By Professor Christopher Carl Goodnow

Journal articles

Singh M; Jackson KJL; Wang JJ; Schofield P; Field MA; Koppstein D; Peters TJ; Burnett DL; Rizzetto S; Nevoltris D; Masle-Farquhar E; Faulks ML; Russell A; Gokal D; Hanioka A; Horikawa K; Colella AD; Chataway TK; Blackburn J; Mercer TR; Langley DB; Goodall DM; Jefferis R; Gangadharan Komala M; Kelleher AD; Suan D; Rischmueller M; Christ D; Brink R; Luciani F; Gordon TP; Goodnow CC; Reed JH, 2020, 'Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody', Cell, 180, pp. 878 - 894.e19, http://dx.doi.org/10.1016/j.cell.2020.01.029

Lau A; Avery DT; Jackson K; Lenthall H; Volpi S; Brigden H; Russell AJ; Bier J; Reed JH; Smart JM; Cole T; Choo S; Gray PE; Berglund LJ; Hsu P; Wong M; O'Sullivan M; Boztug K; Meyts I; Uzel G; Notarangelo LD; Brink R; Goodnow CC; Tangye SG; Deenick EK, 2020, 'Activated PI3Kd breaches multiple B cell tolerance checkpoints and causes autoantibody production', Journal of Experimental Medicine, 217, http://dx.doi.org/10.1084/jem_20191336

Stirzaker C; Skvortsova K; Masle-Farquhar E; Goodnow C; Clark SJ, 2020, 'Epigenetic changes during tumour development – Functional epigenetics study', Pathology, 52, pp. S29 - S29, http://dx.doi.org/10.1016/j.pathol.2020.01.121

Rouet R; Mazigi O; Walker G; Langley D; Sobti M; Schofield P; Lenthall H; Jackson J; Ubiparipovic S; Henry J; Abayasingam A; Burnett D; Kelleher A; Brink R; Bull R; Turville S; Stewart A; Goodnow C; Rawlinson W; Christ D, 2020, 'Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies', , http://dx.doi.org/10.1101/2020.12.14.422791

Wirasinha RC; Chan A; Yap JY; Hu DY; Teh CE; Gray DHD; Goodnow CC; Daley SR, 2019, 'Deletion of self-reactive CCR7– thymocytes in the absence of MHC expression on thymic epithelial cells', Cell Death and Differentiation, 26, pp. 2727 - 2739, http://dx.doi.org/10.1038/s41418-019-0331-8

Singh M; Al-Eryani G; Carswell S; Ferguson JM; Blackburn J; Barton K; Roden D; Luciani F; Giang Phan T; Junankar S; Jackson K; Goodnow CC; Smith MA; Swarbrick A, 2019, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11049-4

Burnett DL; Reed JH; Christ D; Goodnow CC, 2019, 'Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity', Immunological Reviews, 292, pp. 61 - 75, http://dx.doi.org/10.1111/imr.12808

Zammit NW; Siggs OM; Gray PE; Horikawa K; Langley DB; Walters SN; Daley SR; Loetsch C; Warren J; Yap JY; Cultrone D; Russell A; Malle EK; Villanueva JE; Cowley MJ; Gayevskiy V; Dinger ME; Brink R; Zahra D; Chaudhri G; Karupiah G; Whittle B; Roots C; Bertram E; Yamada M; Jeelall Y; Enders A; Clifton BE; Mabbitt PD; Jackson CJ; Watson SR; Jenne CN; Lanier LL; Wiltshire T; Spitzer MH; Nolan GP; Schmitz F; Aderem A; Porebski BT; Buckle AM; Abbott DW; Ziegler JB; Craig ME; Benitez-Aguirre P; Teo J; Tangye SG; King C; Wong M; Cox MP; Phung W; Tang J; Sandoval W; Wertz IE; Christ D; Goodnow CC; Grey ST, 2019, 'Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity', Nature Immunology, 20, pp. 1299 - 1310, http://dx.doi.org/10.1038/s41590-019-0492-0

