goodnow C; Gaensler K; Crossley PM; Dekker J; Keys JR, 2007, 'Ikaros Drives Human Haemoglobin Switching by Facilitating Active Chromatin Hub Formation.', Blood, 110, pp. 1772 - 1772, http://dx.doi.org/10.1182/blood.v110.11.1772.1772

Di Yu ; Tan AHM; Hu X; Athanasopoulos V; Simpson N; Silva DG; Hutloff A; Giles KM; Leedman PJ; Lam KP; Goodnow CC; Vinuesa CG, 2007, 'Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA', Nature, 450, pp. 299 - 303, http://dx.doi.org/10.1038/nature06253

Goodnow CC, 2007, 'Nossal and Pike 1975: A turning point in the effort to define self-tolerance mechanisms', Journal of Immunology, 179, pp. 5617 - 5618, http://dx.doi.org/10.4049/jimmunol.179.9.5617

Gosling KM; Makaroff LE; Theodoratos A; Kim YH; Whittle B; Rui L; Wu H; Hong NA; Kennedy GC; Fritz JA; Yates AL; Goodnow CC; Fahrer AM, 2007, 'A mutation in a chromosome condensin II subunit, kleisin β, specifically disrupts T cell development', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 12445 - 12450, http://dx.doi.org/10.1073/pnas.0704870104

Goodnow CC, 2007, 'Multistep Pathogenesis of Autoimmune Disease', Cell, 130, pp. 25 - 35, http://dx.doi.org/10.1016/j.cell.2007.06.033

Nijnik A; Woodbine L; Marchetti C; Dawson S; Lambe T; Liu C; Rodrigues NP; Crockford TL; Cabuy E; Vindigni A; Enver T; Bell JI; Slijepcevic P; Goodnow CC; Jeggo PA; Cornall RJ, 2007, 'DNA repair is limiting for haematopoietic stem cells during ageing', Nature, 447, pp. 686 - 690, http://dx.doi.org/10.1038/nature05875

Liston A; Siggs OM; Goodnow CC, 2007, 'Tracing the action of IL-2 in tolerance to islet-specific antigen', Immunology and Cell Biology, 85, pp. 338 - 342, http://dx.doi.org/10.1038/sj.icb.7100049

Goodnow CC; Campbell JA; Rui L; Vinuesa CG, 2007, 'Tolerance mechanisms in the late phase of the antibody response.', Advances in experimental medicine and biology, 596, pp. 163 - 168

Horikawa K; Martin SW; Pogue SL; Silver K; Peng K; Takatsu K; Goodnow CC, 2007, 'Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors', Journal of Experimental Medicine, 204, pp. 759 - 769, http://dx.doi.org/10.1084/jem.20061923

Li G; Vega R; Nelms K; Gekakis N; Goodnow C; McNamara P; Wu H; Hong NA; Glynne R, 2007, 'A role for Alström syndrome protein, Alms1, in kidney ciliogenesis and cellular quiescence', Plos Genetics, 3, pp. 0009 - 0020, http://dx.doi.org/10.1371/journal.pgen.0030008

Liston A; Hardy K; Pittelkow YE; Wilson SR; Makarof LE; Fahrer AM; Goodnow CC, 2007, 'Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling', Genome Biology, 8, pp. R12 - R12

Kennedy CL; O'Connor AE; Sanchez-Partida LG; Holland MK; Goodnow CC; de Kretser DM; O'Bryan MK, 2006, 'A repository of ENU mutant mouse lines and their potential for male fertility research', Molecular Human Reproduction, 11, pp. 871 - 880, http://dx.doi.org/10.1093/molehr/gah251

Gray DHD; Seach N; Ueno T; Milton MK; Liston A; Lew AM; Goodnow CC; Boyd RL, 2006, 'Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells', Blood, 108, pp. 3777 - 3785, http://dx.doi.org/10.1182/blood-2006-02-004531

Alexander WS; Viney EM; Zhang JG; Metcalf D; Kauppi M; Hyland CD; Carpinelli MR; Stevenson W; Croker BA; Hilton AA; Ellis S; Selan C; Nandurkar HH; Goodnow CC; Kile BT; Nicola NA; Roberts AW; Hilton DJ, 2006, 'Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 16442 - 16447, http://dx.doi.org/10.1073/pnas.0607872103

Manderson AP; Quah B; Botto M; Goodnow CC; Walport MJ; Parish CR, 2006, 'A novel mechanism for complement activation at the surface of B cells following antigen binding', Journal of Immunology, 177, pp. 5155 - 5162, http://dx.doi.org/10.4049/jimmunol.177.8.5155

Rui L; Healy JI; Blasioli J; Goodnow CC, 2006, 'ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation', Journal of Immunology, 177, pp. 5337 - 5346, http://dx.doi.org/10.4049/jimmunol.177.8.5337

