By Professor Christopher Carl Goodnow

Journal articles

Cho V; Mei Y; Sanny A; Chan S; Enders A; Bertram EM; Tan A; Goodnow CC; Daniel Andrews T, 2014, 'The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA', Genome Biology, 15, http://dx.doi.org/10.1186/gb-2014-15-1-r26

Daley SR; Coakley KM; Hu DY; Randall KL; Jenne CN; Limnander A; Myers DR; Polakos NK; Enders A; Roots C; Balakishnan B; Miosge LA; Sjollema G; Bertram EM; Field MA; Shao Y; Daniel Andrews T; Whittle B; Whitney Barnes S; Walker JR; Cyster JG; Goodnow CC; Roose JP, 2013, 'Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies', eLife, 2013, http://dx.doi.org/10.7554/eLife.01020

Jamsai D; Clark BJ; Smith SJ; Whittle B; Goodnow CC; Ormandy CJ; O'Bryan MK, 2013, 'A Missense Mutation in the Transcription Factor ETV5 Leads to Sterility, Increased Embryonic and Perinatal Death, Postnatal Growth Restriction, Renal Asymmetry and Polydactyly in the Mouse', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0077311

O'Bryan MK; Clark BJ; McLaughlin EA; D'Sylva RJ; O'Donnell L; Wilce JA; Sutherland J; O'Connor AE; Whittle B; Goodnow CC; Ormandy CJ; Jamsai D, 2013, 'RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility', PLoS Genetics, 9, pp. e1003628, http://dx.doi.org/10.1371/journal.pgen.1003628

Teh CE; Horikawa K; Arnold CN; Beutler B; Kucharska EM; Vinuesa CG; Bertram EM; Goodnow CC; Enders A, 2013, 'Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation', Genes and Immunity, 14, pp. 223 - 233, http://dx.doi.org/10.1038/gene.2013.11

Pratama A; Ramiscal RR; Silva DG; Das SK; Athanasopoulos V; Fitch J; Botelho NK; Chang PP; Hu X; Hogan JJ; Maña P; Bernal D; Korner H; Yu D; Goodnow CC; Cook MC; Vinuesa CG, 2013, 'Roquin-2 shares functions with its paralog roquin-1 in the repression of mrnas controlling t follicular helper cells and systemic inflammation', Immunity, 38, pp. 669 - 680, http://dx.doi.org/10.1016/j.immuni.2013.01.011

Andrews TD; Sjollema G; Goodnow CC, 2013, 'Understanding the immunological impact of the human mutation explosion', Trends in Immunology, 34, pp. 99 - 106, http://dx.doi.org/10.1016/j.it.2012.12.001

Daley SR; Hu DY; Goodnow CC, 2013, 'Helios marks strongly autoreactive CD4⁺ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB', Journal of Experimental Medicine, 210, pp. 269 - 285, http://dx.doi.org/10.1084/jem.20121458

Bergmann H; Yabas M; Short A; Miosge L; Barthel N; Teh CE; Roots CM; Bull KR; Jeelall Y; Horikawa K; Whittle B; Balakishnan B; Sjollema G; Bertram EM; Mackay F; Rimmer AJ; Cornall RJ; Field MA; Andrews TD; Goodnow CC; Enders A, 2013, 'B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8^- dendritic cells require the intramembrane endopeptidase SPPl2A', Journal of Experimental Medicine, 210, pp. 31 - 40, http://dx.doi.org/10.1084/jem.20121076

Crawford G; Enders A; Gileadi U; Stankovic S; Zhang Q; Lambe T; Crockford TL; Lockstone HE; Freeman A; Arkwright PD; Smart JM; Ma CS; Tangye SG; Goodnow CC; Cerundolo V; Godfrey DI; Su HC; Randall KL; Cornall RJ, 2013, 'DOCK8 is critical for the survival and function of NKT cells', Blood, 122, pp. 2052 - 2061, http://dx.doi.org/10.1182/blood-2013-02-482331

Bull KR; Rimmer AJ; Siggs OM; Miosge LA; Roots CM; Enders A; Bertram EM; Crockford TL; Whittle B; Potter PK; Simon MM; Mallon AM; Brown SDM; Beutler B; Goodnow CC; Lunter G; Cornall RJ, 2013, 'Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003219