Policheni A; Horikawa K; Milla L; Kofler J; Bouillet P; Belz GT; O'Reilly LA; Goodnow CC; Strasser A; Gray DHD, 2019, 'CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3⁺ regulatory T cells', Immunology and Cell Biology, 97, pp. 740 - 752, http://dx.doi.org/10.1111/imcb.12268

Siggs OM; Russell A; Singh-Grewal D; Wong M; Chan P; Craig ME; O'Loughlin T; Stormon M; Goodnow CC, 2019, 'Preponderance of CTLA4 Variation Associated With Autosomal Dominant Immune Dysregulation in the MYPPPY Motif', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.01544

Moran I; Avery DT; Payne K; Lenthall H; Davies EG; Burns S; Ip W; Oleastro MM; Reisli I; Guner S; Keles S; Notarangelo L; Deenick EK; Goodnow CC; Zahra D; Brink R; Wong M; Tangye SG; Ma CS; Phan TG, 2019, 'B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects', Journal of Allergy and Clinical Immunology, 143, pp. 2302 - 2305, http://dx.doi.org/10.1016/j.jaci.2019.02.010

Kayagaki N; Lee BL; Stowe IB; Kornfeld OS; O'Rourke K; Mirrashidi KM; Haley B; Watanabe C; Roose-Girma M; Modrusan Z; Kummerfeld S; Reja R; Zhang Y; Cho V; Daniel Andrews T; Morris LX; Goodnow CC; Bertram EM; Dixit VM, 2019, 'IRF2 transcriptionally induces GSDMD expression for pyroptosis', Science Signaling, 12, http://dx.doi.org/10.1126/scisignal.aax4917

Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004

Koay HF; Su S; Amann-Zalcenstein D; Daley SR; Comerford I; Miosge L; Whyte CE; Konstantinov IE; D'Udekem Y; Baldwin T; Hickey PF; Berzins SP; Mak JYW; Sontani Y; Roots CM; Sidwell T; Kallies A; Chen Z; Nüssing S; Kedzierska K; Mackay LK; McColl SR; Deenick EK; Fairlie DP; McCluskey J; Goodnow CC; Ritchie ME; Belz GT; Naik SH; Pellicci DG; Godfrey DI, 2019, 'A divergent transcriptional landscape underpins the development and functional branching of MAIT cells', Science Immunology, 4, http://dx.doi.org/10.1126/sciimmunol.aay6039

Zammit N; Siggs OM; Gray P; King C; Christ D; Goodnow CC; Grey S; Cowley M; Craig M; Dinger M; Ziegler J; Villanueva J; Cultrone D; Brink R, 2019, 'Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants', bioRxiv, pp. 589507, http://dx.doi.org/10.1101/589507

Jeelall Y; Singh M; Lai J; Ali S; Jackson K; Hollingsworth P; De Boer B; Wood B; Reed J; Goodnow C; Mclean-Tooke A; Lucas M, 2019, 'Oligoclonal lymphocytosis and cytokine derangement in a case of severe adverse drug reaction', Pathology, 51, pp. S131 - S131, http://dx.doi.org/10.1016/j.pathol.2018.12.378

Barnet M; Pathmanandavel S; McCarthy L; Goodnow C; Joshua A, 2019, 'The Australian Exceptional Responders Program: A national collaboration', Annals of Oncology, 30, pp. v794 - v795, http://dx.doi.org/10.1093/annonc/mdz268.104

Alshekaili J; Chand R; Lee CE; Corley S; Kwong K; Papa I; Fulcher DA; Randall KL; Leiding JW; Ma CS; Wilkins MR; Uzel G; Goodnow CC; Vinuesa CG; Tangye SG; Cook MC, 2018, 'STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles', Scientific Reports, 8, pp. 3529, http://dx.doi.org/10.1038/s41598-018-21389-8