Cook MC; Vinuesa CG; Goodnow CC, 2006, 'ENU-mutagenesis: insight into immune function and pathology', Current Opinion in Immunology, 18, pp. 627 - 633, http://dx.doi.org/10.1016/j.coi.2006.07.011

Bléry M; Tze L; Miosge LA; Jun JE; Goodnow CC, 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy', The Journal of Cell Biology, 174, pp. i5 - i5, http://dx.doi.org/10.1083/jcb1742oia5

Bléry M; Tze L; Miosge LA; Jun JE; Goodnow CC, 2006, 'Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-κB in B cell clonal anergy', Journal of Experimental Medicine, 203, pp. 1773 - 1783, http://dx.doi.org/10.1084/jem.20060552

Nijnik A; Ferry H; Lewis G; Rapsomaniki E; Leung JCH; Daser A; Lambe T; Goodnow CC; Cornall RJ, 2006, 'Spontaneous B cell hyperactivity in autoimmune-prone MRL mice', International Immunology, 18, pp. 1127 - 1137, http://dx.doi.org/10.1093/intimm/dxl047

Goodnow CC, 2006, 'Discriminating microbe from self suffers a double toll', Science, 312, pp. 1606 - 1608, http://dx.doi.org/10.1126/science.1129797

Rui L; Goodnow CC, 2006, 'Lymphoma and the control of B cell growth and differentiation', Current Molecular Medicine, 6, pp. 291 - 308, http://dx.doi.org/10.2174/156652406776894563

Arsov T; Larter CZ; Nolan CJ; Petrovsky N; Goodnow CC; Teoh NC; Yeh MM; Farrell GC, 2006, 'Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice', Biochemical and Biophysical Research Communications, 342, pp. 1152 - 1159, http://dx.doi.org/10.1016/j.bbrc.2006.02.032

Hoyne GF; Goodnow CC, 2006, 'The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: Identifying genes that regulate organ-specific and systemic autoimmunity', Immunological Reviews, 210, pp. 27 - 39, http://dx.doi.org/10.1111/j.0105-2896.2006.00363.x

Arsov T; Silva D; O Bryan M; Sainsbury A; Lee NJ; Kennedy C; Manji S; Nelms K; Liu C; Vinuesa C; de Kretser D, 2006, 'Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis', Molecular Endocrinology, 20, pp. 1610 - 1622

Ferry H; Crockford TL; Silver K; Rust N; Goodnow CC; Cornall RJ, 2005, 'Erratum: Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22- independent pathways affecting BCR regulation and B cell survival (European Journal of Immunology (2005) vol. 35 (12) (3714) 10.1002/eji.200535247)', European Journal of Immunology, 35, pp. 3714, http://dx.doi.org/10.1002/eji.255590598

Miosge LA; Goodnow CC, 2005, 'Genes, pathways and checkpoints in lymphocyte development and homeostasis', Immunology and Cell Biology, 83, pp. 318 - 335, http://dx.doi.org/10.1111/j.1440-1711.2005.01353.x

Goodnow CC; Sprent J; Barbara BF; Vinuesa CG, 2005, 'Cellular and genetic mechanisms of self tolerance and autoimmunity', Nature, 435, pp. 590 - 597, http://dx.doi.org/10.1038/nature03724

Vinuesa CG; Cook MC; Angelucci C; Athanasopoulos V; Rui L; Hill KM; Yu D; Domaschenz H; Whittle B; Lambe T; Roberts IS; Copley RR; Bell JI; Cornall RJ; Goodnow CC, 2005, 'A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity', Nature, 435, pp. 452 - 458, http://dx.doi.org/10.1038/nature03555

Liston A; Lesage S; Gray DHD; Boyd RL; Goodnow CC, 2005, 'Genetic lesions in T-cell tolerance and thresholds for autoimmunity', Immunological Reviews, 204, pp. 87 - 101, http://dx.doi.org/10.1111/j.0105-2896.2005.00253.x

Ferry H; Cockford TL; Silver K; Rust N; Goodnow CC; Cornall R, 2005, 'Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival', European Journal of Immunology, 35, pp. 3655 - 3663, http://dx.doi.org/10.1002/eji.200535247

Li G; Vega R; Nelms K; Gekakis N; Goodnow C; McNamara P; Wu H; Hong N; Glynne R, 2005, 'A role for the Alström syndrome protein, Alms1, in ciliogenesis and regulation of cellular quiescence in kidney proximal tubules', PLoS Genetics, preprint, pp. e8 - e8, http://dx.doi.org/10.1371/journal.pgen.0030008.eor

Liston A; Gray DHD; Lesage S; Fletcher AL; Wilson J; Webster KE; Scott HS; Boyd RL; Peltonen L; Goodnow CC, 2004, 'Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity', Journal of Experimental Medicine, 200, pp. 1015 - 1026, http://dx.doi.org/10.1084/jem.20040581

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