Enders A; Stankovic S; Teh C; Uldrich AP; Yabas M; Juelich T; Altin JA; Frankenreiter S; Bergmann H; Roots CM; Kyparissoudis K; Goodnow CC; Godfrey DI, 2012, 'ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells', Journal of Immunology, 189, pp. 5240 - 5249, http://dx.doi.org/10.4049/jimmunol.1201486

Jeelall YS; Wang JQ; Law HD; Domaschenz H; Fung HKH; Kallies A; Nutt SL; Goodnow CC; Horikawa K, 2012, 'Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production', Journal of Experimental Medicine, 209, pp. 1907 - 1917, http://dx.doi.org/10.1084/jem.20112744

Altin JA; Goodnow CC; Cook MC, 2012, 'IL-10 ⁺CTLA-4 ⁺ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation', Journal of Immunology, 188, pp. 5478 - 5488, http://dx.doi.org/10.4049/jimmunol.1102994

Andrews TD; Whittle B; Field MA; Balakishnan B; Zhang Y; Shao Y; Cho V; Kirk M; Singh M; Xia Y; Hager J; Winslade S; Sjollema G; Beutler B; Enders A; Goodnow CC, 2012, 'Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: An immediate source for thousands of new mouse models', Open Biology, 2, http://dx.doi.org/10.1098/rsob.120061

O''Donnell L; Rhodes D; Smith SJ; Merriner DJ; Borg C; Whittle B; O'connor A; Smith L; Mcnally FJ; de Kretser D; Goodnow CC; Ormandy CJ, 2012, 'An essential role for katanin p80 and microtubule severing in male gamete production', PLoS Genetics, 8, pp. e1002698, http://dx.doi.org/10.1371/journal.pgen.1002698

Lo JCY; Jamsai D; O'connor A; Borg C; Clark B; Whisstock J; Field M; Adams V; Ishikawa T; Aitken R; Whittle B; Goodnow CC; Ormandy CJ; O'bryan M, 2012, 'RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly', PLoS Genetics, 8, pp. e1002969, http://dx.doi.org/10.1371/journal.pgen.1002969

Yabas M; Godfrey DI; Goodnow CC; Hoyne GF, 2011, 'Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells', PLoS ONE, 6, http://dx.doi.org/10.1371/journal.pone.0026440

Hubert FX; Kinkel SA; Davey GM; Phipson B; Mueller SN; Liston A; Proietto AI; Cannon PZF; Forehan S; Smyth GK; Wu L; Goodnow CC; Carbone FR; Scott HS; Heath WR, 2011, 'Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance', Blood, 118, pp. 2462 - 2472, http://dx.doi.org/10.1182/blood-2010-06-286393

Tian L; Altin JA; Makaroff LE; Franckaert D; Cook MC; Goodnow CC; Dooley J; Liston A, 2011, 'Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis', Blood, 118, pp. 1845 - 1853, http://dx.doi.org/10.1182/blood-2011-04-346056

Silva DG; Daley SR; Hogan J; Lee SK; Teh CE; Hu DY; Lam KP; Goodnow CC; Vinuesa CG, 2011, 'Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells', Diabetes, 60, pp. 2102 - 2111, http://dx.doi.org/10.2337/db10-1344

Hoyne GF; Flening E; Yabas M; Teh C; Altin JA; Randall K; Thien CBF; Langdon WY; Goodnow CC, 2011, 'Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes', Journal of Immunology, 186, pp. 2024 - 2032, http://dx.doi.org/10.4049/jimmunol.1002296

Beutler B; Goodnow CC, 2011, 'How host defense is encoded in the mammalian genome', Mammalian Genome, 22, pp. 1 - 5, http://dx.doi.org/10.1007/s00335-010-9312-4

Tze LE; Horikawa K; Domaschenz H; Howard DR; Roots CM; Rigby RJ; Way DA; Ohmura-Hoshino M; Ishido S; Andoniou CE; Degli-Esposti MA; Goodnow CC, 2011, 'CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10 - Driven MARCH1-mediated ubiquitination and degradation', Journal of Experimental Medicine, 208, pp. 149 - 165, http://dx.doi.org/10.1084/jem.20092203

Altin JA; Tian L; Liston A; Bertram EM; Goodnow CC; Cook MC, 2011, 'Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus TH2 effector cells to cause allergy', Journal of Allergy and Clinical Immunology, 127, pp. 1277 - 1285.e5, http://dx.doi.org/10.1016/j.jaci.2010.12.1081