Wang JJ; Reed JH; Colella AD; Russell AJ; Murray-Brown W; Chataway TK; Jackson KJL; Goodnow CC; Gordon TP, 2018, 'Molecular Profiling and Clonal Tracking of Secreted Rheumatoid Factors in Primary Sjögren's Syndrome', Arthritis and Rheumatology, 70, pp. 1617 - 1625, http://dx.doi.org/10.1002/art.40539

Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed JH; Cai CH; Lloyd AR; Eltahla AA; Goodnow CC; Luciani F, 2018, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', Bioinformatics, 34, pp. 2846 - 2847, http://dx.doi.org/10.1093/BIOINFORMATICS/BTY171

Barnet MB; Blinman P; Cooper W; Boyer MJ; Kao S; Goodnow CC, 2018, 'Understanding Immune Tolerance of Cancer: Re-Purposing Insights from Fetal Allografts and Microbes', BioEssays, 40, http://dx.doi.org/10.1002/bies.201800050

Wagle MV; Marchingo JM; Howitt J; Tan SS; Goodnow CC; Parish IA, 2018, 'The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8⁺ T Cell Tolerance Checkpoint to High-Dose Antigen', Cell Reports, 24, pp. 577 - 584, http://dx.doi.org/10.1016/j.celrep.2018.06.060

Yap JY; Wirasinha RC; Chan A; Howard DR; Goodnow CC; Daley SR, 2018, 'Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes', Immunology, 154, pp. 522 - 532, http://dx.doi.org/10.1111/imm.12904

Wirasinha RC; Singh M; Archer SK; Chan A; Harrison PF; Goodnow CC; Daley SR, 2018, 'αβ T-cell receptors with a central CDR3 cysteine are enriched in CD8αα intraepithelial lymphocytes and their thymic precursors', Immunology and Cell Biology, 96, pp. 553 - 561, http://dx.doi.org/10.1111/imcb.12047

Burnett DL; Langley DB; Schofield P; Hermes JR; Chan TD; Jackson J; Bourne K; Reed JH; Patterson K; Porebski BT; Brink R; Christ D; Goodnow CC, 2018, 'Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination', Science, 360, pp. 223 - 226, http://dx.doi.org/10.1126/science.aao3859

Singh M; Al-Eryani G; Carswell S; Ferguson J; Blackburn J; Barton K; Roden D; Luciani F; Phan T; Junankar S; Jackson K; Goodnow C; Smith M; Swarbrick A, 2018, 'High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes', , http://dx.doi.org/10.1101/424945

Oakes SR; Gallego-Ortega D; Stanford PM; Junankar S; Au WWY; Kikhtyak Z; von Korff A; Sergio CM; Law AMK; Castillo LE; Allerdice SL; Young AIJ; Piggin C; Whittle B; Bertram E; Naylor MJ; Roden DL; Donovan J; Korennykh A; Goodnow CC; O’Bryan MK; Ormandy CJ, 2017, 'A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation', PLoS Genetics, 13, pp. e1007072, http://dx.doi.org/10.1371/journal.pgen.1007072

Langley DB; Crossett B; Schofield P; Jackson J; Zeraati M; Maltby D; Christie M; Burnett D; Brink R; Goodnow C; Christ D, 2017, 'Structural basis of antigen recognition: Crystal structure of duck egg lysozyme', Acta Crystallographica Section D: Structural Biology, 73, pp. 910 - 920, http://dx.doi.org/10.1107/S2059798317013730

Burnett DL; Parish IA; Masle-Farquhar E; Brink R; Goodnow CC, 2017, 'Murine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation', Immunology and Cell Biology, 95, pp. 775 - 788, http://dx.doi.org/10.1038/icb.2017.50

Miosge LA; Sontani Y; Chuah A; Horikawa K; Russell TA; Meia Y; Wagle MV; Howard DR; Enders A; Tscharke DC; Goodnow CC; Parish IA, 2017, 'Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. E5216 - E5225, http://dx.doi.org/10.1073/pnas.1705795114