Yabas M; Teh C; Frankenreiter S; Lal D; Roots CM; Whittle B; Andrews DT; Zhang Y; Teoh NC; Sprent J; Tze LE; Kucharska E; Kofler J; Farell GC; Broer S; Goodnow CC; Enders A, 2011, 'ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes', Nature Immunology, 12, pp. 441 - 452, http://dx.doi.org/10.1038/ni.2011

Sontani ; Chapman G; Papathanasiou P; Dunwoodie SL; Goodnow CC; Hoyne GF, 2011, 'Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL', Leukemia Research, 35, pp. 1512 - 1519, http://dx.doi.org/10.1016/j.leukres.2011.07.024

Randall KL; Chang SS; Ma CS; Fung I; Mei Y; Yabas M; Tan A; Arkwright PD; Suwairi WA; Reyes S; Yamazaki-Nakashimada MA; Garcia-Cruz D; Smart J; Picard C; Okada S; Jouanguy E; Casanova J-L; Lambert T; Cornall RJ; Russell S; Oliaro J; Tangye SG; Bertram EM; Goodnow CC, 2011, 'DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice', Journal of Experimental Medicine, 208, pp. 2305 - 2320, http://dx.doi.org/10.1084/jem.20110345

Xia Y; Won S; Du X; Lin P; Ross C; La Vine D; Wiltshire S; Leiva G; Vidal SM; Whittle B; Goodnow CC; Koziol J; Moresco EMY; Beutler B, 2010, 'Bulk segregation mapping of mutations in closely related strains of mice', Genetics, 186, pp. 1139 - 1145, http://dx.doi.org/10.1534/genetics.110.121160

Vinuesa CG; Linterman MA; Goodnow CC; Randall KL, 2010, 'T cells and follicular dendritic cells in germinal center B-cell formation and selection', Immunological Reviews, 237, pp. 72 - 89, http://dx.doi.org/10.1111/j.1600-065X.2010.00937.x

Teh CE; Daley SR; Enders A; Goodnow CC, 2010, 'T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 14709 - 14714, http://dx.doi.org/10.1073/pnas.1009209107

Wu Z; Yates AL; Hoyne GF; Goodnow CC, 2010, 'Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation', Journal of Immunology, 185, pp. 231 - 238, http://dx.doi.org/10.4049/jimmunol.0903625

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; MacKay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa CG; Batista FD; Cornall RJ; Goodnow CC, 2010, 'Erratum: Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production (Nature Immunology (2009) 10 (1283-1291))', Nature Immunology, 11, pp. 644, http://dx.doi.org/10.1038/ni0710-644a

Athanasopoulos V; Barker A; Yu D; Tan AHM; Srivastava M; Contreras N; Wang J; Lam KP; Brown SHJ; Goodnow CC; Dixon NE; Leedman PJ; Saint R; Vinuesa CG, 2010, 'The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs', FEBS Journal, 277, pp. 2109 - 2127, http://dx.doi.org/10.1111/j.1742-4658.2010.07628.x

Zikherman J; Jenne C; Watson S; Doan K; Raschke W; Goodnow CC; Weiss A, 2010, 'CD45-Csk Phosphatase-Kinase Titration Uncouples Basal and Inducible T Cell Receptor Signaling during Thymic Development', Immunity, 32, pp. 342 - 354, http://dx.doi.org/10.1016/j.immuni.2010.03.006

Johnson AL; Aravind L; Shulzhenko N; Morgun A; Choi SY; Crockford TL; Lambe T; Domaschenz H; Kucharska EM; Zheng L; Vinuesa CG; Lenardo MJ; Goodnow CC; Cornall RJ; Schwartz RH, 2010, 'Erratum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection (Nature Immunology (2009) 10 (831-839))', Nature Immunology, 11, pp. 97, http://dx.doi.org/10.1038/ni0110-97a

Theodoratos A; Whittle B; Enders A; Tscharke DC; Roots CM; Goodnow CC; Fahrer AM, 2010, 'Mouse strains with point mutations in TAP1 and TAP2', Immunology and Cell Biology, 88, pp. 72 - 78, http://dx.doi.org/10.1038/icb.2009.61

Randall KL; Lambe T; Goodnow CC; Cornall RJ, 2010, 'The essential role of DOCK8 in humoral immunity', Disease Markers, 29, pp. 141 - 150, http://dx.doi.org/10.3233/DMA-2010-0739

Goodnow CC; Vinuesa C; Randall KL; Mackay F; Brink R, 2010, 'Control systems and decision making for antibody production', Nature Immunology, 11, pp. 681 - 688, http://dx.doi.org/10.1038/ni.1900

Simpson N; Gatenby P; Wilson A; Malik S; Fulcher DA; Tangye SG; Manku H; Vyse TJ; Roncador G; Huttley G; Goodnow CC; Vinuesa C; Cook MC, 2010, 'Expansion of circulating T cells resembling follicular T helper cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus', Arthritis Care & Research, 62, pp. 234 - 244

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice (Reprinted from Nature, vol 334, pg 676-682, 1988)', JOURNAL OF IMMUNOLOGY, 183, pp. 5442 - 5448, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271488500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Goodnow CC; Crosbie J; Adelstein S; Lavoie TB; Smith-Gill SJ; Brink RA; Pritchard-Briscoe H; Wotherspoon JS; Loblay RH; Raphael K; Trent RJ; Basten A, 2009, 'Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.', Journal of immunology (Baltimore, Md. : 1950), 183, pp. 5442 - 5448

Jenne CN; Enders A; Rivera R; Watson SR; Bankovich AJ; Pereira JP; Xu Y; Roots CM; Beilke JN; Banerjee A; Reiner SL; Miller SA; Weinmann AS; Goodnow CC; Lanier LL; Cyster JG; Chun J, 2009, 'T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow', Journal of Experimental Medicine, 206, pp. 2469 - 2481, http://dx.doi.org/10.1084/jem.20090525

Johnson AL; Aravind L; Shulzhenko N; Morgun A; Choi SY; Crockford TL; Lambe T; Domaschenz H; Kucharska EM; Zheng L; Vinuesa CG; Lenardo MJ; Goodnow CC; Cornall RJ; Schwartz RH, 2009, 'Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection', Nature Immunology, 10, pp. 831 - 839, http://dx.doi.org/10.1038/ni.1769

Nijnik A; Dawson S; Crockford TL; Woodbine L; Visetnoi S; Bennett S; Jones M; Turner GD; Jeggo PA; Goodnow CC; Cornall RJ, 2009, 'Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome', Journal of Clinical Investigation, 119, pp. 1696 - 1705, http://dx.doi.org/10.1172/JCI32743

Lambe T; Simpson RJ; Dawson S; Bouriez-Jones T; Crockford TL; Lepherd M; Latunde-Dada GO; Robinson H; Raja KB; Campagna DR; Villarreal G; Ellory JC; Goodnow CC; Fleming MD; McKie AT; Cornall RJ, 2009, 'Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism', Blood, 113, pp. 1805 - 1808, http://dx.doi.org/10.1182/blood-2007-11-120402

Chu J; Hong NA; Masuda CA; Jenkins BV; Nelms KA; Goodnow CC; Glynne RJ; Wu H; Masliah E; Joazeiro CAP; Kay SA, 2009, 'A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 2097 - 2103, http://dx.doi.org/10.1073/pnas.0812819106

Randall KL; Lambe T; Johnson A; Treanor B; Kucharska E; Domaschenz H; Whittle B; Tze LE; Enders A; Crockford TL; Bouriez-Jones T; Alston D; Cyster JG; Lenardo MJ; Mackay F; Deenick EK; Tangye SG; Chan TD; Camidge T; Brink R; Vinuesa C; Batista FD; Cornall RJ; Goodnow CC, 2009, 'Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production', Nature Immunology, 10, pp. 1283 - 1291, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19898472

Linterman MA; Rigby RJ; Wong R; Silva D; Withers D; Anderson G; Verma NK; Brink R; Hutloff A; Goodnow CC; Vinuesa C, 2009, 'Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS', Immunity, 30, pp. 228 - 241, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19217324

Wu Z; Jia X; de la Cruz L; Su XC; Marzolf B; Troisch P; Zak D; Hamilton A; Whittle B; Yu D; Sheahan D; Bertram E; Aderem A; Otting G; Goodnow CC; Hoyne GF, 2008, 'Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL', Immunity, 29, pp. 863 - 875, http://dx.doi.org/10.1016/j.immuni.2008.11.004

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