Isaacs M; Tonks KT; Greenfield JR, 2017, 'Euglycaemic diabetic ketoacidosis in patients using sodium-glucose co-transporter 2 inhibitors', Internal Medicine Journal, 47, pp. 701 - 704, http://dx.doi.org/10.1111/imj.13442

Hu DY; Wirasinha RC; Goodnow CC; Daley SR, 2017, 'IL-2 prevents deletion of developing T-regulatory cells in the thymus', Cell Death and Differentiation, 24, pp. 1007 - 1016, http://dx.doi.org/10.1038/cdd.2017.38

Tangye SG; Pillay B; Randall KL; Avery DT; Tri GP; Gray P; Ziegler JB; Smart JM; Peake J; Arkwright PD; Hambleton S; Orange J; Goodnow CC; Uzel G; Casanova J-L; Lugo Reyes SO; Freeman AF; Su HC; Ma CS, 2017, 'Dedicator of cytokinesis 8-deficient CD4(+) T cells are biased to a T(H)2 effector fate at the expense of T(H)1 and T(H)17 cells', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 139, pp. 933 - 949, http://dx.doi.org/10.1016/j.jaci.2016.07.016

Tangye SG; Pillay B; Randall KL; Avery DT; Phan TG; Gray P; Ziegler JB; Smart JM; Peake J; Arkwright PD; Hambleton S; Orange J; Goodnow CC; Uzel G; Casanova JL; Lugo Reyes SO; Freeman AF; Su HC; Ma CS, 2017, 'Dedicator of cytokinesis 8–deficient CD4⁺ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells', Journal of Allergy and Clinical Immunology, 139, pp. 933 - 949, http://dx.doi.org/10.1016/j.jaci.2016.07.016

Petersons CJ; Mangelsdorf BL; Poljak A; Smith MD; Greenfield JR; Thompson CH; Burt MG, 2017, 'Low dose prednisolone and insulin sensitivity differentially affect arterial stiffness and endothelial function: An open interventional and cross-sectional study', Atherosclerosis, 258, pp. 34 - 39, http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.033

Chen DLT; Brown R; Liess C; Poljak A; Xu A; Zhang J; Trenell M; Jenkins A; Chisholm D; Samocha-Bonet D; Macefield VG; Greenfield JR; Chen D; Milliken S; Goodnow C, 2017, 'Muscle sympathetic nerve activity is associated with liver insulin sensitivity in obese non-diabetic men', Frontiers in Physiology, 8, pp. 101, http://dx.doi.org/10.3389/fphys.2017.00101

Wang JQ; Jeelall YS; Humburg P; Batchelor EL; Kaya SM; Yoo HM; Goodnow CC; Horikawa K, 2017, 'Synergistic cooperation and crosstalk between MYD88^L265P and mutations that dysregulate CD79B and surface IgM', Journal of Experimental Medicine, 214, pp. 2759 - 2776, http://dx.doi.org/10.1084/jem.20161454

McNamara HA; Cai Y; Wagle MV; Sontani Y; Roots CM; Miosge LA; O’Connor JH; Sutton HJ; Ganusov VV; Heath WR; Bertolino P; Goodnow CG; Parish IA; Enders A; Cockburn IA, 2017, 'Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids', Science Immunology, 2, http://dx.doi.org/10.1126/sciimmunol.aaj1996

Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed J; Cai C; Lloyd A; Eltahla A; Goodnow C; Luciani F, 2017, 'B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle', , http://dx.doi.org/10.1101/181156

Smith FC; Kumar SS; Furlong TJ; Gangaram SV; Greenfield JR; Stocker SL; Graham GG; Williams KM; Day RO, 2016, 'Pharmacokinetics of Metformin in Patients Receiving Regular Hemodiafiltration', American Journal of Kidney Diseases, 68, pp. 990 - 992, http://dx.doi.org/10.1053/j.ajkd.2016.08.017

Moon J; Kumar SS; Graham GG; Baysari MT; Williams KM; Chen W; Viardot A; Greenfield JR; Day RO, 2016, 'Trends in metformin utilisation and dose appropriateness in Australia', European Journal of Clinical Pharmacology, 72, pp. 1489 - 1496, http://dx.doi.org/10.1007/s00228-016-2117-y

Cho JH; Kim HO; Ju YJ; Kye YC; Lee GW; Lee SW; Yun CH; Bottini N; Webster K; Goodnow CC; Surh CD; King C; Sprent J, 2016, 'CD45-mediated control of TCR tuning in naïve and memory CD8⁺ T cells', Nature Communications, 7, pp. 13373, http://dx.doi.org/10.1038/ncomms13373

Sabouri Z; Perotti S; Spierings E; Humburg P; Yabas M; Bergmann H; Horikawa K; Roots C; Lambe S; Young C; Andrews TD; Field M; Enders A; Reed JH; Goodnow CC, 2016, 'IgD attenuates the IgM-induced anergy response in transitional and mature B cells', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms13381

Bishay RH; Greenfield JR, 2016, 'A review of maturity onset diabetes of the young (MODY) and challenges in the management of glucokinase-MODY', Medical Journal of Australia, 205, pp. 480 - 485, http://dx.doi.org/10.5694/MJA16.00458

He J; Chen DL; Samocha-Bonet D; Gillinder KR; Barclay JL; Magor GW; Perkins AC; Greenfield JR; Yang G; Whitehead JP, 2016, 'Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4)–a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity', Growth Factors, 34, pp. 210 - 216, http://dx.doi.org/10.1080/08977194.2017.1285764

Lee-Young RS; Hoffman NJ; Murphy KT; Henstridge DC; Samocha-Bonet D; Siebel AL; Iliades P; Zivanovic B; Hong YH; Colgan TD; Kraakman MJ; Bruce CR; Gregorevic P; McConell GK; Lynch GS; Drummond GR; Kingwell BA; Greenfield JR; Febbraio MA; Milliken S; Goodnow C, 2016, 'Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle', Molecular Metabolism, 5, pp. 1083 - 1091, http://dx.doi.org/10.1016/j.molmet.2016.09.002

Koay HF; Gherardin NA; Enders A; Loh L; Mackay LK; Almeida CF; Russ BE; Nold-Petry CA; Nold MF; Bedoui S; Chen Z; Corbett AJ; Eckle SBG; Meehan B; D'Udekem Y; Konstantinov IE; Lappas M; Liu L; Goodnow CC; Fairlie DP; Rossjohn J; Chong MM; Kedzierska K; Berzins SP; Belz GT; McCluskey J; Uldrich AP; Godfrey DI; Pellicci DG, 2016, 'A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage', Nature Immunology, 17, pp. 1300 - 1311, http://dx.doi.org/10.1038/ni.3565

Janssen E; Tohme M; Hedayat M; Leick M; Kumari S; Ramesh N; Massaad MJ; Ullas S; Azcutia V; Goodnow CC; Randall KL; Qiao Q; Wu H; Al-Herz W; Cox D; Hartwig J; Irvine DJ; Luscinskas FW; Geha RS, 2016, 'A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton', Journal of Clinical Investigation, 126, pp. 3837 - 3851, http://dx.doi.org/10.1172/JCI85774

Parish IA; Stamp LA; Lorenzo AMD; Fowler SM; Sontani Y; Miosge LA; Howard DR; Goodnow CC; Young HM; Furness JB, 2016, 'A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy', American Journal of Pathology, 186, pp. 2254 - 2261, http://dx.doi.org/10.1016/j.ajpath.2016.04.016

Hillhouse EE; Liston A; Collin R; Desautels E; Goodnow CC; Lesage S, 2016, 'TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints', Immunology and Cell Biology, 94, pp. 709 - 713, http://dx.doi.org/10.1038/icb.2016.27

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